Disease relevance of Sensation Disorders

• Eight of them (34.8%) had kidney disorders (low creatinine clearance, fluctuating microproteinuria, echographic changes), and nine children (39.1%) had peripheral neuropathy (sensory disorders as assessed by electromyography) [1].

High impact information on Sensation Disorders

• Is dystonia a sensory disorder [2]?
• Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders [3].
• Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor [4].
• Thus, intravenous lidocaine is proposed as a diagnostic aid in the examination of patients complaining of complex sensory disorders associated with nerve injury [5].
• In the present study, we investigated the effects of an EP1 antagonist on these sensory disorders by use of ONO-NT-012 or AH6809 [6].

Chemical compound and disease context of Sensation Disorders

• We investigated whether sensory disorders in rats were related to glucose metabolism by aldose reductase [4].
• We characterized prostaglandin E receptor subtypes (EP1-3) involved in these sensory disorders by use of 7 synthetic prostanoid analogues [7].
• The possible mechanisms responsible for the conversion of the high threshold phasic flexor reflex into a low threshold tonic reflex are discussed as are the possible implications for sensory disorders that accompany chronic injury in man [8].
• Based on this observation we attempted to develop an hypothesis of the possible role vitamin E might play in these sensory disorders [9].
• This suggests, by inference, a crucial contribution of the NMDA-induced increased excitability to the expression of neuronal sensitization related to this painful sensory disorder [10].

Gene context of Sensation Disorders

• RHDP performed defectively whether they had closed or open eyes, which tends to indicate a perceptual multimodal integration disorder rather than a modality-related sensory disorder [11].

References