Disease relevance of Tuberculosis, Spinal

• Mycobacterium tuberculosis chaperonin 10 stimulates bone resorption: a potential contributory factor in Pott's disease [1].
• A case of recurrent Mycobacterium xenopi infection presenting as Pott's disease in a patient receiving etanercept for severe rheumatoid arthritis is described [2].
• Tc-99m tetrofosmin uptake in pulmonary tuberculosis with Pott's disease [3].
• The incidence was high in patients treated with daily regimens of isoniazid and rifampicin: 16-39% in children with tuberculous meningitis, 10% in patients with spinal tuberculosis (non-surgical cases), and 2-8% in those with pulmonary tuberculosis [4].
• Sequelae observed during the follow up were; motor-mental retardation in 3 cases, hemiparesis in 2 cases, strabismus in one case with CNS TB and vertebral deformation in 2 cases with Pott's disease [5].

High impact information on Tuberculosis, Spinal

• Spinal tuberculosis: remember streptomycin [6].
• Late reactivation of spinal tuberculosis by low-dose methotrexate therapy in a patient with rheumatoid arthritis [7].
• In contrast, six patients who had spinal tuberculosis had a mean CD4 count of 75.7 cells/mm(3) (p = 0.005), and one of them died during the hospitalization [8].
• We retrospectively reviewed 12 patients with spinal tuberculosis of the thoracic and lumbar spine who had radical débridement, anterior decompression, interbody arthrodesis with an anterior interbody titanium cage, and autologous bone grafts, combined with a standardized perioperative antituberculous regimen [9].
• With clinical findings, histopathology, polymerase chain reaction, PA lung graph, and computerised tomography, the patient was diagnosed with metastatic tuberculosis abscess associated with lung tuberculosis and Pott's disease [10].

Chemical compound and disease context of Tuberculosis, Spinal

• The authors describe Pott's disease incidentally detected on Tc-99m MDP bone and Ga-67 imaging in a patient with diabetes [11].
• MATERIALS AND METHODS: The records of 61 consecutive patients, of surgically treated spinal tuberculosis affecting C3 to D2 region, in our neuro and spinal surgery unit over a five-year period were retrospectively reviewed [12].

Gene context of Tuberculosis, Spinal

• Patients with a more severely decreased CD4 count (50 to 200 cells/mm(3)) may have spinal tuberculosis develop, and patients with the lowest CD4 counts are more likely to have epidural abscesses develop [8].
• The authors experience with 10 consecutive patients (six women, four men) who underwent video-assisted thoracoscopic surgery for the treatment of spinal tuberculosis involving levels from T5 to T11, from January 1996 to December 1997, was analyzed [13].

References