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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Debridement


High impact information on Debridement

  • INTERVENTION: Initial debridement and 2-week intravenous course of flucloxacillin or vancomycin with rifampin or placebo, followed by either ciprofloxacin-rifampin or ciprofloxacin-placebo long-term therapy [6].
  • Although the tensile properties of the wounds were unchanged, ultrastructural analysis showed a significantly decreased level of debridement, greater disorganization of matrix, and an alteration of collagen fibrillogenesis leading to small diameter collagen fibrils in the OPN mutant mice [7].
  • Although little studied in vivo, elastin repair is thought to occur through a sequential process involving enzymatic removal (debridement) of damaged fibers followed by synthesis of tropoelastin, its subsequent processing, and eventual incorporation into new insoluble elastin [8].
  • Amphotericin B with surgical debridement of the affected joint was successful treatment in four patients [9].
  • Activin A expression increased steadily from day 2 until day 8 after mechanical debridement in vivo, paralleling vascular endothelial growth factor (VEGF) expression [10].

Chemical compound and disease context of Debridement


Biological context of Debridement


Anatomical context of Debridement


Associations of Debridement with chemical compounds

  • Human burn tissues (n = 44) representing days 2 to 12 after injury were obtained during surgical debridement, fixed in 4% paraformaldehyde, and embedded in paraffin [26].
  • Management of individual cases should include surgical débridement combined with high-dose parenteral penicillin, followed by long-term penicillin therapy, orally [27].
  • Therapy, consisting of aggressive surgical debridement, intravenous amphotericin B, and oral flucytosine was unsuccessful in eradicating the organism [28].
  • Cure was achieved by debridement and chemotherapy with ethambutol and rifampin [29].
  • The authors analyzed 27 patients with pancreatic abscess treated since 1975 at hospitals affiliated with the University of Louisville School of Medicine. Treatment consisted of careful debridement, abscess drainage, and multiple antibiotics in all patients [30].

Gene context of Debridement

  • CONCLUSIONS: Corneal epithelial debridement causes a transient upregulation of Shh expression and activation of Shh/Gli-3 signaling cascade in healing corneal and limbal epithelia [31].
  • These lesions either did not resolve and required surgical debridement (5 patients) or resolved slowly with conservative management that included discontinuation of IFN at the specific, involved site [32].
  • METHODS: In 43 consecutive patients with knee OA undergoing arthroscopic debridement, we examined the amount of MMP-2 and MMP-9 in a series of chondral, meniscal, and synovial cultures [33].
  • To explore the cells and components involved in plasminogen activation, we have performed a combined immunohistological and zymographic study on human skin wounds produced iatrogenically by debridement [34].
  • However, in the debridement model, Smad 2 localization remained primarily cytoplasmic [35].

Analytical, diagnostic and therapeutic context of Debridement

  • Judicious use of immunosuppressive agents, a high index of suspicion, early diagnosis, and combination treatment with amphotericin B and surgical debridement may improve the prognosis of this serious infection [36].
  • Delayed debridement and thrombectomy plus vena cava repair with suturing of liver lacerations in these patients obviated heroic efforts at primary repair [37].
  • Parenteral antibiotics are used as an adjunct to amputation or operative debridement for patients with diabetes who require emergency surgery for a septic foot [38].
  • We have studied the disposition of alfentanil in six patients (who had suffered 10-30% surface area burns 5-21 days previously) undergoing surgical debridement and grafting and compared the data with those from a control group of six patients matched for age, sex and weight undergoing body surface surgery of similar duration [39].
  • The lesion was successfully treated with debridement, local wound care, parenteral administration of amphotericin B, and ultimately by surgical excision and split-thickness skin grafting [40].


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  2. Septic necrosis of the midline wound in postoperative peritonitis. Successful management by debridement, myocutaneous advancement, and primary skin closure. Lévy, E., Palmer, D.L., Frileux, P., Hannoun, L., Nordlinger, B., Tiret, E., Honiger, J., Parc, R. Ann. Surg. (1988) [Pubmed]
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  7. Altered wound healing in mice lacking a functional osteopontin gene (spp1). Liaw, L., Birk, D.E., Ballas, C.B., Whitsitt, J.S., Davidson, J.M., Hogan, B.L. J. Clin. Invest. (1998) [Pubmed]
  8. Repair of protease-damaged elastin in neonatal rat aortic smooth muscle cell cultures. Stone, P.J., Morris, S.M., Martin, B.M., McMahon, M.P., Faris, B., Franzblau, C. J. Clin. Invest. (1988) [Pubmed]
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  14. Mycobacterium chelonae tenosynovitis of the hand. Mateo, L., Rufí, G., Nolla, J.M., Alcaide, F. Semin. Arthritis Rheum. (2004) [Pubmed]
  15. Scedosporium prolificans osteomyelitis in an immunocompetent child treated with voriconazole and caspofungin, as well as locally applied polyhexamethylene biguanide. Steinbach, W.J., Schell, W.A., Miller, J.L., Perfect, J.R. J. Clin. Microbiol. (2003) [Pubmed]
  16. Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium. Saika, S., Okada, Y., Miyamoto, T., Yamanaka, O., Ohnishi, Y., Ooshima, A., Liu, C.Y., Weng, D., Kao, W.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  17. Integrins in the wounded and unwounded stratified squamous epithelium of the cornea. Stepp, M.A., Spurr-Michaud, S., Gipson, I.K. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  18. Expression of fibronectin isoforms bearing the alternatively spliced EIIIA, EIIIB, and V segments in corneal alkali burn and keratectomy wound models in the rat. Havrlikova, K., Mellott, M., Kaufman, A.H., Loredo, G.A., Peters, J.H., Colvin, R.B., Foster, C.S. Cornea (2004) [Pubmed]
  19. Frozen allogeneic human epidermal cultured sheets for the cure of complicated leg ulcers. Bolívar-Flores, Y.J., Kuri-Harcuch, W. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1999) [Pubmed]
  20. Results of 268 pressure sores in 158 patients managed jointly by plastic surgery and rehabilitation medicine. Kierney, P.C., Engrav, L.H., Isik, F.F., Esselman, P.C., Cardenas, D.D., Rand, R.P. Plast. Reconstr. Surg. (1998) [Pubmed]
  21. Prevention of stromal ulceration in the alkali-burned rabbit cornea by glued-on contact lens. Evidence for the role of polymorphonuclear leukocytes in collagen degradation. Kenyon, K.R., Berman, M., Rose, J., Gage, J. Invest. Ophthalmol. Vis. Sci. (1979) [Pubmed]
  22. Aspergillus quadrilineatus, a new causative agent of fungal sinusitis. Polacheck, I., Nagler, A., Okon, E., Drakos, P., Plaskowitz, J., Kwon-Chung, K.J. J. Clin. Microbiol. (1992) [Pubmed]
  23. Intraabdominal zygomycosis caused by Syncephalastrum racemosum infection successfully treated with partial surgical debridement and high-dose amphotericin B lipid complex. Schlebusch, S., Looke, D.F. J. Clin. Microbiol. (2005) [Pubmed]
  24. Zygomycosis in the 1990s in a tertiary-care cancer center. Kontoyiannis, D.P., Wessel, V.C., Bodey, G.P., Rolston, K.V. Clin. Infect. Dis. (2000) [Pubmed]
  25. Intracranial infection after missile injuries to the brain: report of 30 cases from the Lebanese conflict. Taha, J.M., Haddad, F.S., Brown, J.A. Neurosurgery (1991) [Pubmed]
  26. Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair. Nanney, L.B., Mueller, S.G., Bueno, R., Peiper, S.C., Richmond, A. Am. J. Pathol. (1995) [Pubmed]
  27. 'Punch' actinomycosis causing osteomyelitis of the hand. Blinkhorn, R.J., Strimbu, V., Effron, D., Spagnuolo, P.J. Arch. Intern. Med. (1988) [Pubmed]
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  30. Factors contributing to fatal outcome after treatment of pancreatic abscess. Malangoni, M.A., Richardson, J.D., Shallcross, J.C., Seiler, J.G., Polk, H.C. Ann. Surg. (1986) [Pubmed]
  31. Sonic hedgehog expression and role in healing corneal epithelium. Saika, S., Muragaki, Y., Okada, Y., Miyamoto, T., Ohnishi, Y., Ooshima, A., Kao, W.W. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  32. Local cutaneous necrotizing lesions associated with interferon injections. Krainick, U., Kantarjian, H., Broussard, S., Talpaz, M. J. Interferon Cytokine Res. (1998) [Pubmed]
  33. Expression changes of gelatinases in human osteoarthritic knees and arthroscopic debridement. Hsieh, Y.S., Yang, S.F., Chu, S.C., Chen, P.N., Chou, M.C., Hsu, M.C., Lu, K.H. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (2004) [Pubmed]
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  35. Effect of wound type on Smad 2 and 4 translocation. Hutcheon, A.E., Guo, X.Q., Stepp, M.A., Simon, K.J., Weinreb, P.H., Violette, S.M., Zieske, J.D. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  36. Mucormycosis in systemic lupus erythematosus. Mok, C.C., Que, T.L., Tsui, E.Y., Lam, W.Y. Semin. Arthritis Rheum. (2003) [Pubmed]
  37. Management of blunt liver trauma in children. Losty, P.D., Okoye, B.O., Walter, D.P., Turnock, R.R., Lloyd, D.A. The British journal of surgery. (1997) [Pubmed]
  38. Comparison of serum and tissue antibiotic levels in diabetes-related foot infections. Seabrook, G.R., Edmiston, C.E., Schmitt, D.D., Krepel, C., Bandyk, D.F., Towne, J.B. Surgery (1991) [Pubmed]
  39. Disposition of alfentanil in burns patients. Macfie, A.G., Magides, A.D., Reilly, C.S. British journal of anaesthesia. (1992) [Pubmed]
  40. Cutaneous mucormycosis resembling superficial granulomatous pyoderma in an immunocompetent host. Geller, J.D., Peters, M.S., Su, W.P. J. Am. Acad. Dermatol. (1993) [Pubmed]
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