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MeSH Review

Reflex, Pupillary

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High impact information on Reflex, Pupillary

  • Alfentanil blocks reflex pupillary dilation in response to noxious stimulation but does not diminish the light reflex [1].
  • The Bispectral Index (PK = 0.86), 95% spectral edge frequency (PK = 0.81), pupillary reflex amplitude (PK = 0.74), and systolic arterial blood pressure (PK = 0.78) did not differ significantly from modeled propofol effect-site concentration (PK = 0.76) in their ability to predict movement [2].
  • Unlike atropine, propantheline and methylscopolamine, pirenzepine is effective in preventing gastric erosions at doses much lower than those that affect pupillary reflex [3].
  • We examined the latency of pupillary reflex dilation and the effect of fentanyl on the latency of reflex dilation during anesthesia in nine volunteers [4].
  • The findings suggest that PACAP plays a role as neurotransmitter in non-imaging photoperception to target areas in the brain regulating circadian timing, masking, regulation of sleep-wake cycle and pupillary reflex [5].

Anatomical context of Reflex, Pupillary

  • We conclude that pupillary reflex dilation during anesthesia is not initiated by slowly conducting C fibers and that fentanyl depresses the reflex in a stereotypical manner [4].

Associations of Reflex, Pupillary with chemical compounds


Gene context of Reflex, Pupillary

  • Stimulation and recording of dynamic pupillary reflex: the IRIS technique. Part 2 [10].
  • CONCLUSION: Significant predictors of outcome were GCS on arrival in the accident emergency department, pupillary reflex and the CT scan findings [11].
  • SLE patients with increased systemic inflammation had an activated HANS axis which can be measured by a parasympathetic pupillary reflex test [12].


  1. Alfentanil blocks reflex pupillary dilation in response to noxious stimulation but does not diminish the light reflex. Larson, M.D., Kurz, A., Sessler, D.I., Dechert, M., Bjorksten, A.R., Tayefeh, F. Anesthesiology (1997) [Pubmed]
  2. Prediction of movement during propofol/nitrous oxide anesthesia. Performance of concentration, electroencephalographic, pupillary, and hemodynamic indicators. Leslie, K., Sessler, D.I., Smith, W.D., Larson, M.D., Ozaki, M., Blanchard, D., Crankshaw, D.P. Anesthesiology (1996) [Pubmed]
  3. Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat. Daniotti, S., Del Soldato, P. Br. J. Pharmacol. (1984) [Pubmed]
  4. Latency of pupillary reflex dilation during general anesthesia. Larson, M.D., Berry, P.D., May, J., Bjorksten, A., Sessler, D.I. J. Appl. Physiol. (2004) [Pubmed]
  5. Target areas innervated by PACAP-immunoreactive retinal ganglion cells. Hannibal, J., Fahrenkrug, J. Cell Tissue Res. (2004) [Pubmed]
  6. Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia. Larson, M.D., Talke, P.O. British journal of clinical pharmacology. (2001) [Pubmed]
  7. Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables. Constant, I., Nghe, M.C., Boudet, L., Berniere, J., Schrayer, S., Seeman, R., Murat, I. British journal of anaesthesia. (2006) [Pubmed]
  8. The effect of antiemetics on pupillary reflex dilation during epidural/general anesthesia. Larson, M.D. Anesth. Analg. (2003) [Pubmed]
  9. Dynamic evaluation by TV-pupillometry of the mydriatic effect of ibopamine solution. Controlled studies. Micieli, G., Tassorelli, C., Iannacchero, R., Lodola, E., Barbieri, P., Nappi, G. Arzneimittel-Forschung. (1990) [Pubmed]
  10. Stimulation and recording of dynamic pupillary reflex: the IRIS technique. Part 2. Reulen, J.P., Marcus, J.T., van Gilst, M.J., Koops, D., Bos, J.E., Tiesinga, G., de Vries, F.R., Boshuizen, K. Medical & biological engineering & computing. (1988) [Pubmed]
  11. Computed tomography of the brain in predicting outcome of traumatic intracranial haemorrhage in Malaysian patients. Azian, A.A., Nurulazman, A.A., Shuaib, L., Mahayidin, M., Ariff, A.R., Naing, N.N., Abdullah, J. Acta neurochirurgica. (2001) [Pubmed]
  12. Association of pupillary parasympathetic hyperreflexia and systemic inflammation in patients with systemic lupus erythematosus. Straub, R.H., Glück, T., Zeuner, M., Schölmerich, J., Lang, B. Br. J. Rheumatol. (1998) [Pubmed]
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