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Chemical Compound Review

Precedex     4-[(1R)-1-(2,3- dimethylphenyl)ethyl]-3H...

Synonyms: l-Medetomidine, CHEBI:48555, SureCN12092460, CHEBI:487941, AC1Q4WOC, ...
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Disease relevance of MPV 1440


Psychiatry related information on MPV 1440


High impact information on MPV 1440


Chemical compound and disease context of MPV 1440


Biological context of MPV 1440


Anatomical context of MPV 1440


Associations of MPV 1440 with other chemical compounds

  • In both cell types, the alpha(2B)-AR is coupled to G protein, and its stimulation by dexmedetomidine, but not by UK-14304, provoked a significant inhibition of the accumulation of cAMP induced by forskolin or parathyroid hormone [26].
  • Dexmedetomidine at 100 nM inhibited both AVP- and 8CPTcAMP-stimulated Pf [27].
  • In the EEDQ experiments, the analgesic response to dexmedetomidine was restored to normal when 44% of the alpha 2 adrenoceptors in the spinal cord were available for agonist binding; comparatively more alpha 2 adrenoceptors (77%) were required for the analgesic response to clonidine to be restored [28].
  • CONCLUSIONS: Dexmedetomidine reduced propofol requirements and improved hemodynamic stability during bispectral index-guided intensive care unit sedation [29].
  • The effect of local introduction of the alpha2-adrenoceptor agonist dexmedetomidine (10-9-10-8 m) on noradrenaline and dopamine release was investigated in alpha2A-adrenoceptor knockout and control mice by using in vivo microdialysis [30].

Gene context of MPV 1440

  • Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype [31].
  • Addition of dexmedetomidine (10 microM), an alpha 2-adrenergic agonist, did not change the baseline release of either CGRP or SP, but significantly decreased the CAP-evoked release of both peptides [32].
  • The administration of the alpha 2-agonist, dexmedetomidine, to HTM cells resulted in a 90% inhibition of forskolin-stimulated cAMP formation, a twofold stimulation of MAP kinase activity, and a threefold increase in the expression of PCNA [33].
  • METHODS: The effects of dexmedetomidine on phospho-tyrosine FAK phosphorylation were studied first with or without various pharmacologic agents in normoxic conditions, and second in a model of pharmacologic preconditioning of slices subjected to 30 min of OGD followed by 1 h of reperfusion [34].
  • CONCLUSIONS: The present data demonstrate that dexmedetomidine effectively prevents delayed neuronal death in CA3 area and in the dentate hilus in gerbil hippocampus when the management is started before the onset of ischemia and continued for 48 h after reperfusion [35].

Analytical, diagnostic and therapeutic context of MPV 1440


  1. Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: a possible mechanism for its neuroprotective activity. Huang, R., Chen, Y., Yu, A.C., Hertz, L. J. Cereb. Blood Flow Metab. (2000) [Pubmed]
  2. Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Fujinaga, M., Maze, M., Hoffman, B.B., Baden, J.M. Dev. Biol. (1992) [Pubmed]
  3. Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. Vartiainen, J., MacDonald, E., Urtti, A., Rouhiainen, H., Virtanen, R. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  4. Anesthetic profile of dexmedetomidine identified by stimulus-response and continuous measurements in rats. Bol, C.J., Vogelaar, J.P., Mandema, J.W. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  5. Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Furst, S.R., Weinger, M.B. Anesthesiology (1990) [Pubmed]
  6. Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist. Sallinen, J., Link, R.E., Haapalinna, A., Viitamaa, T., Kulatunga, M., Sjöholm, B., Macdonald, E., Pelto-Huikko, M., Leino, T., Barsh, G.S., Kobilka, B.K., Scheinin, M. Mol. Pharmacol. (1997) [Pubmed]
  7. Dexmedetomidine injection into the locus ceruleus produces antinociception. Guo, T.Z., Jiang, J.Y., Buttermann, A.E., Maze, M. Anesthesiology (1996) [Pubmed]
  8. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers. Scheinin, H., Aantaa, R., Anttila, M., Hakola, P., Helminen, A., Karhuvaara, S. Anesthesiology (1998) [Pubmed]
  9. Dexmedetomidine does not improve patient satisfaction when compared with propofol during mechanical ventilation. Corbett, S.M., Rebuck, J.A., Greene, C.M., Callas, P.W., Neale, B.W., Healey, M.A., Leavitt, B.J. Crit. Care Med. (2005) [Pubmed]
  10. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Levänen, J., Mäkelä, M.L., Scheinin, H. Anesthesiology (1995) [Pubmed]
  11. Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. Mizobe, T., Maghsoudi, K., Sitwala, K., Tianzhi, G., Ou, J., Maze, M. J. Clin. Invest. (1996) [Pubmed]
  12. alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation. Cussac, D., Schaak, S., Denis, C., Paris, H. J. Biol. Chem. (2002) [Pubmed]
  13. Optimizing outcomes in bariatric surgery: outpatient laparoscopic gastric bypass. McCarty, T.M., Arnold, D.T., Lamont, J.P., Fisher, T.L., Kuhn, J.A. Ann. Surg. (2005) [Pubmed]
  14. Dexmedetomidine decreases cerebral blood flow velocity in humans. Zornow, M.H., Maze, M., Dyck, J.B., Shafer, S.L. J. Cereb. Blood Flow Metab. (1993) [Pubmed]
  15. Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. Laudenbach, V., Mantz, J., Lagercrantz, H., Desmonts, J.M., Evrard, P., Gressens, P. Anesthesiology (2002) [Pubmed]
  16. Propofol-induced dyskinesias controlled with dexmedetomidine during deep brain stimulation surgery. Deogaonkar, A., Deogaonkar, M., Lee, J.Y., Ebrahim, Z., Schubert, A. Anesthesiology (2006) [Pubmed]
  17. Effect of the alpha2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Engelhard, K., Werner, C., Kaspar, S., Möllenberg, O., Blobner, M., Bachl, M., Kochs, E. Anesthesiology (2002) [Pubmed]
  18. Mechanism of antiarrhythmic effect of dexmedetomidine on epinephrine-induced arrhythmias. Eisenach, J.C. Anesthesiology (1991) [Pubmed]
  19. Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine. Scheinin, H., Karhuvaara, S., Olkkola, K.T., Kallio, A., Anttila, M., Vuorilehto, L., Scheinin, M. Clin. Pharmacol. Ther. (1992) [Pubmed]
  20. Dexmedetomidine. Bhana, N., Goa, K.L., McClellan, K.J. Drugs (2000) [Pubmed]
  21. Autonomic nervous system responses during sedative infusions of dexmedetomidine. Hogue, C.W., Talke, P., Stein, P.K., Richardson, C., Domitrovich, P.P., Sessler, D.I. Anesthesiology (2002) [Pubmed]
  22. Systemically administered alpha2-agonist-induced peripheral vasoconstriction in humans. Talke, P., Lobo, E., Brown, R. Anesthesiology (2003) [Pubmed]
  23. Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Graham, B.A., Hammond, D.L., Proudfit, H.K. Pain (2000) [Pubmed]
  24. Noradrenergic regulation of hippocampal place cells. Tanila, H. Hippocampus. (2001) [Pubmed]
  25. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Jalonen, J., Hynynen, M., Kuitunen, A., Heikkilä, H., Perttilä, J., Salmenperä, M., Valtonen, M., Aantaa, R., Kallio, A. Anesthesiology (1997) [Pubmed]
  26. alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells. Cussac, D., Schaak, S., Gales, C., Flordellis, C., Denis, C., Paris, H. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  27. Indomethacin and staurosporine reverse alpha 2 inhibition of water transport in rat IMCD. Rouch, A.J., Kudo, L.H. Kidney Int. (1997) [Pubmed]
  28. Desensitization to the behavioral effects of alpha 2-adrenergic agonists in rats. Hayashi, Y., Guo, T.Z., Maze, M. Anesthesiology (1995) [Pubmed]
  29. Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Triltsch, A.E., Welte, M., von Homeyer, P., Grosse, J., Genähr, A., Moshirzadeh, M., Sidiropoulos, A., Konertz, W., Kox, W.J., Spies, C.D. Crit. Care Med. (2002) [Pubmed]
  30. In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse prefrontal cortex. Ihalainen, J.A., Tanila, H. Eur. J. Neurosci. (2002) [Pubmed]
  31. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Ma, D., Hossain, M., Rajakumaraswamy, N., Arshad, M., Sanders, R.D., Franks, N.P., Maze, M. Eur. J. Pharmacol. (2004) [Pubmed]
  32. Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Takano, M., Takano, Y., Yaksh, T.L. Peptides (1993) [Pubmed]
  33. Cultured human trabecular meshwork cells express functional alpha 2A adrenergic receptors. Stamer, W.D., Huang, Y., Seftor, R.E., Svensson, S.S., Snyder, R.W., Regan, J.W. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  34. Effects of dexmedetomidine on hippocampal focal adhesion kinase tyrosine phosphorylation in physiologic and ischemic conditions. Dahmani, S., Rouelle, D., Gressens, P., Mantz, J. Anesthesiology (2005) [Pubmed]
  35. Neuroprotective effects of dexmedetomidine in the gerbil hippocampus after transient global ischemia. Kuhmonen, J., Pokorný, J., Miettinen, R., Haapalinna, A., Jolkkonen, J., Riekkinen, P., Sivenius, J. Anesthesiology (1997) [Pubmed]
  36. Effects of dexmedetomidine, a selective alpha 2-adrenoceptor agonist, on hemodynamic control mechanisms. Kallio, A., Scheinin, M., Koulu, M., Ponkilainen, R., Ruskoaho, H., Viinamäki, O., Scheinin, H. Clin. Pharmacol. Ther. (1989) [Pubmed]
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