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MeSH Review

Tilt-Table Test

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Disease relevance of Tilt-Table Test


High impact information on Tilt-Table Test

  • SETTING: Two tertiary referral centers in the United States. PATIENTS: One hundred individuals aged 18 to 50 years who satisfied Centers for Disease Control and Prevention criteria for CFS and had NMH provoked during a 2-stage tilt-table test [6].
  • INTERVENTIONS--Each subject completed a symptom questionnaire and underwent a three-stage upright tilt-table test (stage 1, 45 minutes at 70 degrees tilt; stage 2, 15 minutes at 70 degrees tilt with 1 to 2 micrograms/min of isoproterenol; and stage 3, 10 minutes at 70 degrees with 3 to 4 micrograms/min of isoproterenol) [7].
  • All tilt-positive patients received therapy with either beta-blockers, disopyramide, transdermal scopolamine, or hydroflurocortisone, the efficacy of which was evaluated by another tilt-table test [8].
  • Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience [9].
  • METHODS AND RESULTS: Thirty subjects who had reproducible NMS induced with head-up tilt table test (HUT) were randomly assigned and divided in double-blind fashion into placebo and enalapril (an ACE inhibitor) groups [10].

Biological context of Tilt-Table Test


Associations of Tilt-Table Test with chemical compounds


Gene context of Tilt-Table Test

  • METHODS AND RESULTS: Ten untreated consecutive LQTS patients (age 11-72 years, median 37.5 years, five males and five females from five different families (one KvLQT1 mutation, two HERG mutations in three families and one without established genetic background)) were examined by a head-up tilt-table test (HUT) [13].


  1. Risk factors for syncope recurrence after a positive tilt-table test in patients with syncope. Sheldon, R., Rose, S., Flanagan, P., Koshman, M.L., Killam, S. Circulation (1996) [Pubmed]
  2. Cerebral vasoconstriction during head-upright tilt-induced vasovagal syncope. A paradoxic and unexpected response. Grubb, B.P., Gerard, G., Roush, K., Temesy-Armos, P., Montford, P., Elliott, L., Hahn, H., Brewster, P. Circulation (1991) [Pubmed]
  3. Prospective evaluation of a two-step therapeutic strategy in neurocardiogenic syncope: midodrine as second line treatment in patients refractory to beta-blockers. Klingenheben, T., Credner, S., Hohnloser, S.H. Pacing and clinical electrophysiology : PACE. (1999) [Pubmed]
  4. Significant complications can occur with ischemic heart disease and tilt table testing. Leman, R.B., Clarke, E., Gillette, P. Pacing and clinical electrophysiology : PACE. (1999) [Pubmed]
  5. Effect of stress on cardiovascular regulation in neurological diseases with dysautonomia. Frontoni, M., Giubilei, F., Millefiorini, E., Antonini, G., Fiorini, M., Vichi, R., Urani, C., Strano, S., Fieschi, C. Acta neurologica. (1991) [Pubmed]
  6. Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial. Rowe, P.C., Calkins, H., DeBusk, K., McKenzie, R., Anand, R., Sharma, G., Cuccherini, B.A., Soto, N., Hohman, P., Snader, S., Lucas, K.E., Wolff, M., Straus, S.E. JAMA (2001) [Pubmed]
  7. The relationship between neurally mediated hypotension and the chronic fatigue syndrome. Bou-Holaigah, I., Rowe, P.C., Kan, J., Calkins, H. JAMA (1995) [Pubmed]
  8. Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin. Grubb, B.P., Temesy-Armos, P., Hahn, H., Elliott, L. Am. J. Med. (1991) [Pubmed]
  9. Unprovoked and glyceryl trinitrate-provoked head-up tilt table test is safe in older people: a review of 10 years' experience. Gieroba, Z.J., Newton, J.L., Parry, S.W., Norton, M., Lawson, J., Kenny, R.A. Journal of the American Geriatrics Society. (2004) [Pubmed]
  10. Randomized, double-blind, placebo-controlled trial of oral enalapril in patients with neurally mediated syncope. Zeng, C., Zhu, Z., Liu, G., Hu, W., Wang, X., Yang, C., Wang, H., He, D., Tan, J. Am. Heart J. (1998) [Pubmed]
  11. Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS. Saari, A., Tolonen, U., Pääkkö, E., Suominen, K., Pyhtinen, J., Sotaniemi, K., Myllylä, V. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004) [Pubmed]
  12. Results of isoproterenol tilt table testing in monozygotic twins discordant for chronic fatigue syndrome. Poole, J., Herrell, R., Ashton, S., Goldberg, J., Buchwald, D. Arch. Intern. Med. (2000) [Pubmed]
  13. Long QT syndrome patients may faint due to neurocardiogenic syncope. Toft, E., Aarøe, J., Jensen, B.T., Christiansen, M., Fog, L., Thomsen, P.E., Kanters, J.K. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. (2003) [Pubmed]
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