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MeSH Review


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Disease relevance of Ectropion


High impact information on Ectropion

  • PURPOSE: To report a rare case of ocular anterior segment anomalies including uveal ectropion of the iris, invasion of the conjunctival epithelia into the cornea, and posterior embryotoxon with a missense mutation of the PAX6 gene [6].
  • CONCLUSIONS: Severe corneal damage can occur in LI even if there is no upper or lower eyelid ectropion [7].
  • Cicatricial ectropion: a complication of systemic fluorouracil [8].
  • Reversible ectropion after long-term use of topical tretinoin on photodamaged skin [9].
  • The vaginal and cervical cellular changes encountered in 575 postpubertal females exposed prenatally to diethylstilbestrol (DES) were compared with those of an unexposed population with particular reference to the role of cytology in the detection of vaginal adenosis and cervical ectropion (erosion) [10].

Chemical compound and disease context of Ectropion

  • Carbon dioxide (CO2) laser blepharoplasty with orbicularis oculi muscle tightening and periorbital skin resurfacing is a safe procedure that produces excellent aesthetic results and diminishes the occurrence of complications associated with skin and muscle resection in the lower lid, particularly permanent scleral show and ectropion [11].
  • Reversible lower eyelid ectropion associated with dipivefrin [12].
  • The "Diamond Head" graft for paralytic ectropion of the lower eyelid [13].
  • METHODS: Study of the possibility of performing surgery to repair medial ectropion using biodegradable polyglyconate Tag anchors was commenced in the sheep cadaveric head model, and in the whole dry human skull model [14].
  • RESULTS: Relief of cicatricial ectropion symptoms was reported in 90% of patients overall [15].

Anatomical context of Ectropion

  • The literature suggests that posterior polymorphous dystrophy (PPD) may show features such as iridocorneal adhesions, glassy membranes, and pupillary ectropion which are typically ascribed to the iridocorneal endothelial (ICE) syndrome [16].

Gene context of Ectropion

  • We described a patient with ectropion and the mutation R1748X in the NF1 gene [17].
  • Our preliminary findings showed a reduction of CD4, CD8 and CD1 lymphocytic subpopulations in ectropion zones, while these subpopulations are normally present in healthy zones of the exocervix [18].
  • RESULTS: Minor flap necrosis occurred in one patient and simple lower eyelid ectropion in another [19].
  • What's your diagnosis? Congenital iris ectropion syndrome associated with glaucoma [20].


  1. Blepharo-cheilo-dontic (BCD) syndrome in two Mexican patients. Valdéz-de la Torre, M.H., Quintana-García, M., Canún, S. Am. J. Med. Genet. (1999) [Pubmed]
  2. Atypical vaginal adenosis and cervical ectropion. Association with clear cell adenocarcinoma in diethylstilbestrol-exposed offspring. Robboy, S.J., Young, R.H., Welch, W.R., Truslow, G.Y., Prat, J., Herbst, A.L., Scully, R.E. Cancer (1984) [Pubmed]
  3. Low-dose methotrexate as an adjunctive therapy with surgery for ectropion complicating dermatomyositis. Abernethy, M.L., Arterberry, J.F., Callen, J.P. Dermatology (Basel) (1996) [Pubmed]
  4. Not just a cervical ectropion. Three case reports of diethylstilbestrol (DES) exposed women presenting with vaginal discharge and cervical ectropion. Wingfield, M. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. (1999) [Pubmed]
  5. Severe blepharoconjunctivitis induced by a peeling mask containing trichloroacetic acid. Kaiserman, I., Kaiserman, N. Ocul. Immunol. Inflamm. (2005) [Pubmed]
  6. Missense mutation at the C terminus of the PAX6 gene in ocular anterior segment anomalies. Azuma, N., Yamada, M. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  7. Eyelid abnormalities in lamellar ichthyoses. Cruz, A.A., Menezes, F.A., Chaves, R., Pinto Coelho, R., Velasco, E.F., Kikuta, H. Ophthalmology (2000) [Pubmed]
  8. Cicatricial ectropion: a complication of systemic fluorouracil. Hurwitz, B.S. Arch. Ophthalmol. (1993) [Pubmed]
  9. Reversible ectropion after long-term use of topical tretinoin on photodamaged skin. Brodell, L.P., Asselin, D., Brodell, R.T. J. Am. Acad. Dermatol. (1992) [Pubmed]
  10. Cytology of 575 young women with prenatal exposure to diethylstilbestrol. Robboy, S.J., Friedlander, L.M., Welch, W.R., Keh, P.C., Taft, P.D., Barnes, A.B., Scully, R.E., Herbst, A.L. Obstetrics and gynecology. (1976) [Pubmed]
  11. Laser blepharoplasty with transconjunctival orbicularis muscle/septum tightening and periocular skin resurfacing: a safe and advantageous technique. Seckel, B.R., Kovanda, C.J., Cetrulo, C.L., Passmore, A.K., Meneses, P.G., White, T. Plast. Reconstr. Surg. (2000) [Pubmed]
  12. Reversible lower eyelid ectropion associated with dipivefrin. Bartley, G.B. Am. J. Ophthalmol. (1991) [Pubmed]
  13. The "Diamond Head" graft for paralytic ectropion of the lower eyelid. Flowers, R.S., Caputy, G.G. Plast. Reconstr. Surg. (1994) [Pubmed]
  14. Stabilization of the posterior limb of the medial canthal tendon using biodegradable tag anchors: a cadaveric model. Francis, I.C., Walsh, W.R., Sonnabend, D.H., D'Mello 'AC, n.u.l.l., Coroneo, M.T. Ophthalmic plastic and reconstructive surgery. (2001) [Pubmed]
  15. Eyelid retractor surgery as an adjunct to cicatricial ectropion repair. O'Donnell, B.A. Clin. Experiment. Ophthalmol. (2000) [Pubmed]
  16. Distinguishing features of the iridocorneal endothelial syndrome and posterior polymorphous dystrophy: value of endothelial specular microscopy. Laganowski, H.C., Sherrard, E.S., Muir, M.G., Buckley, R.J. The British journal of ophthalmology. (1991) [Pubmed]
  17. Presence of the R1748X mutation in the NF1 gene in a Brazilian patient with ectropion uveae. Trovó-Marqui, A.B., Goloni-Bertollo, E.M., Teixeira, M.F., Tajara, E.H. Ophthalmic Res. (2004) [Pubmed]
  18. Cell-mediated immunity in the course of cervical ectropion. De Luca Brunori, I., Facchini, V., Filippeschi, M., Battini, L., Giusti, G., Romani, L., Scida, P., Urbano, M. Clinical and experimental obstetrics & gynecology. (1994) [Pubmed]
  19. Nasolabial V-Y advancement for closure of the midface defects. Yildirim, S., Aköz, T., Akan Md, n.u.l.l., Avci, G. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2001) [Pubmed]
  20. What's your diagnosis? Congenital iris ectropion syndrome associated with glaucoma. Walton, D.S. Journal of pediatric ophthalmology and strabismus. (2005) [Pubmed]
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