Disease relevance of Vaginal Discharge

• In a prospective, single-blind, randomized study, a single 2-g dose of metronidazole was compared with a seven-day course of 500 mg given twice daily in the treatment of symptomatic vaginal discharge associated with Gardnerella vaginalis [1].
• The potential effect on Neisseria gonorrhoeae of the use of clindamycin vaginal cream in the empirical treatment of vaginal discharge [2].
• RESULTS: There were no significant differences in the frequency of pruritus (55.9 vs. 56.7%), vaginal discharge (63.8 vs. 69.0%), dyspareunia (25.0 vs. 20.0%), and percentage yeast positivity (67.5 vs. 54.7%) between diabetic and control groups before the start of fluconazole therapy [3].
• CONCLUSIONS AND CLINICAL RELEVANCE: Parenteral administration of ceftiofur significantly improved cure rate, milk yield, and rectal temperature in postpartum cows with fever and vaginal discharge or dystocia [4].
• The possibility of tubal carcinoma should be considered in patients with persistent vaginal discharge and lower abdominal pain without apparent explanation [5].

High impact information on Vaginal Discharge

• Among the seven amines, putrescine and cadaverine were the most abundant and were present in all vaginal discharges from each of ten patients before treatment [6].
• The commonest side-effects were hot flushes (27% of patients receiving tamoxifen and 11% of those receiving placebo) and vaginal discharge (17% tamoxifen, 7% placebo) [7].
• Compared with patients receiving tamoxifen only, patients receiving anastrozole only reported significantly fewer cold sweats and vaginal discharge, yet more vaginal dryness, painful intercourse, and loss of sexual interest [8].
• A positive Candida culture increased vaginal IL-8 during menses, whereas vaginal discharge was associated with a reduction in vaginal IL-4, IL-10, and RANTES [9].
• The tolerability profile of toremifene is similar to that reported for tamoxifen, the most common adverse effects being hot flushes, sweating, nausea and/or vomiting, dizziness, oedema, and vaginal discharge and/or bleeding [10].

Chemical compound and disease context of Vaginal Discharge

• This antibacterial activity may give fenticonazole a useful role in the topical treatment of vaginal discharge and in mycotic skin infections that are superinfected with bacteria [11].
• Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later [12].
• CONCLUSION: In this population of older, largely asymptomatic women, ultralow-dose transdermal estradiol did not improve postmenopausal symptoms and did not cause side effects other than vaginal discharge [13].
• Aphrodisin is a soluble glycoprotein of hamster vaginal discharges, which stimulates male copulatory behavior [14].
• Vaginal discharge or irritation were reported by 10.5% of patients given micronised progesterone [15].

Biological context of Vaginal Discharge

• Ovarian EGF content peaked (17 +/- 2 pg/nonluteal ovary) on Day 1 (estrus as determined by copious vaginal discharge) and declined by DAy 3 as measured by RIA of immunoaffinity-purified ovarian extract [16].
• Chemotaxis inhibition by Gardnerella vaginalis and succinate producing vaginal anaerobes: composition of vaginal discharge associated with G vaginalis [17].

Anatomical context of Vaginal Discharge

• Although increased vaginal discharge occurs with treatment, clinicians often presume the effects of tamoxifen on the vaginal epithelium are antiestrogenic [18].

Gene context of Vaginal Discharge

• STUDY DESIGN: Lactoferrin was quantified in the vaginal discharge of women with genital infections [19].
• A careful consideration of the history of pain, vaginal discharge, and pelvic mass is most important in making this diagnosis of tubal cancer preoperatively, along with a high index of clinical suspicion [20].
• Moreover, 22-1-1 Ag was associated in the vaginal discharges of uterine cervical carcinoma patients [21].
• The presence of a purulent vaginal discharge decreased the number of animals with a corpus luteum in the ovary contralateral to the PGUH (45/143 vs. 60/141; P<0.05), but not in the ovary ipsilateral to the PGUH [22].
• A collection of 72 strains of catalase-negative gram-positive, -negative and -variable cocco-bacilli isolated from samples of vaginal discharge from women with non-specific vaginal infection was examined in an attempt to develop an identification system for Gardnerella vaginalis that could be used in a diagnostic laboratory [23].

Analytical, diagnostic and therapeutic context of Vaginal Discharge

• Polyacrylamide gel electrophoresis of vaginal lavages showed that the endocrine status of females has a profound effect on the protein composition of the vaginal discharge [24].
• The relevance of volatile fatty acids as a diagnostic test in 79 women with abnormal vaginal discharge was evaluated by a blind, randomised, and placebo controlled trial of tinidazole as a single oral 2 g dose [25].
• Her vaginal discharge was positive for Trichomonas vaginalis, both on wet mount and Papanicolaou smear, and the infection responded well to treatment with metronidazole [26].
• From randomized controlled trials of adjuvant therapy, we know that tamoxifen therapy increases the rate of hot flashes, night sweats, and vaginal discharge; however, in observational studies these symptoms do not have a statistically significant impact on patients' quality of life as measured by standardized, self-report questionnaires [27].

References