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MeSH Review


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Disease relevance of Arterivirus


High impact information on Arterivirus


Biological context of Arterivirus


Gene context of Arterivirus

  • Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease [2].
  • Thus, contribution to the formation of a membrane-bound scaffold for the viral replication-transcription complex appears to be an important novel function for the arterivirus ORF1a replicase polyprotein [11].
  • Autoantibodies against golgi apparatus induced by arteriviruses [12].

Analytical, diagnostic and therapeutic context of Arterivirus

  • Sequence alignments and protein secondary structure prediction data suggest the presence of a 3C-like serine protease domain with similarity to the arterivirus 3C-like serine protease and a single papain-like cysteine protease domain with similarity to the picornavirus leader protease [13].


  1. Structural proteins of equine arteritis virus. de Vries, A.A., Chirnside, E.D., Horzinek, M.C., Rottier, P.J. J. Virol. (1992) [Pubmed]
  2. Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. Wassenaar, A.L., Spaan, W.J., Gorbalenya, A.E., Snijder, E.J. J. Virol. (1997) [Pubmed]
  3. Lactate dehydrogenase-elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive-strand RNA viruses. Plagemann, P.G., Moennig, V. Adv. Virus Res. (1992) [Pubmed]
  4. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. Albina, E., Carrat, C., Charley, B. J. Interferon Cytokine Res. (1998) [Pubmed]
  5. The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases. Snijder, E.J., Wassenaar, A.L., van Dinten, L.C., Spaan, W.J., Gorbalenya, A.E. J. Biol. Chem. (1996) [Pubmed]
  6. The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. Snijder, E.J., Wassenaar, A.L., Spaan, W.J., Gorbalenya, A.E. J. Biol. Chem. (1995) [Pubmed]
  7. Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing. van Aken, D., Snijder, E.J., Gorbalenya, A.E. J. Virol. (2006) [Pubmed]
  8. Porcine arterivirus infection of alveolar macrophages is mediated by sialic acid on the virus. Delputte, P.L., Nauwynck, H.J. J. Virol. (2004) [Pubmed]
  9. Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity. Snijder, E.J., Dobbe, J.C., Spaan, W.J. J. Virol. (2003) [Pubmed]
  10. Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication. van Dinten, L.C., Rensen, S., Gorbalenya, A.E., Snijder, E.J. J. Virol. (1999) [Pubmed]
  11. ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex. van der Meer, Y., van Tol, H., Locker, J.K., Snijder, E.J. J. Virol. (1998) [Pubmed]
  12. Autoantibodies against golgi apparatus induced by arteriviruses. Weiland, E., Weiland, F. Cell. Mol. Biol. (Noisy-le-grand) (2002) [Pubmed]
  13. The complete sequence of the bovine torovirus genome. Draker, R., Roper, R.L., Petric, M., Tellier, R. Virus Res. (2006) [Pubmed]
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