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Disease relevance of Lyssavirus


High impact information on Lyssavirus

  • Proteomic knowledge concerning the functional network of interactions in the lyssavirus transcription-replication complex highlights the phosphoprotein (P) as a prime target for inhibitors of viral replication [3].
  • No lyssavirus nucleocapsid was detected in 1,283 brains tested by immunofluorescence assay [4].
  • We also demonstrated that the decapsidation and replication of lyssavirus are essential for inducing apoptosis, as supported by UV inactivation, cycloheximide treatment, and the use of bafilomycin A1 to inhibit endosomal acidification [5].
  • Glycoprotein segments accumulating more d(N) than d(S) were distinctly detected in carnivoran and chiropteran lyssaviruses [6].
  • We investigated the production efficiency and the gene transfer capacity in the central nervous system of HIV-1-based vectors pseudotyped with either the G protein of the Mokola lyssaviruses (MK-G), a neurotropic virus causing rabies disease, or the vesiculo-stomatitis G protein (VSV-G) [7].

Chemical compound and disease context of Lyssavirus


Biological context of Lyssavirus


Gene context of Lyssavirus

  • Analysis using nucleocapsid (N) specific monoclonal antibodies, showed a strong relationship between this new lyssavirus and serotype 1 rabies [13].
  • Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein [15].
  • The initial biologically active IL2 and cytokine mRNA production was observed in mice infected with pathogenic or non-pathogenic lyssaviruses [16].
  • The high degree of sequence divergence between these P proteins (only 46% amino acid identity) favors the hypothesis that this interaction is a common property shared by all lyssaviruses [15].
  • The sequence of 5568 nucleotides of the 3' moiety of the Mokola virus genome (serotype 3 of lyssaviruses) encompassing the nucleoprotein (N), phosphoprotein, matrix protein, and glycoprotein genes is presented and compared to that of the vaccinal strains of serotype 1 [12].


  1. Differential stability and fusion activity of Lyssavirus glycoprotein trimers. Desmézières, E., Maillard, A.P., Gaudin, Y., Tordo, N., Perrin, P. Virus Res. (2003) [Pubmed]
  2. Viruses isolated from reptiles: identification of three new members of the family Rhabdoviridae. Monath, T.P., Cropp, C.B., Frazier, C.L., Murphy, F.A., Whitfield, S.G. Arch. Virol. (1979) [Pubmed]
  3. Antiviral drug discovery strategy using combinatorial libraries of structurally constrained peptides. Real, E., Rain, J.C., Battaglia, V., Jallet, C., Perrin, P., Tordo, N., Chrisment, P., D'Alayer, J., Legrain, P., Jacob, Y. J. Virol. (2004) [Pubmed]
  4. Serologic evidence of lyssavirus infection in bats, Cambodia. Reynes, J.M., Molia, S., Audry, L., Hout, S., Ngin, S., Walston, J., Bourhy, H. Emerging Infect. Dis. (2004) [Pubmed]
  5. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. Kassis, R., Larrous, F., Estaquier, J., Bourhy, H. J. Virol. (2004) [Pubmed]
  6. Host switching in Lyssavirus history from the Chiroptera to the Carnivora orders. Badrane, H., Tordo, N. J. Virol. (2001) [Pubmed]
  7. Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins. Desmaris, N., Bosch, A., Salaün, C., Petit, C., Prévost, M.C., Tordo, N., Perrin, P., Schwartz, O., de Rocquigny, H., Heard, J.M. Mol. Ther. (2001) [Pubmed]
  8. Detection and strain differentiation of European bat lyssaviruses using in situ hybridisation. Finnegan, C.J., Brookes, S.M., Johnson, L., Fooks, A.R. J. Virol. Methods (2004) [Pubmed]
  9. Cross-reactive antigenicity of nucleoproteins of lyssaviruses recognized by a monospecific antirabies virus nucleoprotein antiserum on paraffin sections of formalin-fixed tissues. Inoue, S., Sato, Y., Hasegawa, H., Noguchi, A., Yamada, A., Kurata, T., Iwasaki, T. Pathol. Int. (2003) [Pubmed]
  10. Rabies prophylaxis in Western Australia: the impact of Australian bat lyssavirus. Torvaldsen, S., Watson, T. Commun. Dis. Intell. (1998) [Pubmed]
  11. The complete Mokola virus genome sequence: structure of the RNA-dependent RNA polymerase. Le Mercier, P., Jacob, Y., Tordo, N. J. Gen. Virol. (1997) [Pubmed]
  12. Molecular diversity of the Lyssavirus genus. Bourhy, H., Kissi, B., Tordo, N. Virology (1993) [Pubmed]
  13. Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia. Gould, A.R., Hyatt, A.D., Lunt, R., Kattenbelt, J.A., Hengstberger, S., Blacksell, S.D. Virus Res. (1998) [Pubmed]
  14. Molecular epidemiology of lyssaviruses: focus on the glycoprotein and pseudogenes. Tordo, N., Badrane, H., Bourhy, H., Sacramento, D. Onderstepoort J. Vet. Res. (1993) [Pubmed]
  15. Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein. Jacob, Y., Badrane, H., Ceccaldi, P.E., Tordo, N. J. Virol. (2000) [Pubmed]
  16. The antigen-specific cell-mediated immune response in mice is suppressed by infection with pathogenic lyssaviruses. Perrin, P., Tino de Franco, M., Jallet, C., Fouque, F., Morgeaux, S., Tordo, N., Colle, J.H. Res. Virol. (1996) [Pubmed]
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