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Gene Review

N  -  nucleocapsid protein

Australian bat lyssavirus

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Disease relevance of N


High impact information on N


Chemical compound and disease context of N


Biological context of N


Anatomical context of N


Associations of N with chemical compounds

  • The percent relatedness of the ABLV proteins when compared to the cognate proteins of PV (Pasteur vaccine strain) rabies was 92, 75, 87 and 75% for the N, P, M and G proteins, respectively [1].
  • Infected cells were lysed with a deoxycholate-free lysis buffer and separated by ultracentrifugation into the soluble top and the nucleocapsid fractions [15].
  • The protein was either purified on a CsCl gradient, resulting in a mixture of nucleocapsid-like structures and beaded rings, as observed by electron microscopy, or on a glycerol gradient that resulted in a preparation of the rings only [16].

Other interactions of N

  • When the P proteins were released from the NC, however, they were no longer recognized by the mAb [2].

Analytical, diagnostic and therapeutic context of N


  1. Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia. Gould, A.R., Hyatt, A.D., Lunt, R., Kattenbelt, J.A., Hengstberger, S., Blacksell, S.D. Virus Res. (1998) [Pubmed]
  2. Structural relationship between nucleocapsid-binding activity of the rabies virus phosphoprotein (P) and exposure of epitope 402-13 located at the C terminus. Toriumi, H., Honda, Y., Morimoto, K., Tochikura, T.S., Kawai, A. J. Gen. Virol. (2002) [Pubmed]
  3. Rabies mRNA translation in Xenopus laevis oocytes. Wunner, W.H., Curtis, P.J., Wiktor, T.J. J. Virol. (1980) [Pubmed]
  4. The structural proteins of rabies virus and evidence for their synthesis from separate monocistronic RNA species. Coslett, G.D., Holloway, B.P., Obijeski, J.F. J. Gen. Virol. (1980) [Pubmed]
  5. A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARS-CoV-neutralizing antibodies. Faber, M., Lamirande, E.W., Roberts, A., Rice, A.B., Koprowski, H., Dietzschold, B., Schnell, M.J. J. Gen. Virol. (2005) [Pubmed]
  6. Evidence for a viral superantigen in humans. Lafon, M., Lafage, M., Martinez-Arends, A., Ramirez, R., Vuillier, F., Charron, D., Lotteau, V., Scott-Algara, D. Nature (1992) [Pubmed]
  7. Rabies superantigen as a Vbeta T-dependent adjuvant. Astoul, E., Lafage, M., Lafon, M. J. Exp. Med. (1996) [Pubmed]
  8. Neonatal deletion and selective expansion of mouse T cells by exposure to rabies virus nucleocapsid superantigen. Lafon, M., Scott-Algara, D., Marche, P.N., Cazenave, P.A., Jouvin-Marche, E. J. Exp. Med. (1994) [Pubmed]
  9. Isolation and characterization of human T cell lines and clones reactive to rabies virus: antigen specificity and production of interferon-gamma. Celis, E., Miller, R.W., Wiktor, T.J., Dietzschold, B., Koprowski, H. J. Immunol. (1986) [Pubmed]
  10. Antigenic diversity of the glycoprotein and nucleocapsid proteins of rabies and rabies-related viruses: implications for epidemiology and control of rabies. Dietzschold, B., Rupprecht, C.E., Tollis, M., Lafon, M., Mattei, J., Wiktor, T.J., Koprowski, H. Rev. Infect. Dis. (1988) [Pubmed]
  11. Nucleocapsid specific T and B cell responses in humans after rabies vaccination. Herzog, M., Lafage, M., Montaño-Hirose, J.A., Fritzell, C., Scott-Algara, D., Lafon, M. Virus Res. (1992) [Pubmed]
  12. Cytoplasmic dynein LC8 interacts with lyssavirus phosphoprotein. Jacob, Y., Badrane, H., Ceccaldi, P.E., Tordo, N. J. Virol. (2000) [Pubmed]
  13. Sequence of the major nucleocapsid protein gene of pneumonia virus of mice: sequence comparisons suggest structural homology between nucleocapsid proteins of pneumoviruses, paramyxoviruses, rhabdoviruses and filoviruses. Barr, J., Chambers, P., Pringle, C.R., Easton, A.J. J. Gen. Virol. (1991) [Pubmed]
  14. Further studies on rabies virus isolated from healthy dogs in Nigeria. Aghomo, H.O., Rupprecht, C.E. Vet. Microbiol. (1990) [Pubmed]
  15. Nucleocapsid formation and/or subsequent conformational change of rabies virus nucleoprotein (N) is a prerequisite step for acquiring the phosphatase-sensitive epitope of monoclonal antibody 5-2-26. Kawai, A., Toriumi, H., Tochikura, T.S., Takahashi, T., Honda, Y., Morimoto, K. Virology (1999) [Pubmed]
  16. Characterization of rabies virus nucleocapsids and recombinant nucleocapsid-like structures. Iseni, F., Barge, A., Baudin, F., Blondel, D., Ruigrok, R.W. J. Gen. Virol. (1998) [Pubmed]
  17. Use of anti-glycoprotein monoclonal antibodies to characterize rabies virus in formalin-fixed tissues. Warner, C., Fekadu, M., Whitfield, S., Shaddock, J. J. Virol. Methods (1999) [Pubmed]
  18. Antigenic characterisation of virus isolates from vaccinated dogs dying of rabies. Aghomo, H.O., Rupprecht, C.E. Tropical animal health and production. (1990) [Pubmed]
  19. The apparent infection of NA-C1300 cell cultures by nucleocapsid material of the Canadian Arctic strain of rabies virus. Webster, W.A., Charlton, K.M. Can. J. Microbiol. (1989) [Pubmed]
  20. Antigenic variants of rabies virus. Schneider, L.G. Comp. Immunol. Microbiol. Infect. Dis. (1982) [Pubmed]
  21. Neurotropism of rabies virus. An in vitro study. Tsiang, H., Koulakoff, A., Bizzini, B., Berwald-Netter, Y. J. Neuropathol. Exp. Neurol. (1983) [Pubmed]
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