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Gene Review

MARCO  -  macrophage receptor with collagenous...

Homo sapiens

Synonyms: Macrophage receptor MARCO, Macrophage receptor with collagenous structure, SCARA2, Scavenger receptor class A member 2
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Disease relevance of MARCO


High impact information on MARCO

  • Transfection of COS cells with MARCO cDNA conferred mAb-inhibitable TiO2 binding [5].
  • Marco Baggiolini and Clemens Dahinden discuss the involvement of CC chemokines in the recruitment and activation of the main effector cells of allergic inflammation [6].
  • The purpose of this study was to isolate which SRs (macrophage receptor with collagenous structure (MARCO), CD204, or CD36) were involved using a variety of SR single and double null mice [4].
  • Similar to the results with C57BL/6 AM, MARCO was involved with silica-induced cell death in the 129/SvJ strain [4].
  • Transfection of Chinese hamster ovary cells with human MARCO supported these conclusions, as silica particles bound to and initiated apoptosis in the MARCO-transfected cells [4].

Chemical compound and disease context of MARCO

  • A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO [7].

Biological context of MARCO

  • Although the transfection experiments with transmembrane MARCO variants have indicated a crucial role for this domain in bacterial binding, the monomeric domain exhibited low, barely detectable bacteria-binding activity [1].
  • The objective of this study was to test the expression of 3 macrophage scavenger receptors (SRs) that are responsible for innate immunity against gram-negative bacteria: SR class A type I (SR-AI), SR-AII, and the macrophage receptor with collagenous structure (MARCO) [2].
  • BACKGROUND: Phagocytosis of unopsonized pollutant particles by alveolar macrophages (AM) occurs via the macrophage receptor with collagenous structure (MARCO) [8].
  • The results indicate that expression of MARCO has a direct effect in generating the phenotype of activated macrophages necessary for the trapping and removal of pathogens and other foreign substances [9].
  • In this study, we show that ectopic expression of MARCO in cell lines such as Chinese hamster ovary, HeLa, NIH3T3, and 293 induces dramatic cell shape changes [9].

Anatomical context of MARCO


Associations of MARCO with chemical compounds

  • However, the human MARCO polypeptide chain lacked the intracellular cysteine present in mouse, as well as two extracellular cysteines that form interchain disulfide bonds in the murine protein [3].
  • Using the surface plasmon resonance technique, we show here that a recombinant, soluble form of MARCO, sMARCO, binds the major Gram-negative and -positive bacterial surface components, lipopolysaccharide and lipoteichoic acid [7].
  • Yet, the interaction of these two polyanions with sMARCO is of much lower affinity than that of polyinosinic acid, a polyanionic inhibitor of bacterial binding to MARCO [7].
  • Phosphorothioate (PS)-linked CpG-ODN stimulated IL-12 and NO production in wild-type but not in MARCO-deficient, thioglycollate-elicited peritoneal macrophages [11].
  • The MARCO (macrophage receptor with collagenous structure) glycoprotein belongs to the scavenger receptor type family of pattern-recognition molecules produced by a subset of marginal zone macrophages in the spleen [12].

Other interactions of MARCO

  • Our findings suggest that UGRP1-MARCO is a ligand-receptor pair that is probably involved in inflammation and pathogen clearance in the lung [13].
  • In marked contrast, MARCO expression was high in almost all samples of RA SFMC [2].
  • Cytocentrifuged AM were dual immunostained with monoclonal antibodies to the panmacrophage marker CD68, and either MARCO or an appropriate isotypic control [8].
  • The ability of MARCO to bind CpG-ODNs and conversely, to costimulate IL-12 and NO production upon specific ligation with immobilized mAb is consistent with MARCO being a signaling receptor for CpG-ODNs, costimulating TLR9-mediated NO and IL-12 production in macrophages [11].
  • According to Kaplan-Meier estimates, high EPHA1, and low SMAD1 and MARCO expression were associated with better progression-free survival (PFS) [14].

Analytical, diagnostic and therapeutic context of MARCO

  • Using COS transfectants with different truncated forms of MARCO, allowed epitope mapping for the PLK-1 Ab to MARCO domain V between amino acid residues 420 and 431 [10].
  • A polyclonal antibody to human MARCO identified the expected approximately 70-kD band on Western blots of lysates of normal bronchoalveolar lavage (BAL) cells (>90% AMs) and showed strong immunolabeling of human AMs in BAL cytocentrifuge preparations and within lung tissue specimens [5].
  • Radiation hybrid mapping localized hMARCO to chromosome 2q14 [15].
  • Re: Francesco Porpiglia, Carlo Terrone, Julien Renard, Susanna Grande, Francesca Musso, Marco Cossu, Francesca Vacca and Roberto Mario Scarpa. Transcapsular Adenomectomy (Millin): A Comparative Study, Extraperitoneal Laparoscopy versus Open Surgery. Eur Urol 2006;49:120-6 [16].
  • The electrophysiological parameters (Marco EMG amplitudes and fiber density) revealed evidence of reinnervation, indicating preceeding denervation and therefore loss of motor units [17].


  1. Characterization of recombinant soluble macrophage scavenger receptor MARCO. Sankala, M., Brännström, A., Schulthess, T., Bergmann, U., Morgunova, E., Engel, J., Tryggvason, K., Pikkarainen, T. J. Biol. Chem. (2002) [Pubmed]
  2. Expression of host defense scavenger receptors in spondylarthropathy. Seta, N., Granfors, K., Sahly, H., Kuipers, J.G., Song, Y.W., Baeten, D., Veys, E.M., Maksymowych, W., Märker-Hermann, E., Gu, J., Huang, F., Kirveskari, J., Yu, D.T. Arthritis Rheum. (2001) [Pubmed]
  3. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. Elomaa, O., Sankala, M., Pikkarainen, T., Bergmann, U., Tuuttila, A., Raatikainen-Ahokas, A., Sariola, H., Tryggvason, K. J. Biol. Chem. (1998) [Pubmed]
  4. MARCO Mediates Silica Uptake and Toxicity in Alveolar Macrophages from C57BL/6 Mice. Hamilton, R.F., Thakur, S.A., Mayfair, J.K., Holian, A. J. Biol. Chem. (2006) [Pubmed]
  5. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. Palecanda, A., Paulauskis, J., Al-Mutairi, E., Imrich, A., Qin, G., Suzuki, H., Kodama, T., Tryggvason, K., Koziel, H., Kobzik, L. J. Exp. Med. (1999) [Pubmed]
  6. CC chemokines in allergic inflammation. Baggiolini, M., Dahinden, C.A. Immunol. Today (1994) [Pubmed]
  7. A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO. Chen, Y., Sankala, M., Ojala, J.R., Sun, Y., Tuuttila, A., Isenman, D.E., Tryggvason, K., Pikkarainen, T. J. Biol. Chem. (2006) [Pubmed]
  8. MARCO expression on pediatric alveolar macrophages. Bunn, H.J., Kobzik, L., Grigg, J. Cytometry. Part B, Clinical cytometry. (2004) [Pubmed]
  9. Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes. Pikkarainen, T., Brännström, A., Tryggvason, K. J. Biol. Chem. (1999) [Pubmed]
  10. MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. Arredouani, M.S., Palecanda, A., Koziel, H., Huang, Y.C., Imrich, A., Sulahian, T.H., Ning, Y.Y., Yang, Z., Pikkarainen, T., Sankala, M., Vargas, S.O., Takeya, M., Tryggvason, K., Kobzik, L. J. Immunol. (2005) [Pubmed]
  11. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J??zefowski, S., Sulahian, T.H., Arredouani, M., Kobzik, L. J. Leukoc. Biol. (2006) [Pubmed]
  12. Species-specific restriction of cell surface expression of mouse MARCO glycoprotein in murine cell lines. Kvell, K., Czömpöly, T., Pikkarainen, T., Balogh, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. Bin, L.H., Nielson, L.D., Liu, X., Mason, R.J., Shu, H.B. J. Immunol. (2003) [Pubmed]
  14. Differential gene expression in non-malignant tumour microenvironment is associated with outcome in follicular lymphoma patients treated with rituximab and CHOP. Harjunpää, A., Taskinen, M., Nykter, M., Karjalainen-Lindsberg, M.L., Nyman, H., Monni, O., Hemmer, S., Yli-Harja, O., Hautaniemi, S., Meri, S., Leppä, S. Br. J. Haematol. (2006) [Pubmed]
  15. Molecular characterization of a human scavenger receptor, human MARCO. Elshourbagy, N.A., Li, X., Terrett, J., Vanhorn, S., Gross, M.S., Adamou, J.E., Anderson, K.M., Webb, C.L., Lysko, P.G. Eur. J. Biochem. (2000) [Pubmed]
  16. Re: Francesco Porpiglia, Carlo Terrone, Julien Renard, Susanna Grande, Francesca Musso, Marco Cossu, Francesca Vacca and Roberto Mario Scarpa. Transcapsular Adenomectomy (Millin): A Comparative Study, Extraperitoneal Laparoscopy versus Open Surgery. Eur Urol 2006;49:120-6. Gibbon, N.O. Eur. Urol. (2007) [Pubmed]
  17. The quadriceps femoris muscle in 20-70-year-old subjects: relationship between knee extension torque, electrophysiological parameters, and muscle fiber characteristics. Stålberg, E., Borges, O., Ericsson, M., Essén-Gustavsson, B., Fawcett, P.R., Nordesjö, L.O., Nordgren, B., Uhlin, R. Muscle Nerve (1989) [Pubmed]
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