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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Urachus


High impact information on Urachus

  • The tumor had a characteristic location along the expected midline course of the urachus directly behind the anterior abdominal wall [2].
  • Although the urachus and urethra were ligated, meperidine is found in samples of amniotic and allantoic fluid, indicating that the drug can diffuse across the placental membranes from the mother into these fluids [3].
  • Elevated serum AFP can also occur with tumors of the gastrointestinal tract, pancreas, lung, kidney, and urachus [4].
  • After being separated from its mother, the animal was sedated with i.m. butorphanol and anesthetized with isoflurane in oxygen for surgical correction of the patent urachus [5].
  • These results demonstrate that the urachus can develop spontaneous contractile activity and responds to alterations in O2, a beta-agonist, and PGF2 alpha.(ABSTRACT TRUNCATED AT 250 WORDS)[6]

Associations of Urachus with chemical compounds

  • In Krebs bicarbonate buffer (pH 7.4 bubbled with 95% O2-5% CO2 at 37 degrees C) the urachus spontaneously developed a prolonged elevated resting tension (RT, 1.1-1.5 g) [6].
  • The urachus showed a significant increase in RT (0.74 +/- 0.08 to 1.71 +/- 0.28 g, P less than 0.01) when prostaglandin F2 alpha (PGF2 alpha; 10 microM) was added to the low-O2 buffer [6].


  1. Prognostic factors for long-term renal function in boys with the prune-belly syndrome. Noh, P.H., Cooper, C.S., Winkler, A.C., Zderic, S.A., Snyder, H.M., Canning, D.A. J. Urol. (1999) [Pubmed]
  2. Urachal carcinoma: CT findings. Brick, S.H., Friedman, A.C., Pollack, H.M., Fishman, E.K., Radecki, P.D., Siegelbaum, M.H., Mitchell, D.G., Lev-Toaff, A.S., Caroline, D.F. Radiology. (1988) [Pubmed]
  3. Urinary excretion of meperidine by the fetal lamb. Szeto, H.H., Kaiko, R.F., Clapp, J.F., Larrow, R.W., Mann, L.I., Inturrisi, C.E. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  4. Gallbladder carcinoma producing alpha-fetoprotein. St Laurent, M., Esterl, R.M., Halff, G.A., Speeg, K.V. J. Clin. Gastroenterol. (1999) [Pubmed]
  5. Diagnosis and management of a patent urachus in a white rhinoceros calf (Ceratotherium simum simum). Langan, J., Ramsay, E., Schumacher, J., Chism, T., Adair, S. J. Zoo Wildl. Med. (2001) [Pubmed]
  6. Ovine fetal urachus--physiological and hormonal control of its contractile activity. Lye, S.J., Freitag, C.L., Challis, J.R. Am. J. Physiol. (1988) [Pubmed]
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