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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Group Structure

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Disease relevance of Group Structure

  • The importance of carotenoid end group structure and ring-to-chain conformation around the C-6-C-7 torsion angle of the carotenoid molecule in binding and complex reassembly is discussed [1].
  • The restoration of normal plantar flexor group structure and function indicates that the degree of recovery attained by MGN grafts, although not complete, was sufficient to ensure that the performance of the total muscle group was not compromised [2].

High impact information on Group Structure

  • Studies on synthetic lysophosphatides showed that polar head group structure, acyl chain length, and stereochemical configuration are important determinants for attractant activity [3].
  • We recently identified ABO(H) blood group structures in Asn-linked sugar chains of human von Willebrand factor (vWF) purified from factor VIII concentrates (J Biol Chem 267:8723, 1992) [4].
  • Enzymatic characterization of the protein expressed by this cDNA demonstrates that it encodes a beta 1,4-N-acetylgalactosamine transferase activity that can add to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form the nonreducing terminal tetrasaccharide Sda blood group structure [5].
  • These results indicate that the glucose transport system of LM cells is sensitive to polar head group structure of the phospholipids [6].
  • Expression of the core blood group structures sialosyl Tn (STn) and Tn is regarded as a colorectal cancer-specific change reflecting truncated synthesis of the oligosaccharide component of goblet cell mucin [7].

Chemical compound and disease context of Group Structure

  • Role of head group structure in the phase behavior of amino phospholipids. 2. Lamellar and nonlamellar phases of unsaturated phosphatidylethanolamine analogues [8].
  • That is, any water or choline group structure may be evanescent on this time scale [9].
  • A nonmicellizable quaternary ammonium salt, the tetrabutylammonium bromide (TBABr), which has a head group structure very similar to pOOTBABr, not only induces a remarkable superactivation, at a concentration 80-fold higher than pOOTBABr, but also allows the enzyme to retain a high residual activity for long periods of time [10].
  • Zinc pyrithione also exhibited an interaction with the ammonium tail of the head group structures [11].
  • An isomeric structure with an internal alphaGalNAc linkage was also recognized but less efficiently. mAb VK-9 did not react with many related structures, such as galactosylgloboside, globoside, H type 1, H type 2 blood group structures or fucosyl-gangliotetraosyl ceramide, but did react weakly with globo A ceramide [12].

Gene context of Group Structure

  • Increasing chain length corresponds to a temperature effect, which was quantified for different lipids, depending on the head group structure using isotherm (two-dimensional systems) and DSC (three-dimensional systems) measurements [13].
  • Seven of 14 lesions lacked ABH antigens, the loss of blood group structures could not however be correlated with any specific histological features and was not limited to the loss of A and B substances [14].
  • The results indicate that this antibody reacts with the difucosylated blood group structures ALeb and ALey: (formula; see text) This antibody differs from the previously described anti-EGF receptor antibody [15].
  • As a consequence of these revisions it is possible to conceptualize preoedipal organizations of group structure in addition to the oedipal paradigm proposed by Freud [16].
  • To understand the mechanism of annexin V-membrane interactions, we measured the interaction of human recombinant annexin V with phospholipid monolayers with differing head group and acyl group structures [17].


  1. The binding of Xanthophylls to the bulk light-harvesting complex of photosystem II of higher plants. A specific requirement for carotenoids with a 3-hydroxy-beta-end group. Phillip, D., Hobe, S., Paulsen, H., Molnar, P., Hashimoto, H., Young, A.J. J. Biol. Chem. (2002) [Pubmed]
  2. Recovery of medial gastrocnemius muscle grafts in rats: implications for the plantar flexor group. Miller, S.W., Hassett, C.A., White, T.P., Faulkner, J.A. J. Appl. Physiol. (1994) [Pubmed]
  3. Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine. Hoffman, R.D., Kligerman, M., Sundt, T.M., Anderson, N.D., Shin, H.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  4. Human plasma alpha 2-macroglobulin and von Willebrand factor possess covalently linked ABO(H) blood group antigens in subjects with corresponding ABO phenotype. Matsui, T., Fujimura, Y., Nishida, S., Titani, K. Blood (1993) [Pubmed]
  5. Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen. Smith, P.L., Lowe, J.B. J. Biol. Chem. (1994) [Pubmed]
  6. Enhancement of the reconstituted glucose transport activity from LM cells by phosphatidylethanolamine. Baldassare, J.J. J. Biol. Chem. (1983) [Pubmed]
  7. Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium. Jass, J.R., Allison, L.J., Edgar, S.G. J. Pathol. (1995) [Pubmed]
  8. Role of head group structure in the phase behavior of amino phospholipids. 2. Lamellar and nonlamellar phases of unsaturated phosphatidylethanolamine analogues. Brown, P.M., Steers, J., Hui, S.W., Yeagle, P.L., Silvius, J.R. Biochemistry (1986) [Pubmed]
  9. Kinetics of charge transfer at the lipid bilayer-water interface on the nanosecond time scale. Woodle, M., Zhang, J.W., Mauzerall, D. Biophys. J. (1987) [Pubmed]
  10. Activation and stabilization of alpha-chymotrypsin by cationic additives. Spreti, N., Di Profio, P., Marte, L., Bufali, S., Brinchi, L., Savelli, G. Eur. J. Biochem. (2001) [Pubmed]
  11. Pyrithione biocide interactions with bacterial phospholipid head groups. Dinning, A.J., Al-Adham, I.S., Austin, P., Charlton, M., Collier, P.J. J. Appl. Microbiol. (1998) [Pubmed]
  12. Characterization of a mouse monoclonal IgG3 antibody to the tumor-associated globo H structure produced by immunization with a synthetic glycoconjugate. Kudryashov, V., Ragupathi, G., Kim, I.J., Breimer, M.E., Danishefsky, S.J., Livingston, P.O., Lloyd, K.O. Glycoconj. J. (1998) [Pubmed]
  13. Generic phase behavior of branched-chain phospholipid monolayers. Bringezu, F., Dobner, B., Brezesinski, G. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  14. The expression of ABH and Y blood group antigens in benign and malignant breast tissue: the preservation of the H and Y antigens in malignant epithelium. Vowden, P., Lowe, A.D., Lennox, E.S., Bleehen, N.M. Br. J. Cancer (1986) [Pubmed]
  15. Monoclonal antibody (EGR/G49) reactive with the epidermal growth factor receptor of A431 cells recognizes the blood group ALeb and ALey structures. Gooi, H.C., Picard, J.K., Hounsell, E.F., Gregoriou, M., Rees, A.R., Feizi, T. Mol. Immunol. (1985) [Pubmed]
  16. Group psychology and the structural theory: a revised psychoanalytic model of group psychology. Saravay, S.M. Journal of the American Psychoanalytic Association. (1975) [Pubmed]
  17. Interactions of annexin V with phospholipid monolayers. Mukhopadhyay, S., Cho, W. Biochim. Biophys. Acta (1996) [Pubmed]
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