Disease relevance of CC2D1A

• 150 years of Sigmund Freud: what would Freud have said about the obesity epidemic [1]?
• Freud and migraine: the beginning of a psychodynamically oriented view of headache a hundred years ago [2].
• The controversial history of functional hemianopsia is reviewed from Briquet's 1859 monograph on 430 cases of hysteria, through the 19th century works of Charcot, Freud, and Janet, and the observations of Fox and Wilbrand and Saenger in the early 20th century [3].
• Sigmund Freud was the first to write about cerebral palsy as a nosographic category, uniting various infantile motor deficits of brain origin [4].
• Sigmund Freud: smoking habit, oral cancer and euthanasia [5].

Psychiatry related information on CC2D1A

• Novel autosomal genes that cause mental retardation have been identified recently including CC2D1A identified by homozygosity mapping [6].
• Hysteria, as classically defined (before Freud), is a chronic polysymptomatic illness chiefly affecting women [7].
• Alfred Adler's significance for the concept of narcissism is presented with reference to four aspects: 1) Adler's theory of masculine protest was evidently a factor influencing Freud to turn toward the phenomenon of narcissism [8].
• Although Meyer and Freud believed that the seeds of mental health are sown in childhood, systematic research has proved difficult and disappointing, and theory has remained intensely controversial [9].
• The author traces the historical background of brief psychotherapy, focusing on the contributions of Freud, Ferenczi, Rank, and Alexander and French, and then presents a synthesis of contemporary views [10].

High impact information on CC2D1A

• The early Freud of the seduction theory of hysteria did inspire the recovered memory fiasco [11].
• Freud and homosexuality [12].
• We will see that research questions and strategies in the current study of disease and therapeutics have not fundamentally shifted from Freud and Meyer to modern molecular neurobiology [13].
• Generalized, persistent, and free-floating anxiety was first described by Freud in 1894, although the diagnostic term generalized anxiety disorder (GAD) was not included in classification systems until 1980 (Diagnostic and Statistical Manual for Mental Disorders, Third Edition [DSM-III]) [14].
• The psychopathology, as formulated by Freud and others, is also described [15].

Chemical compound and disease context of CC2D1A

• The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation [16].
• Cocaine is derived from the leaves of Erythroxylon coca, a shrub native to South America. In the late 1800s, Sigmund Freud popularized the drug in Europe. He used cocaine to treat depression, asthma, cachexia, and for overcoming morphine addiction [17].

Biological context of CC2D1A

• We have recently identified a protein-truncating mutation, G408fsX437, in the gene CC2D1A on chromosome 19p13.12 in nine consanguineous Israeli Arab families with severe autosomal recessive NSMR, and have developed a comprehensive prevention program among the at-risk population in the village [18].
• Long-term potentiation and memory processes in the psychological works of Sigmund Freud and in the formation of neuropsychiatric symptoms [19].
• Fridtiof Nansen (1861-1930), an arctic explorer and a cofounder of the neuron doctrine, knew Sigmund Freud (1856-1939), a neuroscientist and the founder of psychoanalysis, as well as Harvey Cushing (1869-1939), the father of modern neurosurgery [20].
• Freud made several significant contributions to research in neuroanatomy and clinical neurology that were overshadowed by his later accomplishments [21].
• Genetics has been associated with psychoanalytic theory since the earliest writings of Freud [22].

Anatomical context of CC2D1A

• Fluoride inhibits photohemolysis induced by chloroaluminum phthalocyanine tetrasulfonate (AlPcS4) when it is added to dye-loaded human erythrocytes prior to light exposure (E. Ben-Hur, A. Freud, A. Canfi, and A. Livne, Int. J. Radiat. Biol. 59, 797-806, 1991) [23].
• Concerning the biology of the cell nucleus, Freud appears to have been the first author who documented movements of nucleoli in nerve cells, a phenomenon presently referred to as nuclear rotation [24].
• Through his histological studies Freud provided coherent evidence suggesting that the protoplasm consists of a contractile fibrillary network, the present-day cytoskeleton; he was one of the original founders of the fibrillary theory on the structure of the protoplasm [24].
• In the summers of 1879 and 1881, while Freud was a research student in Ernst von Brücke's laboratory at the Institute of Physiology at the University of Vienna, he carried out an important though seldom remembered investigation on the internal structure of nerve fibers and cells [25].
• Sigmund Freud and the VIIIth Cranial Nerve [26].

Associations of CC2D1A with chemical compounds

• CC2D1A is a member of a previously uncharacterised gene family that carries two conserved motifs, a C2 domain and a DM14 domain [16].
• Presentation of the C. Anderson Aldrich award to Anna Freud [27].
• Freud, Prozac, and the human condition [28].
• Freud first saw this in America's attitude toward the use of cocaine [29].
• Words and images in H.D.'s Tribute to Freud [30].

Other interactions of CC2D1A

• Neurological stamp. Sigmund Freud (1856-1939) [31].
• This per se can help us to understand how a 'certain image' of Freud was created in Great Britain during those years and the reasons for its authoritative persistence [32].
• Ernest Jones, in particular, an analysand of Ferenczi and fellow member of the Secret Committee founded by Freud before World War I, seriously attacked Ferenczi [33].
• The paper investigates the patient's view of how such an inhibition was cured in a brief analytic treatment of the American poet Hilda Doolittle conducted by Freud in 1933-34 [34].
• Freud, Irma, Martha: sex and marriage in the "Dream of Irma's injection" [35].

Analytical, diagnostic and therapeutic context of CC2D1A

• CC2D1A is a putative signal transducer participating in positive regulation of I-kappaB kinase/NFkappaB cascade [16].
• OBJECTIVE: This paper describes a chart review of 763 cases of child psychoanalysis and psychotherapy at the Anna Freud Centre, and illustrates its usefulness by examining predictors of treatment outcome in children with disruptive disorders [36].
• Lacan's analysis of Descartes' search for ontological certainty draws him, in Freud, to the ontological implications of castration anxiety, disavowal, and splitting of the ego [37].
• Egyptian artefacts were, for Freud, links to the prehistory of the Jewish people; they also represent an era when maternal deities found their proper place in man's pantheon--an echo of Freud's prehistoric past [38].
• 'My bad diagnostic error': once more about Freud and Emmy v. N. (Fanny Moser) [39].

References