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Chemical Compound Review

BC-J     zinc 1-oxidopyridine-6-thiolate

Synonyms: Biocut ZP, Finecide ZPT, Hokucide ZPT, Niccanon SKT, Tomicide Z 50, ...
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Disease relevance of SQ 2113


Psychiatry related information on SQ 2113


High impact information on SQ 2113


Chemical compound and disease context of SQ 2113


Biological context of SQ 2113


Anatomical context of SQ 2113

  • Zinc pyrithione, however, was assayed in the cytosol of both bacteria and was found in the cell envelope of Ps. aeruginosa [19].
  • Each of four antidandruff shampoos, containing zinc pyrithione, was statistically significantly more potent at blocking spontaneous contractions of rabbit isolated ileum than was any of four adult shampoos which in turn were each significantly more potent that any of four baby shampoos tested [20].
  • Results indicated that zinc pyrithione produced the highest inhibition of cell growth when two cell lines were treated in the two doses tested [21].
  • Zinc pyrithione introduced into cultures of rapidly proliferating NCTC 2544 human skin epithelial cells and normal human skin fibroblasts had a rapid cytotoxic effect even at very low concentrations (0.1-0.5 microgram/ml); there was no dose-dependent suppression of cell proliferation and no apparent interference with mitosis [22].
  • The mutagenic potential of zinc pyrithione (Znpt) was evaluated in vitro in the Salmonella/mammalian microsome plate incorporation mutagenicity (Ames) assay and the CHO/HGPRT gene mutation assay [23].

Associations of SQ 2113 with other chemical compounds


Gene context of SQ 2113

  • Zinc pyrithione induces apoptosis and increases expression of Bim [28].
  • Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay [23].
  • The relationship between environmental factors, community composition and the sensitivity of pelagic phytoplankton to the antifouling agents zinc pyrithione (ZPT) and copper pyrithione (CPT) was studied using phytoplankton communities collected from March until August 2001 in Roskilde fjord, Denmark [29].

Analytical, diagnostic and therapeutic context of SQ 2113


  1. Zinc pyrithione and peripheral neuritis. Beck, J.E. Lancet (1978) [Pubmed]
  2. Ultrastructural study of zinc pyridinethione-induced peripheral neuropathy. Sahenk, Z., Mendell, J.R. J. Neuropathol. Exp. Neurol. (1979) [Pubmed]
  3. The use of 0.25% zinc pyrithione spray does not enhance the efficacy of clobetasol propionate 0.05% foam in the treatment of psoriasis. Housman, T.S., Keil, K.A., Mellen, B.G., McCarty, M.A., Fleischer, A.B., Feldman, S.R. J. Am. Acad. Dermatol. (2003) [Pubmed]
  4. Allergic contact dermatitis from zinc pyrithione. Pereira, F., Fernandes, C., Dias, M., Lacerda, M.H. Contact Derm. (1995) [Pubmed]
  5. Pyrithione biocide interactions with bacterial phospholipid head groups. Dinning, A.J., Al-Adham, I.S., Austin, P., Charlton, M., Collier, P.J. J. Appl. Microbiol. (1998) [Pubmed]
  6. Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry. Bones, J., Thomas, K.V., Paull, B. Journal of chromatography. A. (2006) [Pubmed]
  7. Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects. Guthery, E., Seal, L.A., Anderson, E.L. American journal of infection control. (2005) [Pubmed]
  8. ZPT-related distal axonopathy: behavioral and electrophysiologic correlates in rats. Ross, J.F., Lawhorn, G.T. Neurotoxicology and teratology. (1990) [Pubmed]
  9. Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around. Sahenk, Z., Mendell, J.R. Brain Res. (1980) [Pubmed]
  10. Ecological effects of the insecticide imidacloprid and a pollutant from antidandruff shampoo in experimental rice fields. Sanchez-Bayo, F., Goka, K. Environ. Toxicol. Chem. (2006) [Pubmed]
  11. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Piérard-Franchimont, C., Goffin, V., Decroix, J., Piérard, G.E. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
  12. Influence of light in acute toxicity bioassays of imidacloprid and zinc pyrithione to zooplankton crustaceans. Sánchez-Bayo, F., Goka, K. Aquat. Toxicol. (2006) [Pubmed]
  13. Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment. Lorette, G., Ermosilla, V. European journal of dermatology : EJD (2006) [Pubmed]
  14. A percutaneous teratology study of zinc pyrithione in rabbits. Nolen, G.A., Patrick, L.F., Dierckman, T.A. Toxicol. Appl. Pharmacol. (1975) [Pubmed]
  15. Percutaneous absorption of zinc pyridinethione in monkeys. Gibson, W.B., Calvin, G. Toxicol. Appl. Pharmacol. (1978) [Pubmed]
  16. Environmental fate of the antifouling compound zinc pyrithione in seawater. Grunnet, K.S., Dahllöf, I. Environ. Toxicol. Chem. (2005) [Pubmed]
  17. The effect and mode of action of zinc pyrithione on cell growth. II. In vivo studies. Gibson, W.T., Hardy, W.S., Groom, M.H. Food Chem. Toxicol. (1985) [Pubmed]
  18. Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions. Pia Rigobello, M., Messori, L., Marcon, G., Agostina Cinellu, M., Bragadin, M., Folda, A., Scutari, G., Bindoli, A. J. Inorg. Biochem. (2004) [Pubmed]
  19. A novel assay for the distribution of pyrithione biocides in bacterial cells. Dinning, A.J., al-Adham, I.S., Austin, P., Collier, P.J. Lett. Appl. Microbiol. (1998) [Pubmed]
  20. The comparative toxic effects of proprietary antidandruff, adult and baby shampoos on rabbit ileum. Muir, C.K. Toxicol. Lett. (1983) [Pubmed]
  21. Toxicity of potential irritants in mammalian cells in vitro. Santa María, A., Pozuelo, J.M., López, A., Sanz, F. Ecotoxicol. Environ. Saf. (1996) [Pubmed]
  22. Acute toxicity of Zinc pyrithione to human skin cells in vitro. Priestley, G.C., Brown, J.C. Acta Derm. Venereol. (1980) [Pubmed]
  23. Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay. Skoulis, N.P., Barbee, S.J., Jacobson-Kram, D., Putman, D.L., San, R.H. Journal of applied toxicology : JAT. (1993) [Pubmed]
  24. Unexpected effects of zinc pyrithione and imidacloprid on Japanese medaka fish (Oryzias latipes). Sánchez-Bayo, F., Goka, K. Aquat. Toxicol. (2005) [Pubmed]
  25. Acute toxicity of pyrithione antifouling biocides and joint toxicity with copper to red sea bream (Pagrus major) and toy shrimp (Heptacarpus futilirostris). Mochida, K., Ito, K., Harino, H., Kakuno, A., Fujii, K. Environ. Toxicol. Chem. (2006) [Pubmed]
  26. The inhibitory effect of zinc pyrithione on the epidermal proliferation of animal skins. Imokawa, G., Okamoto, K. Acta Derm. Venereol. (1982) [Pubmed]
  27. In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains. Roques, C., Brousse, S., Panizzutti, C. Mycopathologia (2006) [Pubmed]
  28. Zinc pyrithione induces apoptosis and increases expression of Bim. Mann, J.J., Fraker, P.J. Apoptosis (2005) [Pubmed]
  29. Seasonal variations in the effect of zinc pyrithione and copper pyrithione on pelagic phytoplankton communities. Maraldo, K., Dahllöf, I. Aquat. Toxicol. (2004) [Pubmed]
  30. Determination of zinc pyrithione in cosmetic products by high-performance liquid chromatography with pre-labelling. Kondoh, Y., Takano, S. J. Chromatogr. (1987) [Pubmed]
  31. Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo. Warner, R.R., Schwartz, J.R., Boissy, Y., Dawson, T.L. J. Am. Acad. Dermatol. (2001) [Pubmed]
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