Disease relevance of Onchocerciasis, Ocular

• CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness) [1].
• Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness) [2].
• The risk of optic atrophy following suramin treatment of ocular onchocerciasis [3].
• The impact of 10-11 years of successful vector control on ocular onchocerciasis was evaluated in the population of 13 villages in the central part of the Onchocerciasis Control Programme area [4].

High impact information on Onchocerciasis, Ocular

• Further studies on the treatment of ocular onchocerciasis with diethylcarbamazine and suramin [5].
• Evaluation of microfilaricidal effects in the cornea from topically applied drugs in ocular onchocerciasis: Trials with levamisole and mebendazole [6].
• Effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis, and the possibilities of improved therapy from continuous non-pulsed delivery [7].
• We illustrate the process of validation by presenting a (re)analysis of fly-feeding experiments carried out by the Onchocerciasis (river blindness) Control Programme (OCP/WHO) in West Africa, with the objective to validate ONCHOSIM, an onchocerciasis transmission model [8].
• River blindness: a role for parasite retinoid-binding proteins in the generation of pathology [9]?

Chemical compound and disease context of Onchocerciasis, Ocular

• Diethylcarbamazine was given as eye drops in varying concentrations in a half-log dilution series from 1.0 to 0.0001% to patients with ocular onchocerciasis [7].
• A single 10-14 day course of diethylcarbamazine (DEC) was given under betamethazone cover to 18 patients (Group A) with ocular onchocerciasis, and the effects were studied in detail over 1-2 years [10].

Gene context of Onchocerciasis, Ocular

• The community pattern of ocular onchocerciasis is described for 11 villages from the forest area in Côte d'Ivoire where S. sanctipauli is the princial vector [11].

References