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MeSH Review

Neurofibroma, Plexiform

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Disease relevance of Neurofibroma, Plexiform


High impact information on Neurofibroma, Plexiform


Chemical compound and disease context of Neurofibroma, Plexiform


Biological context of Neurofibroma, Plexiform


Anatomical context of Neurofibroma, Plexiform

  • The second patient, a 45 year old female recognised her problem at the age of 39 years, did not quite satisfy the NIH diagnostic criteria for NF 1 and had diffuse plexiform neurofibroma involving both lower limbs and buttocks almost symmetrically, a finding which has not previously been described to the best of our knowledge [16].

Gene context of Neurofibroma, Plexiform


Analytical, diagnostic and therapeutic context of Neurofibroma, Plexiform


  1. An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. Easton, D.F., Ponder, M.A., Huson, S.M., Ponder, B.A. Am. J. Hum. Genet. (1993) [Pubmed]
  2. Subclassification of nerve sheath tumors by gene expression profiling. Holtkamp, N., Reuss, D.E., Atallah, I., Kuban, R.J., Hartmann, C., Mautner, V.F., Frahm, S., Friedrich, R.E., Algermissen, B., Pham, V.A., Prietz, S., Rosenbaum, T., Estevez-Schwarz, L., von Deimling, A. Brain Pathol. (2004) [Pubmed]
  3. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. Perry, A., Kunz, S.N., Fuller, C.E., Banerjee, R., Marley, E.F., Liapis, H., Watson, M.A., Gutmann, D.H. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  4. Culture of cytogenetically abnormal schwann cells from benign and malignant NF1 tumors. Wallace, M.R., Rasmussen, S.A., Lim, I.T., Gray, B.A., Zori, R.T., Muir, D. Genes Chromosomes Cancer (2000) [Pubmed]
  5. Contiguous conventional and plexiform schwannomas. Report of two cases. White, J.B., Scheithauer, B.W., Amrami, K.K., Babovic-Vuksanovic, D., Spinner, R.J. J. Neurosurg. (2006) [Pubmed]
  6. A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Cappione, A.J., French, B.L., Skuse, G.R. Am. J. Hum. Genet. (1997) [Pubmed]
  7. Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells. Muir, D., Neubauer, D., Lim, I.T., Yachnis, A.T., Wallace, M.R. Am. J. Pathol. (2001) [Pubmed]
  8. Delayed rectifier K currents in NF1 Schwann cells. Pharmacological block inhibits proliferation. Fieber, L.A., González, D.M., Wallace, M.R., Muir, D. Neurobiol. Dis. (2003) [Pubmed]
  9. Pigment cell-related manifestations in neurofibromatosis type 1: an overview. De Schepper, S., Boucneau, J., Lambert, J., Messiaen, L., Naeyaert, J.M. Pigment Cell Res. (2005) [Pubmed]
  10. CO2-laser in the removal of a plexiform neurofibroma from the eyelid. Lapid-Gortzak, R., Lapid, O., Monos, T., Lifshitz, T. Ophthalmic surgery and lasers. (2000) [Pubmed]
  11. Laryngeal neurofibroma: case report of a child. Chen, Y.C., Lee, K.S., Yang, C.C., Chang, K.C. Int. J. Pediatr. Otorhinolaryngol. (2002) [Pubmed]
  12. Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1. Gupta, A., Cohen, B.H., Ruggieri, P., Packer, R.J., Phillips, P.C. Neurology (2003) [Pubmed]
  13. Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. Widemann, B.C., Salzer, W.L., Arceci, R.J., Blaney, S.M., Fox, E., End, D., Gillespie, A., Whitcomb, P., Palumbo, J.S., Pitney, A., Jayaprakash, N., Zannikos, P., Balis, F.M. J. Clin. Oncol. (2006) [Pubmed]
  14. Identification of de novo deletions at the NF1 gene: no preferential paternal origin and phenotypic analysis of patients. Valero, M.C., Pascual-Castroviejo, I., Velasco, E., Moreno, F., Hernández-Chico, C. Hum. Genet. (1997) [Pubmed]
  15. Clonal origin of tumor cells in a plexiform neurofibroma with LOH in NF1 intron 38 and in dermal neurofibromas without LOH of the NF1 gene. Däschner, K., Assum, G., Eisenbarth, I., Krone, W., Hoffmeyer, S., Wortmann, S., Heymer, B., Kehrer-Sawatzki, H. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  16. Neurofibromatosis type 1: report of two contrasting cases. Sheikh, N., McLigeyo, S.O. East African medical journal. (2002) [Pubmed]
  17. Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression. Muir, D. Clin. Exp. Metastasis (1995) [Pubmed]
  18. Peripheral nerve sheath tumors from patients with neurofibromatosis type 1 do not have the chromosomal translocation t(X;18). Liew, M.A., Coffin, C.M., Fletcher, J.A., Hang, M.T., Tanito, K., Niimura, M., Viskochil, D. Pediatr. Dev. Pathol. (2002) [Pubmed]
  19. Tumour suppressor genes, immunology and local manifestations of neurofibromatosis phenotypes. Gerosa, P.L., Spinelli, M., Iannarelli, S., Giussani, G., Canepari, C., Fontana, A., Vai, C., Bizzozero, L. Panminerva medica. (1996) [Pubmed]
  20. Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. Peters, N., Waha, A., Wellenreuther, R., Friedrich, R.E., Mautner, V.F., Hoffmeyer, S., Lenartz, D., Schramm, J., Wiestler, O.D., von Deimling, A. Acta Neuropathol. (1999) [Pubmed]
  21. Liposuction: a less invasive surgical method of debulking plexiform neurofibromas. Babovic, S., Bite, U., Karnes, P.S., Babovic-Vuksanovic, D. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2003) [Pubmed]
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