Disease relevance of Luteoma

• While a luteoma of term pregnancy (n = 1), a benign cystadenoma (n = 2), and an endometriotic cyst (n = 1) had no detectable immunoreactive OT, the concentrations of immunoreactive OT were 20.0 ng/g in a thecoma, 1.4, 20.0, and 60.0 ng/g in preovulatory follicles (n = 3), and 41.0 and 37.0 ng/g in polycystic ovaries (n = 2) [1].
• Testosterone was detected immunohistochemically in the hilus cell hyperplasia, stromal luteoma and hyperthecosis found in the hyperandrogenic patients [2].
• OBJECTIVE: To present the maternal and female fetal virilization caused by excessive androgen secretion of pregnancy luteomas [3].

High impact information on Luteoma

• When this transgene is expressed in other strains of mice, including (C57BL/6 female symbol x CF-1 male symbol,Tg) F1 hybrids, luteomas develop even though levels of LH remain high [4].
• The effect of buserelin on inositol phosphates was evaluated after incubation of luteoma and SPO cells with [3H]myoinositol for 48 h [5].
• Again, luteoma cells did not respond to buserelin stimulation, although NaF (10 mM), an activator of G proteins coupled to phospholipase C, induced an 800% increase in inositol trisphosphate [5].
• Cyclic AMP stimulation was found in one tumor of sex cord-stromal origin, in two of epithelial origin, in two of germ cell origin, and in one tumor-like condition, pregnancy luteoma [6].
• Similarities were noted between the pregnancy luteoma cells and, as described by other authors, the luteinized granulosa and theca cells of the human corpus luteum and the cells of spontaneous mouse luteoma [7].

Chemical compound and disease context of Luteoma

• In vivo steroid studies in luteoma of pregnancy [8].
• A patient with diabetes and luteomas of the ovaries demonstrated a significant and progressive rise in the serum levels of androstenedione and testosterone during pregnancy [9].
• High correlation between prolactinemia, 125-I hLH binding and progesterone secretion by an experimental luteoma [10].
• The luteoma, serum androgen levels, and patient's condition improved after delivery [11].
• Uncommon adnexal lesions specific to pregnancy include hyperreactio luteinalis, theca lutein cysts with moles, and luteomas [12].

Biological context of Luteoma

• Diagnostic workup findings showed a female karyotype, homozygous 21-hydroxylase deficiency, and excessive testosterone exposure prenatally as a consequence of maternal pregnancy luteoma, altogether causing this unusual phenotype [13].

Anatomical context of Luteoma

• Together, these dynamic changes in the ovarian transcriptome indict various signaling pathways potentially involved in mediating the actions of LH over time and, depending on genetic background, the formation of either a luteoma or a granulosa cell tumor [4].
• GnRH mRNA was present in SPO, isolated corpora lutea from SPO and Luteoma from 1 week to 7 months of development [14].

Gene context of Luteoma

• Buserelin (GnRH analog) increased GnRH mRNA and peptide expression in SPO but not in Luteoma cells [14].
• They have been divided into two subtypes according to their cell of origin as follows: stromal luteoma, and Leydig cell tumors, and a third subtype with lineage unknown is a steroid cell tumor, not otherwise specified (NOS) [15].
• Properties of human gonadotrophins eluted from human corpus luteum and mouse luteoma LH-HCG receptors [16].

Analytical, diagnostic and therapeutic context of Luteoma

• About 112 patients with luteomas of pregnancy have been reported in the literature. the differential diagnosis includes theca lutein cysts, the oedematous ovary syndrome and luteinized forms of ovarian stromal tumours [17].

References