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Gene Review

Mtv7  -  mammary tumor virus locus 7

Mus musculus

Synonyms: Mls, Mls-1, Mls1, Mtv-10, Mtv-19, ...
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Disease relevance of Mtv7

  • Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7 [1].
  • A 1.8-kb mRNA in C57L/J and MA/MyJ lymphomas hybridized with an Mtv29-specific oligonucleotide, whereas SW x J-1 lymphomas produced 1.8-kb transcripts hybridizing with an Mtv7-specific oligonucleotide [2].
  • The immunostimulatory potential of IDDM ORF was tested on murine T cell hybridomas and compared to the well-characterized mouse mammary tumor virus Mtv7 SAg transfected in the same conditions [3].
  • We describe here the production of a monoclonal antibody (mAb), 3B12, which is peptide specific and reacts with a recombinant baculovirus product of Mtv-7 sag [4].
  • The sequence of the Mtv-7 open reading frame differs from all other known mammary tumor virus open reading frame sequences in the 3' end, suggesting that the T-cell receptor V beta specificity is conferred by the C terminus of the molecule [5].

High impact information on Mtv7

  • Using a monoclonal antibody, we detect the Mtv-7 superantigen on the surface of activated B cells, but not on T cells or resting B cells [6].
  • The structures of the V beta 17 alleles differ by two amino acid substitutions, which lie together in an area distant from the predicted site of T cell receptor interaction with peptide-MHC complexes but overlapping with that implicated in V beta 8.2 recognition of Mls-1 superantigen [7].
  • It is also immunologically indistinguishable from the murine Ly-17 alloantigen which, in turn, is tightly linked to the Mls lymphocyte activation locus [8].
  • Strongly biased usage of V beta 6 by polyoma virus-specific CD8+ cytotoxic T lymphocytes in C57BR/cdJ mice implicates T cells bearing this Mtv-7 SAG-reactive V beta domain as critical anti-polyoma tumor effector cells in vivo [9].
  • Cells expressing these mutated class II molecules efficiently presented two retroviral SAGs (Mtv-9 and Mtv-7) to T cells while they were unable to present the bacterial SAGs [10].

Biological context of Mtv7


Anatomical context of Mtv7


Associations of Mtv7 with chemical compounds


Regulatory relationships of Mtv7


Other interactions of Mtv7


Analytical, diagnostic and therapeutic context of Mtv7

  • The expression of V beta 20 was estimated by PCR in mice of different H-2 and Mls types [24].
  • This suggests that Pyvs might encode the Mtv-7 superantigen (SAG) and abrogate polyoma tumor immunosurveillance through elimination of T cells bearing specific V beta domains [9].
  • DNA typing of 110 backcross mice showed no evidence of recombination between Pyvs and Mtv-7 [9].
  • The primary mixed lymphocyte reaction of T cells to Mls-locus-disparate stimulator cells differs from that to non-self Ia antigens in several respects [25].
  • We examined the role of Mls antigens in the induction of autoimmune gastritis (AIG) in BALB/c and DBA/2 mice subjected to thymectomy [26].


  1. Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from Mtv-7. Rudy, C.K., Kraus, E., Palmer, E., Huber, B.T. J. Exp. Med. (1992) [Pubmed]
  2. META-controlled env-initiated transcripts encoding superantigens of murine Mtv29 and Mtv7 and their possible role in B cell lymphomagenesis. Sen, N., Simmons, W.J., Thomas, R.M., Erianne, G., Zhang, D.J., Jaeggli, N.S., Huang, C., Xiong, X., Tsiagbe, V.K., Ponzio, N.M., Thorbecke, G.J. J. Immunol. (2001) [Pubmed]
  3. Human endogenous retrovirus IDDMK(1,2)22 and mouse mammary tumor virus superantigens differ in their ability to stimulate murine T cell hybridomas. Azar, G.A., Thibodeau, J. Immunol. Lett. (2002) [Pubmed]
  4. Production and characterization of an Mls-1-specific monoclonal antibody. Mohan, N., Mottershead, D., Subramanyam, M., Beutner, U., Huber, B.T. J. Exp. Med. (1993) [Pubmed]
  5. Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Beutner, U., Frankel, W.N., Cote, M.S., Coffin, J.M., Huber, B.T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a). Winslow, G.M., Scherer, M.T., Kappler, J.W., Marrack, P. Cell (1992) [Pubmed]
  7. V beta 17 gene polymorphism in wild-derived mouse strains: two amino acid substitutions in the V beta 17 region greatly alter T cell receptor specificity. Cazenave, P.A., Marche, P.N., Jouvin-Marche, E., Voegtlé, D., Bonhomme, F., Bandeira, A., Coutinho, A. Cell (1990) [Pubmed]
  8. A complementary DNA clone for a macrophage-lymphocyte Fc receptor. Lewis, V.A., Koch, T., Plutner, H., Mellman, I. Nature (1986) [Pubmed]
  9. Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. Lukacher, A.E., Ma, Y., Carroll, J.P., Abromson-Leeman, S.R., Laning, J.C., Dorf, M.E., Benjamin, T.L. J. Exp. Med. (1995) [Pubmed]
  10. Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules. Thibodeau, J., Labrecque, N., Denis, F., Huber, B.T., Sékaly, R.P. J. Exp. Med. (1994) [Pubmed]
  11. Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines. Opalka, B., Kölsch, E. Eur. J. Immunol. (1983) [Pubmed]
  12. T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirus. Braun, M.Y., Jouvin-Marche, E., Marche, P.N., MacDonald, H.R., Acha-Orbea, H. Eur. J. Immunol. (1995) [Pubmed]
  13. Genetic linkage between Lym-1, Sas-1 and Mls loci. Dickler, H.B., Rosenstreich, D.L., Ahmed, A., Sachs, D.H. Immunogenetics (1980) [Pubmed]
  14. An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7). Held, W., Shakhov, A.N., Waanders, G., Scarpellino, L., Luethy, R., Kraehenbuhl, J.P., MacDonald, H.R., Acha-Orbea, H. J. Exp. Med. (1992) [Pubmed]
  15. Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. Inaba, M., Inaba, K., Hosono, M., Kumamoto, T., Ishida, T., Muramatsu, S., Masuda, T., Ikehara, S. J. Exp. Med. (1991) [Pubmed]
  16. Exogenous Mtv-7 superantigen transgene expression in major histocompatibility complex class II I-E- mice reconstituted with embryonic stem cell-derived hematopoietic stem cells. Chambers, C.A., Kang, J., Pawling, J., Huber, B., Hozumi, N., Nagy, A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. The immunobiology of T cell responses to Mls-locus-disparate stimulator cells. II. Effects of Mls-locus-disparate stimulator cells on cloned, protein antigen-specific, Ia-restricted T cell lines. Katz, M.E., Janeway, C.A. J. Immunol. (1985) [Pubmed]
  18. A locus closely linked to Mtv7 on mouse chromosome 1 influences development of acute versus chronic graft-versus-host disease in a murine model. Allen, R.D., Slayback, D.L., Harper, J.M., Aguirre, T.L., Dobkins, J.A. Clin. Immunol. (2000) [Pubmed]
  19. T cell receptor alpha-chain influences reactivity to Mls-1 in V beta 8.1 transgenic mice. Smith, H.P., Le, P., Woodland, D.L., Blackman, M.A. J. Immunol. (1992) [Pubmed]
  20. Mls-1 and Mls-2 superantigens do not control susceptibility to collagen-induced arthritis in HI and HII mice. Roger, T., Boudaly, S., Couderc, J., Seman, M. Immunology (1993) [Pubmed]
  21. The primary in vivo immune response to Mls-1 (Mtv-7 sag). Route of injection determines the immune response pattern. Andersson, M., Acha-Orbea, H. Immunology (1994) [Pubmed]
  22. Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice. Blackman, M.A., Smith, H.P., Le, P., Woodland, D.L. J. Immunol. (1993) [Pubmed]
  23. Generation of a tumorigenic milk-borne mouse mammary tumor virus by recombination between endogenous and exogenous viruses. Golovkina, T.V., Piazzon, I., Nepomnaschy, I., Buggiano, V., de Olano Vela, M., Ross, S.R. J. Virol. (1997) [Pubmed]
  24. Identification of a T cell receptor beta chain variable region, V beta 20, that is differentially expressed in various strains of mice. Six, A., Jouvin-Marche, E., Loh, D.Y., Cazenave, P.A., Marche, P.N. J. Exp. Med. (1991) [Pubmed]
  25. The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens. Janeway, C.A., Katz, M.E. J. Immunol. (1985) [Pubmed]
  26. Concomitant enhancement of the response to Mls-1a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice. Murakami, K., Hosono, M., Maruyama, H., Mori, Y., Nishio, A., Fukumoto, M., Watanabe, Y., Inaba, M., Kuribayashi, K., Sakai, M. Clin. Exp. Immunol. (1993) [Pubmed]
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