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Chemical Compound Review

CHEBI:4222     [(3R)-3-hydroxy-2,2-dimethyl- 3-[2-(2...

Synonyms: Psh-4'-P, AC1L3GTE, DB03912, C01134, 2226-71-3, ...
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Disease relevance of Phosphopantetheine


High impact information on Phosphopantetheine

  • The crystal structure of the AHL synthase, EsaI, determined at 1.8 A resolution, reveals a remarkable structural similarity to the N-acetyltransferases and defines a common phosphopantetheine binding fold as the catalytic core [6].
  • Superposition of bound adenylyl moieties from dPCoA in PPAT and ATP in aminoacyl-tRNA synthetases suggests nucleophilic attack by the 4'-phosphopantetheine on the alpha-phosphate of ATP [7].
  • Acyl carrier protein (ACP) import into chloroplasts does not require the phosphopantetheine: evidence for a chloroplast holo-ACP synthase [8].
  • Structural comparison of LipB with lipoate protein ligase A indicates that, despite conserved structural and sequence active-site features in the two enzymes, 4'-phosphopantetheine-bound octanoic acid recognition is a specific property of LipB [9].
  • This distance is too large to be covered simply by alternative positioning of a statically anchored, fully extended phosphopantetheine arm of the acyl carrier protein domain from module 5 [10].

Chemical compound and disease context of Phosphopantetheine


Biological context of Phosphopantetheine


Anatomical context of Phosphopantetheine


Associations of Phosphopantetheine with other chemical compounds


Gene context of Phosphopantetheine


Analytical, diagnostic and therapeutic context of Phosphopantetheine


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  2. The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria. Chalut, C., Botella, L., de Sousa-D'Auria, C., Houssin, C., Guilhot, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. Mootz, H.D., Finking, R., Marahiel, M.A. J. Biol. Chem. (2001) [Pubmed]
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  9. The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H., Wilmanns, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Tang, Y., Kim, C.Y., Mathews, I.I., Cane, D.E., Khosla, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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  13. Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. Rusnak, F., Sakaitani, M., Drueckhammer, D., Reichert, J., Walsh, C.T. Biochemistry (1991) [Pubmed]
  14. Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis. Gocht, M., Marahiel, M.A. J. Bacteriol. (1994) [Pubmed]
  15. Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. Kupke, T., Hernandez-Acosta, P., Steinbacher, S., Culianez-Macia, F.A. J. Biol. Chem. (2001) [Pubmed]
  16. The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives. Cartwright, J.L., Gasmi, L., Spiller, D.G., McLennan, A.G. J. Biol. Chem. (2000) [Pubmed]
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