Disease relevance of Landau-Kleffner Syndrome

• This child shows many of the main characteristics of the syndromes of "acquired aphasia with convulsive disorder" (Landau-Kleffner syndrome) and "epilepsy with continuous spike waves during sleep." Both syndromes describe probably different facets of a similar underlying, still unexplained cerebral dysfunction [1].
• The Landau-Kleffner syndrome, the continuous spikes-waves during slow sleep syndrome and the benign epilepsy of childhood with rolandic spikes are rare childhood epilepsies with unknown etiology [2].
• The association of speech and language disorders with epilepsy is well-known in children with acquired epileptic aphasia, involving such entities as Landau-Kleffner syndrome (LKS), continuous spike wave in slow wave sleep (CSWSS) epilepsy and benign partial epilepsy with centro-temporal spikes (BPECTS) [3].

Psychiatry related information on Landau-Kleffner Syndrome

• The speech disorder was prominent, but differed from that of Landau-Kleffner syndrome and of epilepsy with continuous spike and wave during slow-wave sleep [4].
• A series of 25 children, 13 females and 12 males, who had an acquired communication disorder together with epilepsy, but did not fulfil the strict criteria of the Landau-Kleffner syndrome, was studied [5].

High impact information on Landau-Kleffner Syndrome

• Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy [6].
• Regional brain glucose utilisation was investigated with PET and fluorodeoxyglucose (FDG) in a case of epileptic aphasia (Landau-Kleffner syndrome) associated with a left sylvian arachnoid cyst [7].
• This is the first case of successful treatment of acquired epileptic aphasia using felbamate [8].
• We have evaluated 17 children (aged 2.4 to 10.6 yr) with Landau-Kleffner syndrome using positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in order to determine whether there are metabolic abnormalities common to this syndrome [9].
• Intraoperative ERP recording may help improve our understanding of the relationship between epileptiform activity and aspects of language processing in Landau-Kleffner syndrome where lack of cooperation precludes detailed clinical testing [10].

Chemical compound and disease context of Landau-Kleffner Syndrome

• The use of vigabatrin in idiopathic localization-related epilepsy, idiopathic generalized epilepsy, and the Landau Kleffner syndrome have not been reported, but its evaluation in these conditions may be warranted based on the relatively excellent safety profile of vigabatrin [11].
• Our data demonstrate that in Landau-Kleffner syndrome, cerebral glucose utilization is not normal during sleep [12].
• Landau-Kleffner syndrome and atypical benign partial epilepsy of childhood: the effectiveness of acetazolamide [13].
• Landau-Kleffner syndrome responsive to levetiracetam [14].
• An expert team conducted a ten-year survey of eight children with Landau-Kleffner syndrome (LKS) identified among children referred to Polyclinic "SUVAG" in Zagreb because of hearing disturbances [15].

Analytical, diagnostic and therapeutic context of Landau-Kleffner Syndrome

• Magnetoencephalography also contributes to the clinical decision process in patients with cortical dysplasias, Landau-Kleffner syndrome and recurrent seizures after prior epilepsy surgery [16].
• Symptomatology, EEG findings, and course were found to overlap with Rolandic epilepsy, Landau-Kleffner syndrome and ESES [17].

References