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Chemical Compound Review

NSC-762     2-chloro-N-(2-chloroethyl)-N- methyl...

Synonyms: Mitoxine, Chloramin, Dimitan, Embikhine, Embiquine, ...
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Disease relevance of Chlormethine


Psychiatry related information on Chlormethine

  • The first 25 Bosnian women admitted to the Zagreb Obstetrics and Gynaecological Clinic or its associated regional psychiatric centers were assessed using both clinical and post-traumatic stress disorder interviews [6].
  • They reported also more job satisfaction and commitment than the district nurses in Zagreb [7].
  • Assessment of suicidality among veterans suffering from chronic ptsd treated at the center for crisis intervention kbc zagreb [8].
  • The frequency of substance consumption implied a generalized tendency towards substance abuse among Zagreb adolescents [9].
  • METHODS: Randomly chosen elderly aged 65-85 from Krakow (Poland) and from Zagreb and some smaller towns in Croatia were interviewed on health (self-rated health, physical functioning, mental health, perceived bodily pain, hearing and vision ability, morbidity, functional status, loneliness and depression) and general quality of life [10].

High impact information on Chlormethine

  • Incidence of IDDM during 1988-1992 in Zagreb, Croatia [2].
  • Protein-encoding nucleotide sequences of the N, P, M, F, H, and L genes were determined for a low-passage isolate of the Edmonston wild-type (wt) measles virus and five Edmonston-derived vaccine virus strains, including AIK-C, Moraten, Schwarz, Rubeovax, and Zagreb [11].
  • It is found that the optimum exponent of the variable reformulated Zagreb M2 index (v = -1/2) is identical with the exponent of the vertex-connectivity index, which is the most used topological index in QSPR and QSAR [12].
  • METHODS: 112 prostate samples from patients undergoing surgery at the Urology Clinic at the Zagreb Clinical Hospital Center from 1995 to 2003 were investigated in this study [13].
  • METHODS: One hundred forty-five sarcoidosis patients of an outpatient pulmonary clinic in Zagreb, Croatia, completed the Fatigue Assessment Scale (FAS) and QOL scale (World Health Organization Quality of Life Assessment Instrument-100) between January 2002 and May 2004 [14].

Chemical compound and disease context of Chlormethine


Biological context of Chlormethine

  • SETTING: Department of Obstetrics and Gynecology, University of Zagreb, Sveti Duh Hospital, Zagreb, Croatia [17].
  • Data on the incidence of TB were obtained from the Epidemiology Department, Institute for Lung Diseases, Zagreb, Croatia [18].
  • 10th World Congress of Ultrasound in Obstetrics & Gynecology, 4-7 October 2000, Zagreb, Croatia: presentations of the 2000 Ian Donald Medals. Presentation of the Ian Donald Gold Medal to Karek Marsal [19].
  • The patients with cancer of the larynx at the Ear, Nose and Throat Department in Zagreb during the period from 1945 to 1972, and the cases of laryngeal cancer at the Institute of Public Health of Croatia, were examined epidemiologically [20].
  • The ability of two antivenoms to Vipera spp., consisting of Fab (Therapeutic Antibodies), or of F(ab')2 (Zagreb Institute of Immunology) antibody fragments, to neutralize the hemorrhagic activity of Vipera berus snake venom in mice, was compared [21].

Anatomical context of Chlormethine


Associations of Chlormethine with other chemical compounds

  • Zebra mussels were exposed for seven days to different concentrations (10, 80, 100, 150 microg/l) of PCP and in the river Sava downstream from Zagreb municipal wastewater outlet [27].
  • METHODS: An anonymous, self-administered questionnaire was distributed to medical students in Years 2-6 at the Zagreb University School of Medicine; 827 (70%) valid questionnaires were returned and analysed [28].
  • Two clinical samples of male and female alcoholics undergoing inpatient hospital and posthospital treatment in Zagreb, Yugoslavia, were evaluated for depressive symptomatology and extent of alcoholism, using self-report measures (Zung Self-Rating Depression Scale and Michigan Alcohol Screening Test) [29].
  • Healthy blood donors from the city of Zagreb were checked for the presence of a nephrotoxic mycotoxin ochratoxin A (OTA) in the plasma [30].
  • Experience with liposomal amphotericin B at the Hematology-Oncology Department Children's Hospital Salata Medical School, University of Zagreb [31].

Gene context of Chlormethine

  • METHODS: The C677T MTHFR gene mutation was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 640 subjects, residents of the Zagreb city or Zagreb surroundings [32].
  • METHODS: Blood samples were collected from 135 healthy unrelated donors from Zagreb area previously typed for HLA class II alleles (DRB1, DQA1, DQB1) [33].
  • During a 1-month period in 1996, all inpatients and staff in the Zagreb Trauma Hospital were screened for methicillin-resistant Staphylococcus aureus (MRSA) carriage in order to control MRSA spread within the hospital [16].
  • Concentrations of 34 biochemical constituents of sera were determined on 998 randomly selected urban school children and adolescents aged 8-18 years from Zagreb, Croatia [34].
  • A novel missense mutation C127R (FH Zagreb) in the LDL-receptor gene [35].

Analytical, diagnostic and therapeutic context of Chlormethine

  • A cross-sectional study was performed on 275 pupils from the third and fourth grade of three elementary schools (three urban areas with different traffic conditions) in Zagreb [36].
  • In local health centres where the staffs are not specially trained in rabies vaccination, the Zagreb intra-muscular regimen is an economical option [37].
  • Based on a serial dilution of the live-attenuated MV Edmonston Zagreb vaccine, the detection limits were approximately 0.1 and 0.02 cell culture infectious dose 50% units (CCID50) per test for the conventional and TaqMan RT-PCR assays, respectively [38].
  • METHODS: From November 1996 to December 1997, 6700 patients who had undergone upper gastrointestinal endoscopy at the two centres in Zagreb, Croatia, were candidates for participation in the study [39].
  • The role of humic acids in the transport of trace elements in the Sava river biocycle (near Zagreb, Yugloslavia) has been investigated by means of neutron activation analysis [40].


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  32. Croatian population data for the C677T polymorphism in methylenetetrahydrofolate reductase: frequencies in healthy and atherosclerotic study groups. Zuntar, I., Topić, E., Vukosavić, D., Vuković, V., Demarin, V., Begonja, A., Antoljak, N., Simundić, A.M. Clin. Chim. Acta (2003) [Pubmed]
  33. Distribution of alleles at DQCAR microsatellite locus in the Croatian population. Grubić, Z., Zunec, R., Crkvenac, K., Cecuk-Jelicić, E., Kastelan, A. Croat. Med. J. (2000) [Pubmed]
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  36. Lead absorption and psychological function in Zagreb (Croatia) school children. Prpíc-Majíc, D., Bobícc, J., Simícc, D., House, D.E., Otto, D.A., Jurasovícc, J., Pizent, A. Neurotoxicology and teratology. (2000) [Pubmed]
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