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Disease relevance of Arachnoid


High impact information on Arachnoid

  • Gelatinolytic activity was detected earliest within the matrix of cortical blood vessels and later within neurons and pia arachnoid (> or =3 hours), particularly within piriform cortex; this activity was suppressed by injection of the metalloprotease inhibitor GM6001 or in vitro by the addition of a zinc chelator (1,10-phenanthroline) [6].
  • Here, we report PGDS to be expressed consistently in 10 human arachnoid and arachnoid villi and in 21 meningiomas by immunohistochemistry, Western blot, and reverse transcription (RT)-PCR analyses [1].
  • In contrast, in arachnoid villi, PGDS was seen in core arachnoid cells rather than in the cap cell cluster or arachnoid cell layer [1].
  • Immunoelectron microscopy showed that E-cadherin was localized at the intermediate junctions in arachnoid villi, while it was detected diffusely at the cell surface in meningiomas [7].
  • Both [3H]inulin and bleomycin were cleared from the CSF more slowly than in previous studies and more slowly than in normal dogs, which suggests that bulk CSF absorption was reduced by the drug, probably secondary to protein-induced blockage of the arachnoid granulations through which CSF is normally absorbed [8].

Chemical compound and disease context of Arachnoid


Biological context of Arachnoid


Anatomical context of Arachnoid


Associations of Arachnoid with chemical compounds


Gene context of Arachnoid


Analytical, diagnostic and therapeutic context of Arachnoid


  1. Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. Yamashima, T., Sakuda, K., Tohma, Y., Yamashita, J., Oda, H., Irikura, D., Eguchi, N., Beuckmann, C.T., Kanaoka, Y., Urade, Y., Hayaishi, O. J. Neurosci. (1997) [Pubmed]
  2. Effect of chymopapain on the meninges studied in an experimental model. Haughton, V.M., Nguyen, C.M., Ho, K.C. Radiology. (1988) [Pubmed]
  3. Pseudotumour cerebri syndrome due to cryptococcal meningitis. Cremer, P.D., Johnston, I.H., Halmagyi, G.M. J. Neurol. Neurosurg. Psychiatr. (1997) [Pubmed]
  4. Idiopathic intracranial hypertension in cystinosis. Dogulu, C.F., Tsilou, E., Rubin, B., Fitzgibbon, E.J., Kaiser-Kupper, M.I., Rennert, O.M., Gahl, W.A. J. Pediatr. (2004) [Pubmed]
  5. Posterior vertebral body erosion by arachnoid diverticula in cauda equina syndrome: an unusual manifestation of ankylosing spondylitis. Ginsburg, W.W., Cohen, M.D., Miller, G.M., Bartleson, J.D. J. Rheumatol. (1997) [Pubmed]
  6. Cortical spreading depression activates and upregulates MMP-9. Gursoy-Ozdemir, Y., Qiu, J., Matsuoka, N., Bolay, H., Bermpohl, D., Jin, H., Wang, X., Rosenberg, G.A., Lo, E.H., Moskowitz, M.A. J. Clin. Invest. (2004) [Pubmed]
  7. Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas. Tohma, Y., Yamashima, T., Yamashita, J. Cancer Res. (1992) [Pubmed]
  8. Central nervous system toxicity and cerebrospinal fluid pharmacokinetics of intraventricularly administered bleomycin in beagles. Levin, V.A., Byrd, D., Sikic, B.I., Etiz, B.B., Campbell, J., Borcich, J.K., Davis, R.L. Cancer Res. (1985) [Pubmed]
  9. Subdural hygroma in association with middle fossa arachnoid cyst: acetazolamide therapy. Choong, C.T., Lee, S.H. Brain Dev. (1998) [Pubmed]
  10. MR imaging in infra-, para- and retrosellar mass lesions. Sartor, K., Karnaze, M.G., Winthrop, J.D., Gado, M., Hodges, F.J. Neuroradiology. (1987) [Pubmed]
  11. Expression of NF2 gene product merlin in arachnoid villi and meningiomas. Sakuda, K., Kohda, Y., Matsumoto, T., Park, C., Seto, A., Tohma, Y., Hasegawa, M., Kida, S., Nitta, H., Yamashima, T., Yamashita, J. Nōshuyō byōri = Brain tumor pathology. (1996) [Pubmed]
  12. Progesterone receptors in arachnoid cysts. An immunocytochemical study in 2 cases. Go, K.G., Blankenstein, M.A., Vroom, T.M., Blaauw, E.H., Dijk, F., Hollema, H., Verhagen, A. Acta neurochirurgica. (1997) [Pubmed]
  13. Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. Chan, T., Logan, P., Eustace, P. Journal of clinical neuro-ophthalmology. (1991) [Pubmed]
  14. Expression of cell adhesion molecule E-cadherin in human arachnoid villi. Yamashima, T., Tohma, Y., Yamashita, J. J. Neurosurg. (1992) [Pubmed]
  15. A normal second-trimester ultrasound does not exclude intracranial structural pathology. Malinger, G., Lerman-Sagie, T., Watemberg, N., Rotmensch, S., Lev, D., Glezerman, M. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (2002) [Pubmed]
  16. Familial arachnoid cysts associated with oculopharyngeal muscular dystrophy. Jadeja, K.J., Grewal, R.P. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. (2003) [Pubmed]
  17. Distribution of atrial natriuretic peptide receptor subtypes in rat brain. Brown, J., Czarnecki, A. Am. J. Physiol. (1990) [Pubmed]
  18. Drug therapy against a transplantable guinea pig leukemia. Pearson, J.W., Perk, K., Chirigos, M.A., Torgersen, J.A. Cancer Res. (1975) [Pubmed]
  19. Nonabsorptive hydrocephalus associated with nephropathic cystinosis. Ross, D.L., Strife, C.F., Towbin, R., Bove, K.E. Neurology (1982) [Pubmed]
  20. Localization of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus-infected mouse eyes. Cunningham, E.T., Stalder, A., Sanna, P.P., Liu, S.S., Bloom, F.E., Howes, E.L., Campbell, I.L., Margolis, T.P. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  21. Oculocerebral malformations. A reappraisal of Walker's 'lissencephaly'. Chan, C.C., Egbert, P.R., Herrick, M.K., Urich, H. Arch. Neurol. (1980) [Pubmed]
  22. Arachnoid response to contrast media: a comparison of iophendylate and metrizamide in experimental animals. Haughton, V.M., Ho, K.C. Radiology. (1982) [Pubmed]
  23. Muscarinic binding of pial vessels and arachnoid membrane. Lasbennes, F., Verrecchia, C., Philipson, V., Seylaz, J. J. Neurochem. (1992) [Pubmed]
  24. Pia arachnoid contains substance P originating from trigeminal neurons. Liu-Chen, L.Y., Han, D.H., Moskowitz, M.A. Neuroscience (1983) [Pubmed]
  25. Brain glucose utilisation in acquired childhood aphasia associated with a sylvian arachnoid cyst: recovery after shunting as demonstrated by PET. De Volder, A.G., Michel, C., Thauvoy, C., Willems, G., Ferrière, G. J. Neurol. Neurosurg. Psychiatr. (1994) [Pubmed]
  26. Morphine and alfentanil permeability through the spinal dura, arachnoid, and pia mater of dogs and monkeys. Bernards, C.M., Hill, H.F. Anesthesiology (1990) [Pubmed]
  27. Human choroid plexus growth factors: What are the implications for CSF dynamics in Alzheimer's disease? Stopa, E.G., Berzin, T.M., Kim, S., Song, P., Kuo-LeBlanc, V., Rodriguez-Wolf, M., Baird, A., Johanson, C.E. Exp. Neurol. (2001) [Pubmed]
  28. Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Gard, A.L., Gavin, E., Solodushko, V., Pennica, D. Neuroscience (2004) [Pubmed]
  29. Distribution of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus infected trigeminal ganglia in the mouse. Cunningham, E.T., Stalder, A.K., Sanna, P.P., Liu, S.S., Bloom, F.E., Howes, E.L., Campbell, I.L., Margolis, T.P. Brain Res. (1997) [Pubmed]
  30. Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. Akat, K., Mennel, H.D., Kremer, P., Gassler, N., Bleck, C.K., Kartenbeck, J. Acta Neuropathol. (2003) [Pubmed]
  31. Dural enhancement and cerebral displacement secondary to intracranial hypotension. Fishman, R.A., Dillon, W.P. Neurology (1993) [Pubmed]
  32. Cytokeratin provides a specific marker for human arachnoid cells grown in vitro. Frank, E.H., Burge, B.W., Liwnicz, B.H., Lotspeich, L.J., White, J.C., Wechsler, S.L., Mayfield, F.H., Keller, J.T. Exp. Cell Res. (1983) [Pubmed]
  33. Expression of PDGF beta-receptors in human meningioma cells. Wang, J.L., Nistér, M., Hermansson, M., Westermark, B., Pontén, J. Int. J. Cancer (1990) [Pubmed]
  34. What is the relationship between arachnoid cysts and seizure foci? Arroyo, S., Santamaria, J. Epilepsia (1997) [Pubmed]
  35. Quantitative cine-mode magnetic resonance imaging of Chiari I malformations: an analysis of cerebrospinal fluid dynamics. Armonda, R.A., Citrin, C.M., Foley, K.T., Ellenbogen, R.G. Neurosurgery (1994) [Pubmed]
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