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Disease relevance of Aphasia


Psychiatry related information on Aphasia


High impact information on Aphasia

  • Low activity in striatal and posterior periventricular areas was also seen in the 8 children with ADHD in combination with phonologic-syntactic dysphasia [11].
  • Six patients had surgery; 1 with right-sided IAP language dominance but left-sided PET activation had dysphasia for 6 months after left temporal lobectomy [12].
  • A factor analysis indicated three factors corresponding to the Affective Flattening or Blunting subscale, the Avolition-Apathy and Anhedonia-Asociality subscales, and the Alogia and Inattention subscales [13].
  • Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia [14].
  • A 55-year-old woman with an aortic arch syndrome of acute onset and dysphasia, resulting from the excessive administration of ergotamine tartrate suppositories, is described [15].

Chemical compound and disease context of Aphasia

  • After 3 weeks of treatment with clobazam 20 mg a day, the patient developed, in association with his seizures, a neologistic jargon dysphasia but with loss of inflection, volume, and rhythm of speech, presumably as a result of the effect of the clobazam [16].
  • Therefore, this behavioural dimension accounts for the variance of the SD2R, suggesting that the striatal dopamine system modulates symptoms such as flattened affect and alogia [17].
  • Regional brain blood flow in congenital dysphasia: studies with technetium-99m HM-PAO SPECT [18].
  • Sulfasalazine induced seizures and dysphasia [19].
  • It is likely that the transient expressive dysphasia experienced by the four patients reported here was a neurotoxic reaction, rather than a seizure phenomenon [20].

Biological context of Aphasia


Gene context of Aphasia

  • Alzheimer disease and nonfluent progressive aphasia [22].
  • Of all symptom measures derived from SANS and Manchester Scales, only alogia was related to verbal fluency in that superior improvement correlated inversely with the degree of alogia [23].
  • These data, although not incompatible with the hypothesis of a direct route for action, are better accommodated by the idea of a distributed semantic memory, where different types of knowledge are represented, as proposed by Allport (Allport, D. A. Current perspectives in dysphasia, pp. 32-60. Churchill Livingstone, Edinburgh, 1985) [24].
  • A 33-year-old right-handed woman had intractable simple and complex partial seizures (SPS, CPS) that began with global aphasia [25].
  • RESULTS: Poor Wisconsin Card Sorting Test performance inversely correlated with insight in schizophrenic patients, as did the symptoms alogia, anhedonia, avolition/apathy, affective flattening, inappropriate affect, thought disorder and delusions [26].

Analytical, diagnostic and therapeutic context of Aphasia


  1. Positive response to immunomodulatory therapy in an adult patient with Rasmussen's encephalitis. Villani, F., Spreafico, R., Farina, L., Giovagnoli, A.R., Bernasconi, P., Granata, T., Avanzini, G. Neurology (2001) [Pubmed]
  2. A case of Landau-Kleffner syndrome secondary to inflammatory demyelinating disease. Perniola, T., Margari, L., Buttiglione, M., Andreula, C., Simone, I.L., Santostasi, R. Epilepsia (1993) [Pubmed]
  3. Partially successful treatment of Rasmussen's encephalitis with zidovudine: symptomatic improvement followed by involvement of the contralateral hemisphere. DeToledo, J.C., Smith, D.B. Epilepsia (1994) [Pubmed]
  4. Dysphoric and depressive symptoms in chronic schizophrenia. Hirsch, S.R., Jolley, A.G., Barnes, T.R., Liddle, P.F., Curson, D.A., Patel, A., York, A., Bercu, S., Patel, M. Schizophr. Res. (1989) [Pubmed]
  5. Tuberculosis of the nervous system. A clinical, radiological and pathological study of 39 consecutive cases in Riyadh, Saudi Arabia. Bahemuka, M., Murungi, J.H. J. Neurol. Sci. (1989) [Pubmed]
  6. Cognition and anatomy in three variants of primary progressive aphasia. Gorno-Tempini, M.L., Dronkers, N.F., Rankin, K.P., Ogar, J.M., Phengrasamy, L., Rosen, H.J., Johnson, J.K., Weiner, M.W., Miller, B.L. Ann. Neurol. (2004) [Pubmed]
  7. Focal cerebral hypoperfusion in children with dysphasia and/or attention deficit disorder. Lou, H.C., Henriksen, L., Bruhn, P. Arch. Neurol. (1984) [Pubmed]
  8. Language laterality assessed by unilateral ECT and dichotic monitoring. Geffen, G., Traub, E., Stierman, I. J. Neurol. Neurosurg. Psychiatr. (1978) [Pubmed]
  9. Progressive aphemia in a patient with Pick's disease: a neuropsychological and anatomic study. Sakurai, Y., Murayama, S., Fukusako, Y., Bando, M., Iwata, M., Inoue, K. J. Neurol. Sci. (1998) [Pubmed]
  10. Hypothalamic digoxin and hemispheric chemical dominance: relation to speech and language dysfunction. Kurup, R.K., Kurup, P.A. Int. J. Neurosci. (2003) [Pubmed]
  11. Focal cerebral dysfunction in developmental learning disabilities. Lou, H.C., Henriksen, L., Bruhn, P. Lancet (1990) [Pubmed]
  12. (15)O water positron emission tomography in language localization: a study comparing positron emission tomography visual and computerized region of interest analysis with the Wada test. Hunter, K.E., Blaxton, T.A., Bookheimer, S.Y., Figlozzi, C., Gaillard, W.D., Grandin, C., Anyanwu, A., Theodore, W.H. Ann. Neurol. (1999) [Pubmed]
  13. A multisite investigation of the reliability of the Scale for the Assessment of Negative Symptoms. Mueser, K.T., Sayers, S.L., Schooler, N.R., Mance, R.M., Haas, G.L. The American journal of psychiatry. (1994) [Pubmed]
  14. Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia. Yancopoulou, D., Xuereb, J.H., Crowther, R.A., Hodges, J.R., Spillantini, M.G. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
  15. Transient aortic arch syndrome with dysphasia due to ergotism. Feneley, M.P., Morgan, J.J., McGrath, M.A., Egan, J.D. Stroke (1983) [Pubmed]
  16. Paroxysmal language disturbance in an epileptic treated with clobazam. Wilson, A., Petty, R., Perry, A., Rose, F.C. Neurology (1983) [Pubmed]
  17. Central D2 receptors and negative symptoms of schizophrenia. Martinot, J.L., Paillère-Martinot, M.L., Loc'h, C., Lecrubier, Y., Dao-Castellana, M.H., Aubin, F., Allilaire, J.F., Mazoyer, B., Mazière, B., Syrota, A. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  18. Regional brain blood flow in congenital dysphasia: studies with technetium-99m HM-PAO SPECT. Denays, R., Tondeur, M., Foulon, M., Verstraeten, F., Ham, H., Piepsz, A., Noël, P. J. Nucl. Med. (1989) [Pubmed]
  19. Sulfasalazine induced seizures and dysphasia. Hill, M.E., Gordon, C., Situnayake, R.D., Heath, D.A. J. Rheumatol. (1994) [Pubmed]
  20. Transient expressive (nonfluent) dysphasia after metrizamide myelography. Sarno, J.B. AJNR. American journal of neuroradiology. (1985) [Pubmed]
  21. A pedigree with a novel presenilin 1 mutation at a residue that is not conserved in presenilin 2. Yasuda, M., Maeda, K., Hashimoto, M., Yamashita, H., Ikejiri, Y., Bird, T.D., Tanaka, C., Schellenberg, G.D. Arch. Neurol. (1999) [Pubmed]
  22. Alzheimer disease and nonfluent progressive aphasia. Greene, J.D., Patterson, K., Xuereb, J., Hodges, J.R. Arch. Neurol. (1996) [Pubmed]
  23. Verbal fluency in schizophrenia: relationship with executive function, semantic memory and clinical alogia. Joyce, E.M., Collinson, S.L., Crichton, P. Psychological medicine. (1996) [Pubmed]
  24. Identification without manipulation: a study of the relations between object use and semantic memory. Moreaud, O., Charnallet, A., Pellat, J. Neuropsychologia. (1998) [Pubmed]
  25. Global aphasia with seizure onset in the dominant basal temporal region. Abou-Khalil, B., Welch, L., Blumenkopf, B., Newman, K., Whetsell, W.O. Epilepsia (1994) [Pubmed]
  26. Insight: its relationship with cognitive function, brain volume and symptoms in schizophrenia. Rossell, S.L., Coakes, J., Shapleske, J., Woodruff, P.W., David, A.S. Psychological medicine. (2003) [Pubmed]
  27. Dopamine autoreceptor agonists in the treatment of schizophrenic disorders. Wetzel, H., Benkert, O. Prog. Neuropsychopharmacol. Biol. Psychiatry (1993) [Pubmed]
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