Disease relevance of Phenylketonuria, Maternal

• Timing of strict diet in relation to fetal damage in maternal phenylketonuria. An international collaborative study by the MRC/DHSS Phenylketonuria Register [1].
• Congenital heart disease in maternal phenylketonuria: report from the Maternal PKU Collaborative Study [2].
• Developmental neurotoxicity: do similar phenotypes indicate a common mode of action? A comparison of fetal alcohol syndrome, toluene embryopathy and maternal phenylketonuria [3].

Psychiatry related information on Phenylketonuria, Maternal

• The best-known example of this is maternal phenylketonuria (PKU), which produces microcephaly, mental retardation, congenital heart disease and intrauterine growth retardation [4].

High impact information on Phenylketonuria, Maternal

• Phenylpyruvate, fetal damage, and maternal phenylketonuria syndrome [5].
• Most expert panels recommend following a phenylalanine-restricted "diet for life." However, there are few adult physicians dedicated to continuing care of this group, with the possible exception of maternal phenylketonuria [6].
• BACKGROUND: Branched-chain amino acids have been reported to improve fetal brain development in a rat model in which maternal phenylketonuria (PKU) is induced by the inclusion of an inhibitor of phenylalanine hydroxylase, DL-p-chlorophenylalanine, and L-phenylalanine in the diet [7].
• Tyrosine supplementation in the treatment of maternal phenylketonuria [8].
• L-tryptophan in maternal phenylketonuria [9].

Chemical compound and disease context of Phenylketonuria, Maternal

• The incorporation of D-[U-14C]glucosamine into N-acetylneuraminic acid bound to glycoproteins was appreciably diminished in the rat pup previously exposed to maternal phenylketonuria induced by phenyl acetate [10].
• Potential role of tetrahydrobiopterin in the treatment of maternal phenylketonuria [11].

Biological context of Phenylketonuria, Maternal

• Relationship among genotype, biochemical phenotype, and cognitive performance in females with phenylalanine hydroxylase deficiency: report from the Maternal Phenylketonuria Collaborative Study [12].

Anatomical context of Phenylketonuria, Maternal

• Effects of phenylalanine loading on protein synthesis in the fetal heart and brain of rat: an experimental approach to maternal phenylketonuria [13].

Gene context of Phenylketonuria, Maternal

• Ultrasonographic failure of early detection of fetal microcephaly in maternal phenylketonuria [14].
• Development retardation was caused by maternal phenylketonuria, which may also have been responsible for the development of the ventricular septal defect and the coronary anomaly [15].

References