Disease relevance of Mandibular Advancement

• PURPOSE: Reports of irreversible alteration in jaw posture and destructive occlusal contact relationships in individuals using mandibular advancement devices for obstructive sleep apnea are beginning to appear [1].
• Altered jaw posture and occlusal disruption patterns following mandibular advancement therapy for sleep apnea: a preliminary study of cephalometric predictors [1].

Psychiatry related information on Mandibular Advancement

• The aims of this longitudinal, observational study were two-fold: first, to determine in adults with sleep disorders the extent of dental and occlusal changes following the use of a mandibular advancement splint (MAS) and, second, to determine the time course of these changes [2].

High impact information on Mandibular Advancement

• Assuming this effect on upper airway calibre is not eliminated by sleep, mandibular advancement oral appliances may reduce the severity of obstructive sleep apnoea by maintaining patency of the velopharynx, particularly in its lateral dimension [3].
• Mandibular advancement elicited Runx2 expression in condylar cartilage, and subsequently led to an expansion of type X collagen domain in the hypertrophic layer [4].
• Thus, mandibular advancement promoted mesenchymal cell differentiation and triggered PTHrP expression, which retarded their further maturation to allow for more growth [5].
• Self-reinforced biodegradable screw fixation compared with titanium screw fixation in mandibular advancement [6].
• MATERIALS AND METHODS: One hundred sixty-one patients (121 men and 40 women, mean age: 54.3 +/- 13.7 years) diagnosed with mild to moderate OSAS (mean apnea-hypopnea index: 17.9 +/- 14.1) were studied before and after insertion of a mandibular advancement device, with a mean interval of 60 days [7].

Anatomical context of Mandibular Advancement

• The purpose of this study was to evaluate the pattern of expression of PTHrP and correlate it to cellular dynamics of chondrocytes in condylar cartilage during natural growth and mandibular advancement [5].

Associations of Mandibular Advancement with chemical compounds

• Dental and occlusal changes during mandibular advancement splint therapy in sleep disordered patients [2].
• The different pattern of movement of C2 and C3 in mandibular advancement and mandibular set-back, respectively, confirmed the conclusion that the initiating mechanisms, may be found in the cervicothoracic transition and the upper cervical region, respectively [8].

Gene context of Mandibular Advancement

• Results showed that mechanical strain produced by mandibular advancement induced neovascularization in the posterior condyle marked by the increased expression of VEGF [9].
• Mandibular advancement using an intra-oral osteogenic distraction technique: a report of three clinical cases [10].
• To quantitatively assess the amount of mRNA expression of Cbfa1 and type X collagen in response to mandibular advancement [11].
• At T2, a slight tendency toward disc retrusion because of mandibular advancement was observed, but, at T3, the disc returned to normal, similar to T1 values [12].
• CONCLUSIONS: Progressive mandibular advancement was not associated with greater mandibular growth compared with single-step advancement [13].

Analytical, diagnostic and therapeutic context of Mandibular Advancement

• CONCLUSIONS: Two-mm self-reinforced PLLDL (70/30) screws can be used as effectively as 2-mm titanium screws to stabilize the mandible after bilateral sagittal osteotomies for mandibular advancement [6].

References