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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, bcl-1

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Disease relevance of Genes, bcl-1


High impact information on Genes, bcl-1

  • Specifically, 15 samples (from 14 patients) of CD5-expressing B-cell NHLs with detectable bcl-1 gene rearrangement were included [1].
  • The bcl-1 gene maps to chromosome 11q13 and has recently been shown to be a member of the cyclin gene family [6].
  • No abnormalities were detected in the c-myc and bcl-1 genes, but two of 17 patients were found to have N-ras mutations by differential oligonucleotide hybridization and dideoxynucleotide sequencing following amplification by polymerase chain reaction [7].
  • Addition of exogenous erythropoietin to tumor cell lines expressing erythropoietin receptor increased nuclear DNA binding activity of nuclear factor kappa B and increased the expression of the antiapoptotic genes bcl-1, bcl-xL, and mcl-1 [8].
  • We have demonstrated that MTC bcl-1 gene rearrangements can be amplified from formalin-fixed tissue [9].

Anatomical context of Genes, bcl-1


Gene context of Genes, bcl-1

  • To address this question, we have studied amplification of c-myc, HER2/neu and int-2/bcl-1 genes in a series of 1052 collected human breast tumours [11].


  1. CD5-expressing B-cell non-Hodgkin's lymphomas with bcl-1 gene rearrangement have a relatively homogeneous immunophenotype and are associated with an overall poor prognosis. Segal, G.H., Masih, A.S., Fox, A.C., Jorgensen, T., Scott, M., Braylan, R.C. Blood (1995) [Pubmed]
  2. Immunohistochemical expression of cyclin D1, E2F-1, and Ki-67 in benign and malignant thyroid lesions. Saiz, A.D., Olvera, M., Rezk, S., Florentine, B.A., McCourty, A., Brynes, R.K. J. Pathol. (2002) [Pubmed]
  3. Mantle cell lymphoma. Rapid polymerase chain reaction-based genotyping of a morphologically heterogeneous entity. Segal, G.H., Maiese, R.L. Arch. Pathol. Lab. Med. (1996) [Pubmed]
  4. CD23 negative chronic lymphocytic leukemia of the tonsil: report of a case. Ampil, F.L., Veillon, D.M., Nordberg, M.L., Nathan, C.A., Kunjumoideen, K., Cotelingam, J.D. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. (2002) [Pubmed]
  5. Bcl-1 rearrangement and cyclin D1 protein expression in multiple myeloma precursor cells. Liu, X., Tang, Z., Zou, P. J. Tongji Med. Univ. (2000) [Pubmed]
  6. Amplification and expression of the bcl-1 gene in human solid tumor cell lines. Faust, J.B., Meeker, T.C. Cancer Res. (1992) [Pubmed]
  7. Oncogenes in multiple myeloma: point mutation of N-ras. Paquette, R.L., Berenson, J., Lichtenstein, A., McCormick, F., Koeffler, H.P. Oncogene (1990) [Pubmed]
  8. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Batra, S., Perelman, N., Luck, L.R., Shimada, H., Malik, P. Lab. Invest. (2003) [Pubmed]
  9. Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues. Lim, L.C., Segal, G.H., Wittwer, C.T. Am. J. Clin. Pathol. (1995) [Pubmed]
  10. Frequent amplification of 11q13 DNA markers is associated with lymph node involvement in human head and neck squamous cell carcinomas. Muller, D., Millon, R., Lidereau, R., Engelmann, A., Bronner, G., Flesch, H., Eber, M., Methlin, G., Abecassis, J. Eur. J. Cancer, B, Oral Oncol. (1994) [Pubmed]
  11. Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors. Berns, E.M., Klijn, J.G., van Staveren, I.L., Portengen, H., Noordegraaf, E., Foekens, J.A. Eur. J. Cancer (1992) [Pubmed]
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