Disease relevance of Genes, bcl-1

• Mantle cell lymphomas (MCLs) are typically CD5-expressing B-cell non-Hodgkin's lymphomas (NHLs) that frequently harbor the chromosomal translocation t(11;14) or bcl-1 gene rearrangements [1].
• Cyclin D1, a product of the bcl-1 gene, phosphorylates the retinoblastoma protein, releasing E2F-1, which in turn activates genes involved in DNA synthesis [2].
• CONCLUSIONS: Presented is an extremely rapid, nonisotopic polymerase chain reaction-based method that detects IgH and major translocation cluster bcl-1 gene rearrangements in mantle cell lymphoma [3].
• The diagnosis of CD23 negative chronic lymphocytic leukemia was made after further molecular studies failed to detect the bcl-1 gene rearrangement [4].
• The rearrangement of Bcl-1 gene (Bcl-1/IgH rearrangement) and expression of cyclin D1 in multiple myeloma (MM) precursor cells were studied and the role of cyclin D1 in the pathogenesis of MM was investigated [5].

High impact information on Genes, bcl-1

• Specifically, 15 samples (from 14 patients) of CD5-expressing B-cell NHLs with detectable bcl-1 gene rearrangement were included [1].
• The bcl-1 gene maps to chromosome 11q13 and has recently been shown to be a member of the cyclin gene family [6].
• No abnormalities were detected in the c-myc and bcl-1 genes, but two of 17 patients were found to have N-ras mutations by differential oligonucleotide hybridization and dideoxynucleotide sequencing following amplification by polymerase chain reaction [7].
• Addition of exogenous erythropoietin to tumor cell lines expressing erythropoietin receptor increased nuclear DNA binding activity of nuclear factor kappa B and increased the expression of the antiapoptotic genes bcl-1, bcl-xL, and mcl-1 [8].
• We have demonstrated that MTC bcl-1 gene rearrangements can be amplified from formalin-fixed tissue [9].

Anatomical context of Genes, bcl-1

• Coamplification of hst-1/FGF4 and bcl-1 genes was found in 57% of primary tumours and in 60% of the 89 metastatic lymph nodes tested [10].

Gene context of Genes, bcl-1

• To address this question, we have studied amplification of c-myc, HER2/neu and int-2/bcl-1 genes in a series of 1052 collected human breast tumours [11].

References