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Gene Review

BCL2L1  -  BCL2-like 1

Homo sapiens

Synonyms: Apoptosis regulator Bcl-X, BCL-XL/S, BCL2L, BCLX, BCLXL, ...
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Disease relevance of BCL2L1


High impact information on BCL2L1


Chemical compound and disease context of BCL2L1


Biological context of BCL2L1


Anatomical context of BCL2L1

  • Bcl-X was strongly increased during the terminal differentiation stages of human and mouse erythroblasts, reaching maximum transcript and protein levels at the time of maximum hemoglobin synthesis [14].
  • This is accompanied by lowered bcl2-like immunoreactivity and increased poly(ADP-ribose) polymerase cleavage and cytochrome c translocation into the cytosol [15].
  • To assess its clinical significance in patients with follicular lymphoma, realtime quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis of bcl-xL gene expression was investigated in whole lymph node sections and laser-microdissected lymphoma cells of 27 patients [2].
  • In patients with mastocytosis, the expression of bcl-2 protein but not bcl-xL in cutaneous mast cells was significantly enhanced, compared to healthy controls [3].
  • In contrast to the skin lesions, bone marrow infiltrates of patients with systemic mastocytosis showed only low or absent immunoreactivity for bcl-2, but marked expression of bcl-xL [3].

Associations of BCL2L1 with chemical compounds

  • Clinically, a high bcl-xL level was significantly associated with multiple sites of extranodal involvement (P =.0020), elevated lactate dehydrogenase level (P =.0478), and an International Prognostic Index indicating high risk (P =.0235) [2].
  • Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity [16].
  • When activated, these death ligands engage pro-survival Bcl-2-like proteins via the BH3 domain, inactivating their function [17].
  • STI571 failed to activate caspase cascades or to suppress expression of survival genes (bcl-xL) in resistant cells [18].
  • By GenBank database searches and PCR, we have identified a novel human Bcl2-like gene, Bcl2-L-10, which contains conserved BH4, BH1 and BH2 domains but lacks BH3 domain [19].

Regulatory relationships of BCL2L1

  • Treatment with a subtoxic concentration of a bispecific bcl-2/bcl xL antisense oligonucleotide cooperated with okadaic acid to down-regulate bcl-2 and sensitize cyclin D1-overexpressing cells to okadaic acid [20].
  • Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma [21].
  • Accordingly, we found that SCF up-regulates Bcl-2 and Bcl-X L in erythroid precursors and that exogenous expression of these proteins protects erythroblasts from caspase activation and death induced by chemotherapeutic agents [22].
  • The ability of CD28 to enhance survival during T cell activation correlated positively with its ability to up-regulate the protein product of the cell survival gene bcl-xL [23].
  • In contrast to many other anticancer agents to which the apoptotic response is decreased because of p53 mutations, our data suggest that the bcl-2/bcl-xL bispecific antisense oligonucleotide 4625 effectively induces p53-independent apoptosis in human C8161 melanoma cells [24].

Other interactions of BCL2L1


Analytical, diagnostic and therapeutic context of BCL2L1


  1. Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines. Perego, P., Righetti, S.C., Supino, R., Delia, D., Caserini, C., Carenini, N., Bedogné, B., Broome, E., Krajewski, S., Reed, J.C., Zunino, F. Apoptosis (1997) [Pubmed]
  2. Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma. Zhao, W.L., Daneshpouy, M.E., Mounier, N., Brière, J., Leboeuf, C., Plassa, L.F., Turpin, E., Cayuela, J.M., Ameisen, J.C., Gisselbrecht, C., Janin, A. Blood (2004) [Pubmed]
  3. Expression of Bcl-2 and Bcl-xL in cutaneous and bone marrow lesions of mastocytosis. Hartmann, K., Artuc, M., Baldus, S.E., Zirbes, T.K., Hermes, B., Thiele, J., Mekori, Y.A., Henz, B.M. Am. J. Pathol. (2003) [Pubmed]
  4. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Boise, L.H., González-García, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nuñez, G., Thompson, C.B. Cell (1993) [Pubmed]
  5. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Pollman, M.J., Hall, J.L., Mann, M.J., Zhang, L., Gibbons, G.H. Nat. Med. (1998) [Pubmed]
  6. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Yang, X., Chang, H.Y., Baltimore, D. Science (1998) [Pubmed]
  7. Combined targeted inhibition of bcl-2, bcl-XL, epidermal growth factor receptor, and protein kinase A type I causes potent antitumor, apoptotic, and antiangiogenic activity. Tortora, G., Caputo, R., Damiano, V., Caputo, R., Troiani, T., Veneziani, B.M., De Placido, S., Bianco, A.R., Zangemeister-Wittke, U., Ciardiello, F. Clin. Cancer Res. (2003) [Pubmed]
  8. Taxol and estramustine-induced modulation of human prostate cancer cell apoptosis via alteration in bcl-xL and bak expression. Liu, Q.Y., Stein, C.A. Clin. Cancer Res. (1997) [Pubmed]
  9. Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Epperly, M.W., Sikora, C.A., DeFilippi, S.J., Gretton, J.A., Zhan, Q., Kufe, D.W., Greenberger, J.S. Radiat. Res. (2002) [Pubmed]
  10. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex. Peter, M.E., Kischkel, F.C., Scheuerpflug, C.G., Medema, J.P., Debatin, K.M., Krammer, P.H. Eur. J. Immunol. (1997) [Pubmed]
  11. Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. Ibrahim, S.M., Ringel, J., Schmidt, C., Ringel, B., Müller, P., Koczan, D., Thiesen, H.J., Löhr, M. Pancreas (2001) [Pubmed]
  12. Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestation. Shynlova, O., Oldenhof, A., Dorogin, A., Xu, Q., Mu, J., Nashman, N., Lye, S.J. Biol. Reprod. (2006) [Pubmed]
  13. DNA methylation levels in porcine fetal fibroblasts induced by an inhibitor of methylation, 5-azacytidine. Mohana Kumar, B., Jin, H.F., Kim, J.G., Song, H.J., Hong, Y., Balasubramanian, S., Choe, S.Y., Rho, G.J. Cell Tissue Res. (2006) [Pubmed]
  14. The roles of Bcl-X(L) and apopain in the control of erythropoiesis by erythropoietin. Gregoli, P.A., Bondurant, M.C. Blood (1997) [Pubmed]
  15. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. Alves da Costa, C., Mattson, M.P., Ancolio, K., Checler, F. J. Biol. Chem. (2003) [Pubmed]
  16. Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. Slavik, J.M., Lim, D.G., Burakoff, S.J., Hafler, D.A. J. Biol. Chem. (2004) [Pubmed]
  17. Life in the balance: how BH3-only proteins induce apoptosis. Willis, S.N., Adams, J.M. Curr. Opin. Cell Biol. (2005) [Pubmed]
  18. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Donato, N.J., Wu, J.Y., Stapley, J., Gallick, G., Lin, H., Arlinghaus, R., Talpaz, M. Blood (2003) [Pubmed]
  19. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. Zhang, H., Holzgreve, W., De Geyter, C. Hum. Mol. Genet. (2001) [Pubmed]
  20. Cyclin D1 overexpression induces epidermal growth factor-independent resistance to apoptosis linked to BCL-2 in human A431 carcinoma. Rieber, M., Rieber, M.S. Apoptosis (2006) [Pubmed]
  21. Effect of bax, bcl-2 and bcl-xL on regulating apoptosis in tissues of normal liver and hepatocellular carcinoma. Guo, X.Z., Shao, X.D., Liu, M.P., Xu, J.H., Ren, L.N., Zhao, J.J., Li, H.Y., Wang, D. World J. Gastroenterol. (2002) [Pubmed]
  22. Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins. Zeuner, A., Pedini, F., Signore, M., Testa, U., Pelosi, E., Peschle, C., De Maria, R. Blood (2003) [Pubmed]
  23. CD28 costimulation prevents cell death during primary T cell activation. Noel, P.J., Boise, L.H., Green, J.M., Thompson, C.B. J. Immunol. (1996) [Pubmed]
  24. p53-Independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide. Strasberg Rieber, M., Zangemeister-Wittke, U., Rieber, M. Clin. Cancer Res. (2001) [Pubmed]
  25. Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes. Fang, W., Rivard, J.J., Mueller, D.L., Behrens, T.W. J. Immunol. (1994) [Pubmed]
  26. Novel BNIP1 variants and their interaction with BCL2 family members. Zhang, H., Heim, J., Meyhack, B. FEBS Lett. (1999) [Pubmed]
  27. Coexpression of genes involved in apoptosis in central nervous system neoplasms. Bruggers, C.S., Fults, D., Perkins, S.L., Coffin, C.M., Carroll, W.L. J. Pediatr. Hematol. Oncol. (1999) [Pubmed]
  28. Expression of apoptosis-controlling proteins in acute leukemia cells. Campos, L., Sabido, O., Viallet, A., Vasselon, C., Guyotat, D. Leuk. Lymphoma (1999) [Pubmed]
  29. Inducing apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z by bcl-xL short hairpin RNA. He, C.W., Liu, F., Zhang, Y.F., Liang, T., Zhou, K.Y. Ai Zheng (2005) [Pubmed]
  30. 20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome. Smith, L.T., Mayerson, J., Nowak, N.J., Suster, D., Mohammed, N., Long, S., Auer, H., Jones, S., McKeegan, C., Young, G., Bos, G., Plass, C., Morrison, C. Genes Chromosomes Cancer (2006) [Pubmed]
  31. Candidate gene screening for posterior polymorphous dystrophy. Aldave, A.J., Yellore, V.S., Principe, A.H., Abedi, G., Merrill, K., Chalukya, M., Small, K.W., Udar, N. Cornea (2005) [Pubmed]
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