Disease relevance of Caryophyllaceae

• Prophylaxis of calcium oxalate stones by Herniaria hirsuta on experimentally induced nephrolithiasis in rats [1].
• The effects on the calcium oxalate urolithiasis urinary risk factors of Herniaria hirsuta L [2].

High impact information on Caryophyllaceae

• Extract from Herniaria hirsuta coats calcium oxalate monohydrate crystals and blocks their adhesion to renal epithelial cells [3].
• Two new cyclic peptides, drymarins A and B, were isolated from the whole plants of Drymaria diandra B1 [4].
• The proteins have molecular masses of 30.2 kDa (S. ocymoides) and 28.0 kDa (V. pyramidata) and pI greater than 9.5, their N-terminal amino acid sequences are similar to those of saporin-S6 and dianthin 30, ribosome-inactivating proteins from other Caryophyllaceae, and they partially cross-react with sera against these proteins [5].
• A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra [6].
• Triterpenoid saponins from Spergularia ramosa [7].

Associations of Caryophyllaceae with chemical compounds

• Plants of the genus Gypsophila (Caryophyllaceae) are important industrially because of the capacity of their saponin constituents to behave like natural detergents.1 Saponins from this genus are based on oleanolic acid (3-hydroxyolean-12-en-28-oic acid), with gypsogenin being the main pentacyclic triterpenoidal aglycon found [8].
• Hypoglycaemic effect of spergularia purpurea in normal and streptozotocin-induced diabetic rats [9].
• The methanol extract of Drymaria cordata Willd. was investigated for its effect on a cough model induced by sulfur dioxide gas in mice [10].
• Cholesterol-lowering activity of the aqueous extract of Spergularia purpurea in normal and recent-onset diabetic rats [11].
• Urinary oxalate increased significantly during the second week for untreated rats and remained constant in rats treated with Herniaria decoction [12].

Analytical, diagnostic and therapeutic context of Caryophyllaceae

• The purpose of this study was to determine the underlying mechanism of the hypoglycemic activity of the aqueous extract perfusion of Spergularia purpurea (SP) in diabetic mice and streptozotocin-induced diabetic rats [13].
• Single and repeated oral administration of the water extracts of Spergularia purpurea (SP) at a dose of 10 mg/kg were tested on hypoglycaemic activity in normal and streptozotocin-induced diabetic rats [9].

References