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MeSH Review

Kidney Calculi

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Disease relevance of Kidney Calculi


Psychiatry related information on Kidney Calculi


High impact information on Kidney Calculi


Chemical compound and disease context of Kidney Calculi


Biological context of Kidney Calculi


Anatomical context of Kidney Calculi


Gene context of Kidney Calculi

  • Concentrations and relative amounts of TFF1 in the urine of patients with idiopathic CaOx kidney stone were significantly less (2.5-fold for the concentrations and 5- to 22-fold for the relative amounts) than those found in controls [25].
  • Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders [26].
  • We find trpm7 expression in the mesonephric kidney and show that mutants develop kidney stones, indicating renal dysfunction [27].
  • 5. The protein encoded by ORG has a similar pattern of expression and identical structural features to nephrocalcin, a calcium-binding protein partially purified from kidney that plays a role in calcium reabsorption and in prevention of nephrolithiasis [28].
  • Mutations in the CLCN5 gene have been demonstrated in three disorders of hypercalciuric nephrolithiasis, i.e., Dent's disease, X-linked recessive nephrolithiasis, and X-linked recessive hypophosphatemic rickets [29].

Analytical, diagnostic and therapeutic context of Kidney Calculi


  1. X-linked recessive nephrolithiasis with renal failure. Wrong, O., Norden, A.G., Feest, T.G. N. Engl. J. Med. (1992) [Pubmed]
  2. An inheritable anomaly of red-cell oxalate transport in "primary" calcium nephrolithiasis correctable with diuretics. Baggio, B., Gambaro, G., Marchini, F., Cicerello, E., Tenconi, R., Clementi, M., Borsatti, A. N. Engl. J. Med. (1986) [Pubmed]
  3. Abnormal red-cell calcium pump in patients with idiopathic hypercalciuria. Bianchi, G., Vezzoli, G., Cusi, D., Cova, T., Elli, A., Soldati, L., Tripodi, G., Surian, M., Ottaviano, E., Rigatti, P. N. Engl. J. Med. (1988) [Pubmed]
  4. Bone biopsy to diagnose hyperoxaluria in patients with renal failure. Mathews, M., Stauffer, M., Cameron, E.C., Maloney, N., Sherrard, D.J. Ann. Intern. Med. (1979) [Pubmed]
  5. Oxypurinol nephrolithiasis in regional enteritis secondary to allopurinol therapy. Stote, R.M., Smith, L.H., Dubb, J.W., Moyer, T.P., Alexander, F., Roth, J.L. Ann. Intern. Med. (1980) [Pubmed]
  6. 'Bad dietary habits' and recurrent calcium oxalate nephrolithiasis. Hess, B. Nephrol. Dial. Transplant. (1998) [Pubmed]
  7. Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Reilly, R.F., Ellison, D.H. Physiol. Rev. (2000) [Pubmed]
  8. A key stone cop regulates oxalate homeostasis. Kleta, R. Nat. Genet. (2006) [Pubmed]
  9. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Jiang, Z., Asplin, J.R., Evan, A.P., Rajendran, V.M., Velazquez, H., Nottoli, T.P., Binder, H.J., Aronson, P.S. Nat. Genet. (2006) [Pubmed]
  10. A randomized double-blind study of acetohydroxamic acid in struvite nephrolithiasis. Williams, J.J., Rodman, J.S., Peterson, C.M. N. Engl. J. Med. (1984) [Pubmed]
  11. A common molecular basis for three inherited kidney stone diseases. Lloyd, S.E., Pearce, S.H., Fisher, S.E., Steinmeyer, K., Schwappach, B., Scheinman, S.J., Harding, B., Bolino, A., Devoto, M., Goodyer, P., Rigden, S.P., Wrong, O., Jentsch, T.J., Craig, I.W., Thakker, R.V. Nature (1996) [Pubmed]
  12. Triamterene-induced nephrolithiasis. Grunberg, R.W., Silberg, S.J. JAMA (1981) [Pubmed]
  13. Urine glycoprotein crystal growth inhibitors. Evidence for a molecular abnormality in calcium oxalate nephrolithiasis. Nakagawa, Y., Abram, V., Parks, J.H., Lau, H.S., Kawooya, J.K., Coe, F.L. J. Clin. Invest. (1985) [Pubmed]
  14. The presence of protein-bound gamma-carboxyglutamic acid in calcium-containing renal calculi. Lian, J.B., Prien, E.L., Glimcher, M.J., Gallop, P.M. J. Clin. Invest. (1977) [Pubmed]
  15. Thymine-requiring bacteria associated with co-trimoxazole therapy. Maskell, R., Okubadejo, O.A., Payne, R.H. Lancet (1976) [Pubmed]
  16. Correction of erythrocyte abnormalities in idiopathic calcium-oxalate nephrolithiasis and reduction of urinary oxalate by oral glycosaminoglycans. Baggio, B., Gambaro, G., Marchini, F., Marzaro, G., Williams, H.E., Borsatti, A. Lancet (1991) [Pubmed]
  17. Suggestive evidence for a susceptibility gene near the vitamin D receptor locus in idiopathic calcium stone formation. Scott, P., Ouimet, D., Valiquette, L., Guay, G., Proulx, Y., Trouvé, M.L., Gagnon, B., Bonnardeaux, A. J. Am. Soc. Nephrol. (1999) [Pubmed]
  18. Association of urinary pH with body weight in nephrolithiasis. Maalouf, N.M., Sakhaee, K., Parks, J.H., Coe, F.L., Adams-Huet, B., Pak, C.Y. Kidney Int. (2004) [Pubmed]
  19. Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney. Kleinman, J.G., Beshensky, A., Worcester, E.M., Brown, D. Kidney Int. (1995) [Pubmed]
  20. Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold. Burall, L.S., Harro, J.M., Li, X., Lockatell, C.V., Himpsl, S.D., Hebel, J.R., Johnson, D.E., Mobley, H.L. Infect. Immun. (2004) [Pubmed]
  21. Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity. Hricik, D.E., Goldsmith, G.H. Am. J. Med. (1988) [Pubmed]
  22. An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells. Sorokina, E.A., Wesson, J.A., Kleinman, J.G. J. Am. Soc. Nephrol. (2004) [Pubmed]
  23. Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. Kohjimoto, Y., Kennington, L., Scheid, C.R., Honeyman, T.W. Kidney Int. (1999) [Pubmed]
  24. Disruption of clc-5 leads to a redistribution of annexin A2 and promotes calcium crystal agglomeration in collecting duct epithelial cells. Carr, G., Simmons, N.L., Sayer, J.A. Cell. Mol. Life Sci. (2006) [Pubmed]
  25. Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor. Chutipongtanate, S., Nakagawa, Y., Sritippayawan, S., Pittayamateekul, J., Parichatikanond, P., Westley, B.R., May, F.E., Malasit, P., Thongboonkerd, V. J. Clin. Invest. (2005) [Pubmed]
  26. Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders. Lloyd, S.E., Gunther, W., Pearce, S.H., Thomson, A., Bianchi, M.L., Bosio, M., Craig, I.W., Fisher, S.E., Scheinman, S.J., Wrong, O., Jentsch, T.J., Thakker, R.V. Hum. Mol. Genet. (1997) [Pubmed]
  27. Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7. Elizondo, M.R., Arduini, B.L., Paulsen, J., MacDonald, E.L., Sabel, J.L., Henion, P.D., Cornell, R.A., Parichy, D.M. Curr. Biol. (2005) [Pubmed]
  28. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. Desbois, C., Hogue, D.A., Karsenty, G. J. Biol. Chem. (1994) [Pubmed]
  29. Mutations in CLCN5 chloride channel in Japanese patients with low molecular weight proteinuria. Morimoto, T., Uchida, S., Sakamoto, H., Kondo, Y., Hanamizu, H., Fukui, M., Tomino, Y., Nagano, N., Sasaki, S., Marumo, F. J. Am. Soc. Nephrol. (1998) [Pubmed]
  30. Diagnosis of hyperparathyroidism. Bone, H.G., Snyder, W.H., Pak, C.Y. Annu. Rev. Med. (1977) [Pubmed]
  31. Experimental calcium oxalate nephrolithiasis in the rat. Role of the renal papilla. Khan, S.R., Finlayson, B., Hackett, R.L. Am. J. Pathol. (1982) [Pubmed]
  32. Direct correlation between hyperoxaluria/oxalate stone disease and the absence of the gastrointestinal tract-dwelling bacterium Oxalobacter formigenes: possible prevention by gut recolonization or enzyme replacement therapy. Sidhu, H., Schmidt, M.E., Cornelius, J.G., Thamilselvan, S., Khan, S.R., Hesse, A., Peck, A.B. J. Am. Soc. Nephrol. (1999) [Pubmed]
  33. Primary hyperparathyroidism presenting as anticonvulsant-induced osteomalacia. Broadus, A.E., Hanson, T.A., Bartter, F.C., Walton, J. Am. J. Med. (1977) [Pubmed]
  34. Hyperoxaluria and calcium oxalate nephrolithiasis after jejunoileal bypass. Stauffer, J.Q. Am. J. Clin. Nutr. (1977) [Pubmed]
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