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MeSH Review

Euonymus

 
 
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Disease relevance of Euonymus

  • Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) [1].
 

High impact information on Euonymus

  • We have isolated a gene from developing seeds of Euonymus alatus that shows a very high sequence similarity to the members of the DGAT1 gene family (i.e. related to acyl-CoA:cholesterol acyltransferases) [2].
  • 1,2-Diacyl-3-acetyl-sn-glycerols (ac-TAG) are unusual triacylglycerols that constitute the major storage lipid in the seeds of Euonymus alatus (Burning Bush) [2].
  • Two structurally different chitin-binding proteins were isolated from bark and leaves of the spindle tree (Euonymus europaeus L.). Both the small hevein-like chitin-binding protein (Ee-CBP) and the classical class-I chitinase (Ee-chitinase) possess antifungal properties, Ee-CBP being far more potent than Ee-chitinase [3].
  • The carbohydrate binding preferences of the Galalpha3Galbeta4 GlcNAc-binding lectins from Marasmius oreades and Euonymus europaeus were examined by binding to glycosphingolipids on thin-layer chromatograms and in microtiter wells [4].
  • Laxifolone A is a triterpene isolated from Euonymus laxiflorus Champ [5].
 

Associations of Euonymus with chemical compounds

  • Euonymoside A: a new cytotoxic cardenolide glycoside from the bark of Euonymus sieboldianus [6].
  • Furthermore, the lectins Euonymus europaeus (EE) specific for the carbohydrates gal alpha 1-3 gal present a similar lytic activity against T. cruzi at the same concentrations of purified anti-gal antibodies [7].
  • The binding of K88 fimbriae to mucus proteins was blocked using a lectin of Euonymus europeaus which specifically recognizes the Gal alpha(1-3)Gal sequence, indicating that this disaccharide forms a significant part of the receptor structure [8].
  • A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus [9].
  • The lectin of Euonymus europaeus at concentrations of 5-21 micrograms/ml causes activation of the classical complement (C) pathway (C1, C4, C2) when added to normal human serum at 37 degrees C. At higher concentrations, C3 is also consumed [10].
 

Gene context of Euonymus

  • Caffeic acid (CA), a strong and selective MMP-9 activity and transcription inhibitor, was isolated from the plant Euonymus alatus and its derivative, caffeic acid phenethyl ester (CAPE), was synthesized [11].
  • Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells [12].
 

Analytical, diagnostic and therapeutic context of Euonymus

  • Seven blood group H active glycopeptides were isolated from the defatted seeds of Euonymus Sieboldiana by a procedure that included extraction with cold phosphate-buffered saline, fractionation with ammonium sulfate, chromatography with CM- and DEAE Sepharose CL 6B, and gel filtration on Sepharose 4B and Sephacryl S-200 [13].
  • Purification of the Euonymus europaeus lectin by affinity chromatography on the desialized MN blood group glycoprotein, and lectin NH2-terminal analysis [14].

References

  1. Inhibitory effects of triptogelin A-1 on 12-O-tetradecanoylphorbol-13- acetate-induced skin tumor promotion. Ujita, K., Takaishi, Y., Tokuda, H., Nishino, H., Iwashima, A., Fujita, T. Cancer Lett. (1993) [Pubmed]
  2. Isolation of a gene encoding a 1,2-diacylglycerol-sn-acetyl-CoA acetyltransferase from developing seeds of Euonymus alatus. Milcamps, A., Tumaney, A.W., Paddock, T., Pan, D.A., Ohlrogge, J., Pollard, M. J. Biol. Chem. (2005) [Pubmed]
  3. Synergistic antifungal activity of two chitin-binding proteins from spindle tree (Euonymus europaeus L.). Van den Bergh, K.P., Rougé, P., Proost, P., Coosemans, J., Krouglova, T., Engelborghs, Y., Peumans, W.J., Van Damme, E.J. Planta (2004) [Pubmed]
  4. Studies on Galalpha3-binding proteins: comparison of the glycosphingolipid binding specificities of Marasmius oreades lectin and Euonymus europaeus lectin. Teneberg, S., Alsén, B., Angström, J., Winter, H.C., Goldstein, I.J. Glycobiology (2003) [Pubmed]
  5. Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level. Ko, H.C., Kuo, Y.H., Wei, B.L., Chiou, W.F. Planta Med. (2005) [Pubmed]
  6. Euonymoside A: a new cytotoxic cardenolide glycoside from the bark of Euonymus sieboldianus. Baek, N.I., Lee, Y.H., Park, J.D., Kim, S.I., Ahn, B.Z. Planta Med. (1994) [Pubmed]
  7. Direct lysis of Trypanosoma cruzi: a novel effector mechanism of protection mediated by human anti-gal antibodies. Gazzinelli, R.T., Pereira, M.E., Romanha, A., Gazzinelli, G., Brener, Z. Parasite Immunol. (1991) [Pubmed]
  8. Age and serotype dependent binding of K88 fimbriae to porcine intestinal receptors. Willemsen, P.T., de Graaf, F.K. Microb. Pathog. (1992) [Pubmed]
  9. A phenolic compound, 5-caffeoylquinic acid (chlorogenic acid), is a new type and strong matrix metalloproteinase-9 inhibitor: isolation and identification from methanol extract of Euonymus alatus. Jin, U.H., Lee, J.Y., Kang, S.K., Kim, J.K., Park, W.H., Kim, J.G., Moon, S.K., Kim, C.H. Life Sci. (2005) [Pubmed]
  10. Effect of sequential glycolysis of the lectin of Euonymus europaeus on activation of the classical complement pathway in normal human serum. Schultz, D.R., Arnold, P.I. Mol. Immunol. (1982) [Pubmed]
  11. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism. Chung, T.W., Moon, S.K., Chang, Y.C., Ko, J.H., Lee, Y.C., Cho, G., Kim, S.H., Kim, J.G., Kim, C.H. FASEB J. (2004) [Pubmed]
  12. Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells. Lee, T.K., Kim, D.I., Han, J.Y., Kim, C.H. Immunopharmacology and immunotoxicology. (2004) [Pubmed]
  13. Purification, composition and immunochemical properties of arabinogalactan-protein H active glycopeptides from Euonymus sieboldiana seeds. Yamamoto, S., Sakai, I., Iseki, S. Immunol. Commun. (1981) [Pubmed]
  14. Purification of the Euonymus europaeus lectin by affinity chromatography on the desialized MN blood group glycoprotein, and lectin NH2-terminal analysis. Petryniak, J., Janusz, M., Markowska, E., Lisowska, E. Acta Biochim. Pol. (1981) [Pubmed]
 
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