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MeSH Review


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Disease relevance of Schisandra

  • Previous studies in our laboratory have demonstrated the effect of Schisandrin B (Sch B),an active ingredient of the fruit of Schisandra chinensis, on enhancing the hepatic glutathione antioxidant system in mice, as evidenced by the hepatoprotection against carbon tetrachloride (CCl4) toxicity [1].
  • It is concluded that the therapeutic effect of TJ-108 on chronic hepatitis C is from the inhibitory effect on HCV infection, and also from the protective effect on immunological hepatopathy of Schisandra Fruit and its lignan component, Gomisin A [2].

High impact information on Schisandra

  • Micrandilactone A: A Novel Triterpene from Schisandra micrantha [3].
  • A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells [4].
  • We isolated and characterized two agonists of human NPFF2 receptor, PC 314 with K(i) of 1.42muM, and PC 315 with K(i) of 2.17muM from Schizandra chinensis [5].
  • Here, we show that schisandrin B, a naturally occurring compound from Schisandra chinensis (Turcz.) Baill, bears strong potency to inhibit P-glycoprotein [6].
  • Under the optimal conditions (5 mM borate-5 mM phosphate buffer in the presence of 20 mM SDS and 10 mM BMIM-BF4, pH 9.2, applied voltage 25 kV and detection at 254 nm), the method successfully applied to the determination of lignans in extracts of Schisandra chinensis (Turcz.) Baill. and Schisandra henryi C.B. Clarke in less than 13 min [7].

Anatomical context of Schisandra


Associations of Schisandra with chemical compounds

  • The hepatoprotective effect of Gomisin A (TJN-101), which is a lignan compound isolated from Schizandra fruits, was studied on three immunologic liver injury models in mice [9].
  • The seed extract of Schisandra chinensis was investigated in the rat for its restorative or therapeutic effect on Phase I hepatic drug metabolism following intoxication by carbon tetrachloride (CCl4) [10].
  • Data obtained from intoxicated animals treated by Schisandra extract, compared to those without treatment, showed significant (p < 0.05) improvement in the t1/2 (4.45 +/- 1.7 h) and Cl/F (0.096 +/- 0.018 ml/h) estimates of antipyrine and a 2-3 fold increase in P450 level (0.190 +/- 0.072 nmol/mg protein) [10].
  • The effect of a lignan-enriched extract of the fruits of Schisandra chinensis (FS) on hepatic glutathione (GSH) status was examined in both control and carbon tetrachloride (CCl4)-treated rats [11].
  • The present study was conducted to identify Schisandra fruit components having inhibitory effects on CYP3A4 by surveying the effect on human liver microsomal erythromycin N-demethylation activity [12].

Gene context of Schisandra

  • Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract [12].
  • Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis [13].
  • The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis [14].
  • Treatment of rats with a lignan-enriched extract of the fruit of Schisandra chinensis could enhance hepatic antioxidant/detoxification system, as indicated by increases in hepatic reduced glutathione (GSH) level as well as hepatic glutathione reductase and glutathione S-transferase activities [15].
  • This review focuses primarily on the SAS-mediated stimulating effects of single doses of adaptogens derived from Rhodiola rosea, Schizandra chinensis and Eleutherococcus senticosus [16].

Analytical, diagnostic and therapeutic context of Schisandra

  • Applicability of these synthetic adsorbents, especially the polymethacrylic adsorbents, was verified by the separation of polyunsaturated fatty acids, schizandrin in Schisandra chinensis fruit, tocopherols and tocotrienols in vegetable oils using a 10-microm adsorbent packed into an HPLC column [17].
  • Since heavy physical exercise increases the content of nitric oxide and cortisol in blood and saliva, standardized extracts of the adaptogen herbal drugs Schizandra chinensis and Bryonia alba roots were applied to several groups of athletes in a placebo controlled double blind study [8].


  1. Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver. Ip, S.P., Poon, M.K., Che, C.T., Ng, K.H., Kong, Y.C., Ko, K.M. Free Radic. Biol. Med. (1996) [Pubmed]
  2. Clinical and pharmacological studies on liver diseases treated with Kampo herbal medicine. Cyong, J.C., Ki, S.M., Iijima, K., Kobayashi, T., Furuya, M. Am. J. Chin. Med. (2000) [Pubmed]
  3. Micrandilactone A: A Novel Triterpene from Schisandra micrantha. Li, R.T., Zhao, Q.S., Li, S.H., Han, Q.B., Sun, H.D., Lu, Y., Zhang, L.L., Zheng, Q.T. Org. Lett. (2006) [Pubmed]
  4. Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. Kim, S.R., Lee, M.K., Koo, K.A., Kim, S.H., Sung, S.H., Lee, N.G., Markelonis, G.J., Oh, T.H., Yang, J.H., Kim, Y.C. J. Neurosci. Res. (2004) [Pubmed]
  5. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Do, E.U., Piao, L.Z., Choi, G., Choi, Y.B., Kang, T.M., Shin, J., Chang, Y.J., Nam, H.Y., Kim, H.J., Kim, S.I. Peptides (2006) [Pubmed]
  6. Schisandrin B--a novel inhibitor of P-glycoprotein. Qiangrong, P., Wang, T., Lu, Q., Hu, X. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Separation and determination of lignans from seeds of Schisandra species by micellar electrokinetic capillary chromatography using ionic liquid as modifier. Tian, K., Qi, S., Cheng, Y., Chen, X., Hu, Z. Journal of chromatography. A. (2005) [Pubmed]
  8. Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva. Panossian, A.G., Oganessian, A.S., Ambartsumian, M., Gabrielian, E.S., Wagner, H., Wikman, G. Phytomedicine (1999) [Pubmed]
  9. The effect of gomisin A on immunologic liver injury in mice. Nagai, H., Yakuo, I., Aoki, M., Teshima, K., Ono, Y., Sengoku, T., Shimazawa, T., Aburada, M., Koda, A. Planta Med. (1989) [Pubmed]
  10. Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model. Zhu, M., Yeung, R.Y., Lin, K.F., Li, R.C. Planta Med. (2000) [Pubmed]
  11. Effect of a lignan-enriched fructus schisandrae extract on hepatic glutathione status in rats: protection against carbon tetrachloride toxicity. Ko, K.M., Ip, S.P., Poon, M.K., Wu, S.S., Che, C.T., Ng, K.H., Kong, Y.C. Planta Med. (1995) [Pubmed]
  12. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Iwata, H., Tezuka, Y., Kadota, S., Hiratsuka, A., Watabe, T. Drug Metab. Dispos. (2004) [Pubmed]
  13. Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. Lee, I.S., Lee, H.K., Dat, N.T., Lee, M.S., Kim, J.W., Na, D.S., Kim, Y.H. Planta Med. (2003) [Pubmed]
  14. The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis. Wu, M.D., Huang, R.L., Kuo, L.M., Hung, C.C., Ong, C.W., Kuo, Y.H. Chem. Pharm. Bull. (2003) [Pubmed]
  15. Effect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in rats. Ip, S.P., Mak, D.H., Li, P.C., Poon, M.K., Ko, K.M. Pharmacol. Toxicol. (1996) [Pubmed]
  16. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Panossian, A., Wagner, H. Phytotherapy research : PTR. (2005) [Pubmed]
  17. Use of synthetic adsorbents in preparative normal-phase liquid chromatography. Adachi, T., Isobe, E. Journal of chromatography. A. (2003) [Pubmed]
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