The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pyrularia


High impact information on Pyrularia


Biological context of Pyrularia


Anatomical context of Pyrularia

  • Treating NIH3T3 fibroblast cells with Pyrularia pubera thionin (100 micrograms/ml) stimulated release of labelled free fatty acids from phospholipids biosynthetically labelled by incorporation of [3H]arachidonic acid [8].
  • The results of the recent study (VERNON, L. P. and ROGERS, A., Toxicon 30, 701-709) agree with this companion study on the binding of 125I-labeled pyrularia thionin and cardiotoxin to erythrocytes under the same conditions [9].
  • Effects of different antagonists on depolarization of cultured chick myotubes by cobra venom cardiotoxins and Pyrularia thionin from the plant Pyrularia pubera [10].

Associations of Pyrularia with chemical compounds


Gene context of Pyrularia

  • Dopamine, a physiological inhibitor of prolactin release that closes calcium channels, decreased prolactin release stimulated by Pyrularia thionin [11].
  • We have chosen the Pyrularia pubera thionin, a 47-residue peptide with four internal disulfides and a remarkable resistance to most proteases, as a representative member of this type of cysteine-rich peptides and have shown that a combination of partial reduction and cyanylation readily allows the determination of its disulfide bonds [14].


  1. Synthetic and structural studies on Pyrularia pubera thionin: a single-residue mutation enhances activity against Gram-negative bacteria. Vila-Perelló, M., Sánchez-Vallet, A., García-Olmedo, F., Molina, A., Andreu, D. FEBS Lett. (2003) [Pubmed]
  2. Enhancement of adenylate cyclase activity in S49 lymphoma cell membranes by the toxin thionin from Pyrularia pubera. Huang, W., Vernon, L.P., Bell, J.D. Toxicon (1994) [Pubmed]
  3. Cellular responses to Pyrularia thionin are mediated by Ca2+ influx and phospholipase A2 activation and are inhibited by thionin tyrosine iodination. Evans, J., Wang, Y.D., Shaw, K.P., Vernon, L.P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Interactions of thionin from Pyrularia pubera with dipalmitoylphosphatidylglycerol large unilamellar vesicles. Huang, W., Vernon, L.P., Hansen, L.D., Bell, J.D. Biochemistry (1997) [Pubmed]
  5. Induction of interleukin-6 release by interleukin-1 in rat anterior pituitary cells in vitro: evidence for an eicosanoid-dependent mechanism. Spangelo, B.L., Jarvis, W.D., Judd, A.M., MacLeod, R.M. Endocrinology (1991) [Pubmed]
  6. cDNA-derived identification of novel thionin precursors in Viscum album that contain highly divergent thionin domains but conserved signal and acidic polypeptide domains. Schrader-Fischer, G., Apel, K. Plant Mol. Biol. (1993) [Pubmed]
  7. A toxic thionin from Pyrularia pubera: purification, properties, and amino acid sequence. Vernon, L.P., Evett, G.E., Zeikus, R.D., Gray, W.R. Arch. Biochem. Biophys. (1985) [Pubmed]
  8. Phospholipase activation in the cytotoxic mechanism of thionin purified from nuts of Pyrularia pubera. Angerhofer, C.K., Shier, W.T., Vernon, L.P. Toxicon (1990) [Pubmed]
  9. Binding properties of Pyrularia thionin and Naja naja kaouthia cardiotoxin to human and animal erythrocytes and to murine P388 cells. Vernon, L.P., Rogers, A. Toxicon (1992) [Pubmed]
  10. Effects of different antagonists on depolarization of cultured chick myotubes by cobra venom cardiotoxins and Pyrularia thionin from the plant Pyrularia pubera. Chen, X.H., Harvey, A.L. Toxicon (1993) [Pubmed]
  11. Pyrularia thionin increases arachidonate liberation and prolactin and growth hormone release from anterior pituitary cells. Judd, A.M., Vernon, L.P., MacLeod, R.M. Toxicon (1992) [Pubmed]
  12. Role of Tyr and Trp in membrane responses of Pyrularia thionin determined by optical and NMR spectra following Tyr iodination and Trp modification. Fracki, W.S., Li, D., Owen, N., Perry, C., Naisbitt, G.H., Vernon, L.P. Toxicon (1992) [Pubmed]
  13. Hemolytic activity of thionin from Pyrularia pubera nuts and snake venom toxins of Naja naja species: Pyrularia thionin and snake venom cardiotoxin compete for the same membrane site. Osorio e Castro, V.R., Vernon, L.P. Toxicon (1989) [Pubmed]
  14. Characterization and structural role of disulfide bonds in a highly knotted thionin from Pyrularia pubera. Vila-Perelló, M., Andreu, D. Biopolymers (2005) [Pubmed]
WikiGenes - Universities