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Gene Review

Il1b  -  interleukin 1 beta

Rattus norvegicus

Synonyms: IL-1 beta, Interleukin-1 beta
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Disease relevance of Il1b


Psychiatry related information on Il1b


High impact information on Il1b

  • In contrast to the effect of the Ab in mesenteric preparations treated with IL-1 beta, leukocyte extravasation induced by topical or intraperitoneal administration of the chemotactic peptide formyl-methionyl-leucyl-phenylalanine was not inhibited by the anti-PECAM-1 Ab [9].
  • In contrast, IL-1 beta induces the expression of iNOS and also inhibits insulin secretion by both intact islets and Facs-purified beta cells, whereas TNF+LPS have no inhibitory effects on insulin secretion by purified beta cells [10].
  • Also, Lewis astrocytes produce TNF-alpha in response to IFN-gamma/IL-1 beta [11].
  • Furthermore, Lewis and BN astrocytes produce another cytokine, IL-6, in response to LPS, IFN-gamma, and IL-1 beta in a comparable fashion [11].
  • Group II PLA2 activity of glomerular mesangial cells stimulated by interleukin-1 beta was enhanced by bile juice and various bile salts [12].

Chemical compound and disease context of Il1b


Biological context of Il1b


Anatomical context of Il1b


Associations of Il1b with chemical compounds


Physical interactions of Il1b


Regulatory relationships of Il1b


Other interactions of Il1b


Analytical, diagnostic and therapeutic context of Il1b


  1. Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. Shioi, T., Matsumori, A., Kihara, Y., Inoko, M., Ono, K., Iwanaga, Y., Yamada, T., Iwasaki, A., Matsushima, K., Sasayama, S. Circ. Res. (1997) [Pubmed]
  2. Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat. Flory, C.M., Jones, M.L., Miller, B.F., Warren, J.S. Am. J. Pathol. (1995) [Pubmed]
  3. Triiodothyronine potentiates the stimulatory effects of interleukin-1 beta on bone resorption and medium interleukin-6 content in fetal rat limb bone cultures. Tarjan, G., Stern, P.H. J. Bone Miner. Res. (1995) [Pubmed]
  4. Alcohol consumption attenuates febrile responses to lipopolysaccharide and interleukin-1 beta in male rats. Taylor, A.N., Tio, D.L., Heng, N.S., Yirmiya, R. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  5. p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1 beta and footshock in conscious rats. Zheng, R.M., Zou, C.J., Zhu, S.G. Acta Pharmacol. Sin. (2004) [Pubmed]
  6. Interaction between alcohol and interleukin-1 beta on ACTH secretion and the expression of immediate early genes in the hypothalamus. Lee, S., Rivier, C. Mol. Cell. Neurosci. (1994) [Pubmed]
  7. Divergent effects of interleukin-1 beta on steroidogenesis and matrix metalloproteinase inhibitor expression and activity in cultured rat granulosa cells. Nothnick, W.B., Curry, T.E. Endocrinology (1996) [Pubmed]
  8. ACTH response induced in capsaicin-desensitized rats by intravenous injection of interleukin-1 or prostaglandin E. Watanabe, T., Morimoto, A., Tan, N., Makisumi, T., Shimada, S.G., Nakamori, T., Murakami, N. J. Physiol. (Lond.) (1994) [Pubmed]
  9. An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. Wakelin, M.W., Sanz, M.J., Dewar, A., Albelda, S.M., Larkin, S.W., Boughton-Smith, N., Williams, T.J., Nourshargh, S. J. Exp. Med. (1996) [Pubmed]
  10. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. Corbett, J.A., McDaniel, M.L. J. Exp. Med. (1995) [Pubmed]
  11. Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains. Chung, I.Y., Norris, J.G., Benveniste, E.N. J. Exp. Med. (1991) [Pubmed]
  12. Liver cirrhosis induces renal and liver phospholipase A2 activity in rats. Vishwanath, B.S., Frey, F.J., Escher, G., Reichen, J., Frey, B.M. J. Clin. Invest. (1996) [Pubmed]
  13. The involvement of bradykinin B1 and B2 receptor mechanisms in cytokine-induced mechanical hyperalgesia in the rat. Davis, A.J., Perkins, M.N. Br. J. Pharmacol. (1994) [Pubmed]
  14. Interleukin-10 stimulates rat pancreatic islets in vitro, but fails to protect against interleukin-1. Sandler, S., Welsh, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  15. Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. Spangelo, B.L., Horrell, S., Goodwin, A.L., Shroff, S., Jarvis, W.D. Neuroimmunomodulation (2004) [Pubmed]
  16. Interleukin-1 beta and tumor necrosis factor-alpha synergistically induce NO synthase in rat vascular smooth muscle cells. Beasley, D., Eldridge, M. Am. J. Physiol. (1994) [Pubmed]
  17. Cytokine mRNA expression in postischemic/reperfused myocardium. Herskowitz, A., Choi, S., Ansari, A.A., Wesselingh, S. Am. J. Pathol. (1995) [Pubmed]
  18. A role for the extracellular signal-regulated kinase and p38 mitogen-activated protein kinases in interleukin-1 beta-stimulated delayed signal tranducer and activator of transcription 3 activation, atrial natriuretic factor expression, and cardiac myocyte morphology. Ng, D.C., Long, C.S., Bogoyevitch, M.A. J. Biol. Chem. (2001) [Pubmed]
  19. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. Li, D., Zimmerman, T.L., Thevananther, S., Lee, H.Y., Kurie, J.M., Karpen, S.J. J. Biol. Chem. (2002) [Pubmed]
  20. Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes. Allan, S.M., Lawrence, C.B., Rothwell, N.J. Mol. Psychiatry (1998) [Pubmed]
  21. TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans. Andersen, N.A., Larsen, C.M., Mandrup-Poulsen, T. Diabetologia (2000) [Pubmed]
  22. Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells. Schini, V.B., Catovsky, S., Schray-Utz, B., Busse, R., Vanhoutte, P.M. Circ. Res. (1994) [Pubmed]
  23. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Ungureanu-Longrois, D., Balligand, J.L., Okada, I., Simmons, W.W., Kobzik, L., Lowenstein, C.J., Kunkel, S.L., Michel, T., Kelly, R.A., Smith, T.W. Circ. Res. (1995) [Pubmed]
  24. Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Kitade, H., Sakitani, K., Inoue, K., Masu, Y., Kawada, N., Hiramatsu, Y., Kamiyama, Y., Okumura, T., Ito, S. Hepatology (1996) [Pubmed]
  25. Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. Kuwata, H., Nakatani, Y., Murakami, M., Kudo, I. J. Biol. Chem. (1998) [Pubmed]
  26. Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. Ulich, T.R., Guo, K.Z., Irwin, B., Remick, D.G., Davatelis, G.N. Am. J. Pathol. (1990) [Pubmed]
  27. Synergistic interaction of interleukin-1 beta and growth factors in primary cultures of rat aortic smooth muscle cells. Bourcier, T., Dockter, M., Hassid, A. J. Cell. Physiol. (1995) [Pubmed]
  28. IL-1 beta, IL-1 receptor type I and iNOS gene expression in rat brain vasculature and perivascular areas. Wong, M.L., Bongiorno, P.B., al-Shekhlee, A., Esposito, A., Khatri, P., Licinio, J. Neuroreport (1996) [Pubmed]
  29. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. Gouze, J.N., Bianchi, A., Bécuwe, P., Dauça, M., Netter, P., Magdalou, J., Terlain, B., Bordji, K. FEBS Lett. (2002) [Pubmed]
  30. Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells. Mawet, E., Shiratori, Y., Hikiba, Y., Takada, H., Yoshida, H., Okano, K., Komatsu, Y., Matsumura, M., Niwa, Y., Omata, M. Hepatology (1996) [Pubmed]
  31. Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappa B and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways. Eberhardt, W., Huwiler, A., Beck, K.F., Walpen, S., Pfeilschifter, J. J. Immunol. (2000) [Pubmed]
  32. Induction of guanosine triphosphate-cyclohydrolase by follicle-stimulating hormone enhances interleukin-1 beta-stimulated nitric oxide synthase activity in granulosa cells. Tabraue, C., Diaz Peñate, R., Gallardo, G., Hernandez, I., Quintana, J., Lopez Blanco, F., Gonzalez Reyes, J., Fanjul, L.F., Ruiz de Galarreta, C.M. Endocrinology (1997) [Pubmed]
  33. Interleukin-1 beta enhances survival and interleukin-6 protects against MPP+ neurotoxicity in cultures of fetal rat dopaminergic neurons. Akaneya, Y., Takahashi, M., Hatanaka, H. Exp. Neurol. (1995) [Pubmed]
  34. Hypothalamic interleukin-1 beta and tumor necrosis factor-alpha, but not interleukin-6, mediate the endotoxin-induced suppression of the reproductive axis in rats. Watanobe, H., Hayakawa, Y. Endocrinology (2003) [Pubmed]
  35. Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Yoshida, M., Yoshimura, N., Hangai, M., Tanihara, H., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  36. Interleukin-1 beta protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo. Diem, R., Hobom, M., Grötsch, P., Kramer, B., Bähr, M. Mol. Cell. Neurosci. (2003) [Pubmed]
  37. Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Duval, D.L., Miller, D.R., Collier, J., Billings, R.E. Mol. Pharmacol. (1996) [Pubmed]
  38. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis. Wenzel, U., Schneider, A., Valente, A.J., Abboud, H.E., Thaiss, F., Helmchen, U.M., Stahl, R.A. Kidney Int. (1997) [Pubmed]
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