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Chemical Compound Review

DPPG     2,3-dihexadecanoyloxypropoxy- (2,3...

Synonyms: AGN-PC-00HD38, CHEBI:60724, AC1L22OY, C16:0 PG, 4537-77-3, ...
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Disease relevance of Dipalmitoylphosphatidylglycerol

  • Liposomes composed of distearoylphosphatidylcholine, cholesterol, dipalmitoylphosphatidylglycerol and appropriate RGD analogs were injected intravenously along with B16BL6 murine melanoma cells into mice [1].
  • Furthermore, liposomal DPP-CNDAC reduced the acute toxicity, and liposomes containing PGlcUA showed more enhanced activities of reducing tumor growth and increasing the lifetime of the mice than liposomes containing DPPG [2].

High impact information on Dipalmitoylphosphatidylglycerol


Biological context of Dipalmitoylphosphatidylglycerol


Anatomical context of Dipalmitoylphosphatidylglycerol


Associations of Dipalmitoylphosphatidylglycerol with other chemical compounds


Gene context of Dipalmitoylphosphatidylglycerol


Analytical, diagnostic and therapeutic context of Dipalmitoylphosphatidylglycerol


  1. Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs. Oku, N., Tokudome, Y., Koike, C., Nishikawa, N., Mori, H., Saiki, I., Okada, S. Life Sci. (1996) [Pubmed]
  2. Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization. Asai, T., Kurohane, K., Shuto, S., Awano, H., Matsuda, A., Tsukada, H., Namba, Y., Okada, S., Oku, N. Biol. Pharm. Bull. (1998) [Pubmed]
  3. Surfactant protein A binds Mycoplasma pneumoniae with high affinity and attenuates its growth by recognition of disaturated phosphatidylglycerols. Piboonpocanun, S., Chiba, H., Mitsuzawa, H., Martin, W., Murphy, R.C., Harbeck, R.J., Voelker, D.R. J. Biol. Chem. (2005) [Pubmed]
  4. Insertion of Alzheimer's A beta 40 peptide into lipid monolayers. Ege, C., Lee, K.Y. Biophys. J. (2004) [Pubmed]
  5. Secondary structure and lipid interactions of the N-terminal segment of pulmonary surfactant SP-C in Langmuir films: IR reflection-absorption spectroscopy and surface pressure studies. Bi, X., Flach, C.R., Pérez-Gil, J., Plasencia, I., Andreu, D., Oliveira, E., Mendelsohn, R. Biochemistry (2002) [Pubmed]
  6. Simulations of zwitterionic and anionic phospholipid monolayers. Kaznessis, Y.N., Kim, S., Larson, R.G. Biophys. J. (2002) [Pubmed]
  7. Fluorescence light microscopy of pulmonary surfactant at the air-water interface of an air bubble of adjustable size. Knebel, D., Sieber, M., Reichelt, R., Galla, H.J., Amrein, M. Biophys. J. (2002) [Pubmed]
  8. Tumor targeting in vivo by means of thermolabile fusogenic liposomes. Zellmer, S., Cevc, G. Journal of drug targeting. (1996) [Pubmed]
  9. Glucuronate-modified liposomes with prolonged circulation time. Namba, Y., Sakakibara, T., Masada, M., Ito, F., Oku, N. Chem. Pharm. Bull. (1990) [Pubmed]
  10. In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography. Oku, N., Tokudome, Y., Tsukada, H., Kosugi, T., Namba, Y., Okada, S. Biopharmaceutics & drug disposition. (1996) [Pubmed]
  11. Effect of a Dynorphin A analog, E2078, on phospholipid membrane properties. Asai, Y., Watanabe, S. Biol. Pharm. Bull. (1999) [Pubmed]
  12. Leakage and delivery of liposome-encapsulated methotrexate-gamma-aspartate in a chemically defined medium. Comiskey, S.J., Heath, T.D. Biochim. Biophys. Acta (1990) [Pubmed]
  13. Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Lohner, K., Latal, A., Lehrer, R.I., Ganz, T. Biochemistry (1997) [Pubmed]
  14. Metabolism of phosphatidylglycerol by alveolar macrophages in vitro. Quintero, O.A., Wright, J.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2000) [Pubmed]
  15. Quantitation of pulmonary surfactant protein SP-B in the absence or presence of phospholipids by enzyme-linked immunosorbent assay. Oviedo, J.M., Valiño, F., Plasencia, I., Serrano, A.G., Casals, C., Pérez-Gil, J. Anal. Biochem. (2001) [Pubmed]
  16. Thermotropic properties of phosphatidylethanols. Bondar, O.P., Rowe, E.S. Biophys. J. (1996) [Pubmed]
  17. Interactions of thionin from Pyrularia pubera with dipalmitoylphosphatidylglycerol large unilamellar vesicles. Huang, W., Vernon, L.P., Hansen, L.D., Bell, J.D. Biochemistry (1997) [Pubmed]
  18. Sulfhydryl chemistry detects three conformations of the lipid binding region of Escherichia coli pyruvate oxidase. Chang, Y.Y., Cronan, J.E. Biochemistry (1997) [Pubmed]
  19. A theory of effect of protons and divalent cations on phase equilibria in charged bilayer membranes: comparison with experiment. Copeland, B.R., Andersen, H.C. Biochemistry (1982) [Pubmed]
  20. The damage to phospholipids caused by free radical attack on glycerol and sphingosine backbone. Edimecheva, I.P., Kisel, M.A., Shadyro, O.I., Vlasov, A.P., Yurkova, I.L. Int. J. Radiat. Biol. (1997) [Pubmed]
  21. Interaction of lung surfactant proteins with anionic phospholipids. Takamoto, D.Y., Lipp, M.M., von Nahmen, A., Lee, K.Y., Waring, A.J., Zasadzinski, J.A. Biophys. J. (2001) [Pubmed]
  22. Pulmonary surfactant proteins SP-B and SP-C in spread monolayers at the air-water interface: III. Proteins SP-B plus SP-C with phospholipids in spread monolayers. Taneva, S., Keough, K.M. Biophys. J. (1994) [Pubmed]
  23. Kinetic and structural study of the interaction of myelin basic protein with dipalmitoylphosphatidylglycerol layers. Facci, P., Cavatorta, P., Cristofolini, L., Fontana, M.P., Fasano, A., Riccio, P. Biophys. J. (2000) [Pubmed]
  24. Interaction of myelin basic protein with dipalmitoylphosphatidylglycerol: dependence on the lipid phase and investigation of a metastable state. Boggs, J.M., Stamp, D., Moscarello, M.A. Biochemistry (1981) [Pubmed]
  25. A subtransition in a phospholipid with a net charge, dipalmitoylphosphatidylglycerol. Wilkinson, D.A., McIntosh, T.J. Biochemistry (1986) [Pubmed]
  26. Investigation of polylysine-dipalmitoylphosphatidylglycerol interactions in model membranes. Carrier, D., Pézolet, M. Biochemistry (1986) [Pubmed]
  27. Fourier transform infrared studies of secondary structure and orientation of pulmonary surfactant SP-C and its effect on the dynamic surface properties of phospholipids. Pastrana, B., Mautone, A.J., Mendelsohn, R. Biochemistry (1991) [Pubmed]
  28. New ordered metastable phases between the gel and subgel phases in hydrated phospholipids. Tenchov, B., Koynova, R., Rapp, G. Biophys. J. (2001) [Pubmed]
  29. Effect of freezing rate on the stability of liposomes during freeze-drying and rehydration. van Winden, E.C., Zhang, W., Crommelin, D.J. Pharm. Res. (1997) [Pubmed]
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