Disease relevance of Hydroxyanthraquinone

• Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms [1].
• A rat model for human ulcerative colitis (UC) has been developed by using 1-hydroxyanthraquinone (1-HA) to cause severe inflammation of colonic mucosa [2].
• Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone [3].
• Modulation of P450 by emodin may be an important factor affecting metabolism and toxicity of the hydroxyanthraquinone in humans [4].
• The aim of our study was to clarify the apoptosis pathway induced by aloe emodin, an hydroxyanthraquinone present in aloe vera leaves, in rat hepatic stellate cells transformed by simian virus 40 (t-HSC/Cl-6), which retain the features of activated rat stellate cells [5].

High impact information on Hydroxyanthraquinone

• Here we report that aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity [6].
• Expression of cytokines, TNF-alpha and IL-1 alpha, in MAM acetate and 1-hydroxyanthraquinone-induced colon carcinogenesis of rats [7].
• Cell kinetic analysis of the mucosal epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats [8].
• With computer simulation predicting separation in reversed-phase gradient elution, a method to separate and determine five hydroxyanthraquinone derivatives having a wide range of polarity in extract of Chinese herbal medicine rhubarb has been developed [9].
• Seawater samples contained ANT at levels ranging from < 0.2 to 4.7 ng/L, ATQ from 3.9 to 200 ng/L, 1-hydroxyanthraquinone (1-hATQ) from < 0.9 to 5.3 ng/L, and 2-hATQ from 1.6 to 5.5 ng/L [10].

Biological context of Hydroxyanthraquinone

• Cell kinetics and activity of ornithine decarboxylase (ODC) were studied during the process of 1-hydroxyanthraquinone (1-HA)-induced intestinal carcinogenesis in rats [8].
• Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones [11].
• Seasonal variations of hydroxyanthraquinone content of cultivated Cassia spectabilis DC [12].

Gene context of Hydroxyanthraquinone

• The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone [13].

Analytical, diagnostic and therapeutic context of Hydroxyanthraquinone

• Hydroxyanthraquinone dye solutions for radiation dosimetry [14].

References