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Chemical Compound Review

CHEMBL501834     1-hydroxyanthracene-9,10-dione

Synonyms: SureCN145303, CPD-3301, NSC-8640, ACMC-1BT7T, CCRIS 3694, ...
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Disease relevance of Hydroxyanthraquinone


High impact information on Hydroxyanthraquinone


Biological context of Hydroxyanthraquinone


Gene context of Hydroxyanthraquinone


Analytical, diagnostic and therapeutic context of Hydroxyanthraquinone


  1. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Mori, H., Yoshimi, N., Iwata, H., Mori, Y., Hara, A., Tanaka, T., Kawai, K. Carcinogenesis (1990) [Pubmed]
  2. No involvement of APC gene mutations in ulcerative colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate. Suzui, M., Ushijima, T., Yoshimi, N., Nakagama, H., Hara, A., Sugimura, T., Nagao, M., Mori, H. Mol. Carcinog. (1997) [Pubmed]
  3. Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Suzui, M., Ushijima, T., Dashwood, R.H., Yoshimi, N., Sugimura, T., Mori, H., Nagao, M. Mol. Carcinog. (1999) [Pubmed]
  4. Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. Wang, H.W., Chen, T.L., Yang, P.C., Ueng, T.H. Drug Metab. Dispos. (2001) [Pubmed]
  5. Aloe emodin-induced apoptosis in t-HSC/Cl-6 cells involves a mitochondria-mediated pathway. Lian, L.H., Park, E.J., Piao, H.S., Zhao, Y.Z., Sohn, D.H. Basic & clinical pharmacology & toxicology. (2005) [Pubmed]
  6. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Pecere, T., Gazzola, M.V., Mucignat, C., Parolin, C., Vecchia, F.D., Cavaggioni, A., Basso, G., Diaspro, A., Salvato, B., Carli, M., Palù, G. Cancer Res. (2000) [Pubmed]
  7. Expression of cytokines, TNF-alpha and IL-1 alpha, in MAM acetate and 1-hydroxyanthraquinone-induced colon carcinogenesis of rats. Yoshimi, N., Sato, S., Makita, H., Wang, A., Hirose, Y., Tanaka, T., Mori, H. Carcinogenesis (1994) [Pubmed]
  8. Cell kinetic analysis of the mucosal epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats. Mori, H., Mori, Y., Tanaka, T., Yoshimi, N., Sugie, S., Kawamori, T., Narisawa, T. Carcinogenesis (1992) [Pubmed]
  9. Computer-aided development of a high-performance liquid chromatographic method for the determination of hydroxyanthraquinone derivatives in Chinese herb medicine rhubarb. Liu, C.L., Zhu, P.L., Liu, M.C. Journal of chromatography. A. (1999) [Pubmed]
  10. Presence and estrogenicity of anthracene derivatives in coastal Japanese waters. Kurihara, R., Shiraishi, F., Tanaka, N., Hashimoto, S. Environ. Toxicol. Chem. (2005) [Pubmed]
  11. Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones. Kawai, K., Mori, H., Sugie, S., Yoshimi, N., Inoue, T., Nakamaru, T., Nozawa, Y., Matsushima, T. Cell Biol. Toxicol. (1986) [Pubmed]
  12. Seasonal variations of hydroxyanthraquinone content of cultivated Cassia spectabilis DC. Abo, K.A., Adeyemi, A.A., Sobowale, A.O. African journal of medicine and medical sciences. (2000) [Pubmed]
  13. The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone. Yoshimi, N., Ino, N., Suzui, M., Tanaka, T., Nakashima, S., Nakamura, M., Nozawa, Y., Mori, H. Cancer Lett. (1995) [Pubmed]
  14. Hydroxyanthraquinone dye solutions for radiation dosimetry. Bedear El-Assy, N., Alian, A., Abdel Rahim, F., Roushdy, H. The International journal of applied radiation and isotopes. (1982) [Pubmed]
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