High impact information on Ion Channel Gating

• The mechanisms by which glycine acts on NMDA receptors are unknown, but single-channel recording experiments show an increase in opening frequency with no change in mean open time or conductance, suggesting that glycine could regulate transitions to states that are intermediate between binding of NMDA receptor agonists and ion-channel gating [1].
• Simulations suggest that aniracetam either slows entry into a desensitized state or decreases the closing rate constant for ion channel gating [2].
• The molecular events controlling glutamate receptor ion channel gating are complex [3].
• We have identified a methionine residue (Met(823)) in the M4 domain of the NR2A subunit that regulates desensitization and ion channel gating [4].
• Although ethanol is known to inhibit NMDA receptors by influencing ion-channel gating, its molecular site of action and the mechanism underlying this effect have not been established [5].

Biological context of Ion Channel Gating

• An amino-acid substitution in the influenza-B NB protein affects ion-channel gating [6].
• Analysis of fractal ion channel gating kinetics: kinetic rates, energy levels, and activation energies [7].

Associations of Ion Channel Gating with chemical compounds

• A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating [4].
• A statistical comparison is presented of Markov and fractal models of ion channel gating [8].
• Site-specific mutations of nicotinic acetylcholine receptor at the lipid-protein interface dramatically alter ion channel gating [9].
• A recent tryptophan scanning of the alpha-TM3 domain of the Torpedo californica AChR demonstrated that this domain can modulate ion-channel gating [Guzman, G., Santiago, J., Ricardo, A., Martí-Arbona, R., Rojas, L., Lasalde-Dominicci, J. (2003) Biochemistry 42, 12243-12250] [10].
• The role of cystic fibrosis transmembrane conductance regulator phenylalanine 508 side chain in ion channel gating [11].

Gene context of Ion Channel Gating

• Alcohol inhibits NMDA receptor current by an action on ion channel gating, apparently through a direct action on a region of the NMDA receptor accessible from the extracellular environment [12].
• As in other adenine nucleotide binding cassette (ABC) proteins the nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator (CFTR) bind and hydrolyze ATP and in some manner regulate CFTR ion channel gating [13].
• Ion-channel gating. Twist to open [14].
• Their positions relative to one another and to the expected sites of an agonist-induced conformational change suggest that ion channel gating and desensitization may involve more subtle and complex mechanisms than have been assumed based on the structural homology to the PBP [15].
• The classical K+ channel blocker 4-aminopyridine (4-AP), the naturally occurring monoamine serotonin (5-hydroxytryptamine, 5-HT) and its agonist, quipazine, as well as the Ca++ dependent K+ channel blocker quinidine were chosen for investigation based on their known ion channel gating properties [16].

References