Gene Review:
GRIN2A - glutamate receptor, ionotropic, N-methyl D...
Homo sapiens
Synonyms:
EPND, FESD, GluN2A, Glutamate receptor ionotropic, NMDA 2A, LKS, ...
Dambinova,
Khounteev,
Izykenova,
Zavolokov,
Ilyukhina,
Skoromets,
Dalmau,
Tüzün,
Wu,
Masjuan,
Rossi,
Voloschin,
Baehring,
Shimazaki,
Koide,
King,
Mason,
Sansing,
Dichter,
Rosenfeld,
Lynch,
Zalewska,
Ziemka-Nałecz,
Domańska-Janik,
Zheng,
Gingrich,
Traynelis,
Conn,
Wollmuth,
Kuner,
Sakmann,
Barria,
Malinow,
Conti,
Barbaresi,
Melone,
Ducati,
Andresen,
Gay??n,
Cherny,
Brocklebank,
Alkorta-Aranburu,
Addis,
Cardon,
Housman,
Wexler,
- Distribution of the N-methyl-D-aspartate glutamate receptor subunit NR2A in control and amyotrophic lateral sclerosis spinal cord. Samarasinghe, S., Virgo, L., de Belleroche, J. Brain Res. (1996)
- Expression of N-methyl-D-aspartate receptors using vaccinia virus causes excitotoxic death in human kidney cells. García-Gallo, M., Behrens, M.M., Renart, J., Díaz-Guerra, M. J. Cell. Biochem. (1999)
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Dalmau, J., Tüzün, E., Wu, H.Y., Masjuan, J., Rossi, J.E., Voloschin, A., Baehring, J.M., Shimazaki, H., Koide, R., King, D., Mason, W., Sansing, L.H., Dichter, M.A., Rosenfeld, M.R., Lynch, D.R. Ann. Neurol. (2007)
- Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Dambinova, S.A., Khounteev, G.A., Izykenova, G.A., Zavolokov, I.G., Ilyukhina, A.Y., Skoromets, A.A. Clin. Chem. (2003)
- Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region. Adams, J., Crosbie, J., Wigg, K., Ickowicz, A., Pathare, T., Roberts, W., Malone, M., Schachar, R., Tannock, R., Kennedy, J.L., Barr, C.L. Mol. Psychiatry (2004)
- Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds. Andresen, J.M., Gay??n, J., Cherny, S.S., Brocklebank, D., Alkorta-Aranburu, G., Addis, E.A., Cardon, L.R., Housman, D.E., Wexler, N.S. J. Med. Genet. (2007)
- N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease. Bi, H., Sze, C.I. J. Neurol. Sci. (2002)
- Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans. Itokawa, M., Yamada, K., Iwayama-Shigeno, Y., Ishitsuka, Y., Detera-Wadleigh, S., Yoshikawa, T. Neurosci. Lett. (2003)
- Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. van Zundert, B., Yoshii, A., Constantine-Paton, M. Trends Neurosci. (2004)
- Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Choi, Y.B., Tenneti, L., Le, D.A., Ortiz, J., Bai, G., Chen, H.S., Lipton, S.A. Nat. Neurosci. (2000)
- Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Zheng, F., Gingrich, M.B., Traynelis, S.F., Conn, P.J. Nat. Neurosci. (1998)
- NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Barria, A., Malinow, R. Neuron (2005)
- Glycine-independent NMDA receptor desensitization: localization of structural determinants. Villarroel, A., Regalado, M.P., Lerma, J. Neuron (1998)
- Transient forebrain ischemia effects interaction of Src, FAK, and PYK2 with the NR2B subunit of N-methyl-D-aspartate receptor in gerbil hippocampus. Zalewska, T., Ziemka-Nałecz, M., Domańska-Janik, K. Brain Res. (2005)
- Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Turic, D., Langley, K., Mills, S., Stephens, M., Lawson, D., Govan, C., Williams, N., Van Den Bree, M., Craddock, N., Kent, L., Owen, M., O'Donovan, M., Thapar, A. Mol. Psychiatry (2004)
- A microsatellite repeat in the promoter of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene suppresses transcriptional activity and correlates with chronic outcome in schizophrenia. Itokawa, M., Yamada, K., Yoshitsugu, K., Toyota, T., Suga, T., Ohba, H., Watanabe, A., Hattori, E., Shimizu, H., Kumakura, T., Ebihara, M., Meerabux, J.M., Toru, M., Yoshikawa, T. Pharmacogenetics (2003)
- Neuronal and glial localization of NR1 and NR2A/B subunits of the NMDA receptor in the human cerebral cortex. Conti, F., Barbaresi, P., Melone, M., Ducati, A. Cereb. Cortex (1999)
- Cloning, functional coexpression, and pharmacological characterisation of human cDNAs encoding NMDA receptor NR1 and NR2A subunits. Le Bourdellès, B., Wafford, K.A., Kemp, J.A., Marshall, G., Bain, C., Wilcox, A.S., Sikela, J.M., Whiting, P.J. J. Neurochem. (1994)
- Development of N-methyl-D-aspartate receptor subunit immunoreactivity in the neonatal gerbil cochlear nucleus. Joelson, D., Schwartz, I.R. Microsc. Res. Tech. (1998)
- Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. Iwayama, Y., Hashimoto, K., Nakajima, M., Toyota, T., Yamada, K., Shimizu, E., Itokawa, M., Hoshika, A., Iyo, M., Yoshikawa, T. Neurosci. Lett. (2006)
- Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors. Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P.H., Betz, H., Mohler, H. J. Biol. Chem. (1998)
- Intersubunit cooperativity in the NMDA receptor. Regalado, M.P., Villarroel, A., Lerma, J. Neuron (2001)
- Dual role of CaMKII-dependent SAP97 phosphorylation in mediating trafficking and insertion of NMDA receptor subunit NR2A. Mauceri, D., Gardoni, F., Marcello, E., Di Luca, M. J. Neurochem. (2007)
- The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors. Klein, R.C., Prorok, M., Galdzicki, Z., Castellino, F.J. J. Biol. Chem. (2001)
- The alterations of N-Methyl-D-aspartate receptor expressions and oxidative DNA damage in the CA1 area at the early time after ischemia-reperfusion insult. Won, M.H., Kang, T., Park, S., Jeon, G., Kim, Y., Seo, J.H., Choi, E., Chung, M., Cho, S.S. Neurosci. Lett. (2001)
- Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Mathern, G.W., Pretorius, J.K., Mendoza, D., Leite, J.P., Chimelli, L., Born, D.E., Fried, I., Assirati, J.A., Ojemann, G.A., Adelson, P.D., Cahan, L.D., Kornblum, H.I. Ann. Neurol. (1999)
- Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus). Kuramoto, T., Maihara, T., Masu, M., Nakanishi, S., Serikawa, T. Genomics (1994)
- Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia. Iwayama-Shigeno, Y., Yamada, K., Itokawa, M., Toyota, T., Meerabux, J.M., Minabe, Y., Mori, N., Inada, T., Yoshikawa, T. Neurosci. Lett. (2005)
- Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. Hawkins, L.M., Chazot, P.L., Stephenson, F.A. J. Biol. Chem. (1999)
- Intracellular Mg2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel. Wollmuth, L.P., Kuner, T., Sakmann, B. J. Physiol. (Lond.) (1998)
- Identification of molecular determinants that are important in the assembly of N-methyl-D-aspartate receptors. Meddows, E., Le Bourdelles, B., Grimwood, S., Wafford, K., Sandhu, S., Whiting, P., McIlhinney, R.A. J. Biol. Chem. (2001)
- Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease. Hynd, M.R., Scott, H.L., Dodd, P.R. J. Neurochem. (2004)