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Gene Review

Mst1r  -  macrophage stimulating 1 receptor (c-met...

Mus musculus

Synonyms: CD136, CDw136, Fv-2, Fv2, MSP receptor, ...
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Disease relevance of Mst1r


High impact information on Mst1r

  • Fv2 encodes a truncated form of the Stk receptor tyrosine kinase [4].
  • We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk) [4].
  • The Fv-2 genotype of erythroid progenitors directly determines whether they will undergo viral-induced transformation [3].
  • We suggest that the observed skewing in composition among the various mature blood cell types in C57BL/6 in equilibrium DBA/2 allophenic mice is caused by allelic variants of the Stk gene [5].
  • For the effect on the S phase fraction of CFU-S, we refer to the gene(s) as Stk (stem cell kinetics) [5].

Chemical compound and disease context of Mst1r


Biological context of Mst1r

  • Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury [1].
  • Construction of a D2.B6-Fv-2r congenic mouse strain: nonlethality of the homozygous Fv-2' genotype [8].
  • A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells [2].
  • The gene Rv-2, which controls susceptibility to spleen focus formation, was assigned to chromosome 9, and closely linked to the Fv-2 gene, by using the two congenic strains B10.C(47N)/Sn and B6.C-H-7b/By [9].
  • The allelic difference of Fv-2 had no significant effect on the proportion of other progenitor or stem cells (CFU-E, CFU-C or CFU-S) normally undergoing DNA synthesis in the hemopoietic tissues, or on the hemoglobin concentration, red blood cells, hematocrit, total of differential white blood cell counts in the peripheral blood of these animals [10].

Anatomical context of Mst1r


Associations of Mst1r with chemical compounds

  • To examine the role of Mst1r in ALI in more detail, we compared the gene expression profiles of murine lung mRNA from control and Mst1r TK-/- mice at baseline and after 24 h of particulate Ni sulfate exposure [1].
  • Fv2 has recently been shown to encode a truncated form of the Stk receptor tyrosine kinase (Sf-Stk) [2].
  • The scatter response of the 293-Ron cells was also attenuated by treatment of the cells with the specific EGFR inhibitor AG 1478 [13].
  • These results indicate that both gp55 and Epo stimulate EpoR and that the Fv-2 gene encodes a protein that controls response to these ligands [14].
  • The targeted deletion of the cytoplasmic domain of the Ron receptor tyrosine kinase (TK) in mice leads to exaggerated responses to injury in several murine models of inflammation as well as increased lethality in response to endotoxin (lipopolysaccharide [LPS]) [7].

Regulatory relationships of Mst1r

  • Fv2 has also been implicated in the control of cell cycling in early erythroid progenitors (erythroid blast-forming units [BFU-Es]) [2].
  • In addition, we show that the Kit+ pathogenic targets of Friend virus in the spleen are distinct from the pathogenic targets in bone marrow and this population of spleen target cells is markedly decreased in W/W(v) mice and these cells fail to express Sf-Stk [15].
  • We report that Ron mRNA is expressed by NGF-dependent sensory and sympathetic neurons and that these neurons survive and grow with MSP at different stages of development [16].

Other interactions of Mst1r


Analytical, diagnostic and therapeutic context of Mst1r


  1. Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury. Mallakin, A., Kutcher, L.W., McDowell, S.A., Kong, S., Schuster, R., Lentsch, A.B., Aronow, B.J., Leikauf, G.D., Waltz, S.E. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  2. A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. Melkun, E., Pilione, M., Paulson, R.F. Blood (2002) [Pubmed]
  3. Cellular site and mode of Fv-2 gene action. Behringer, R.R., Dewey, M.J. Cell (1985) [Pubmed]
  4. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Persons, D.A., Paulson, R.F., Loyd, M.R., Herley, M.T., Bodner, S.M., Bernstein, A., Correll, P.H., Ney, P.A. Nat. Genet. (1999) [Pubmed]
  5. Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide. Van Zant, G., Eldridge, P.W., Behringer, R.R., Dewey, M.J. Cell (1983) [Pubmed]
  6. Friend spleen focus-forming virus transforms rodent fibroblasts in cooperation with a short form of the receptor tyrosine kinase Stk. Nishigaki, K., Hanson, C., Jelacic, T., Thompson, D., Ruscetti, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure. Leonis, M.A., Toney-Earley, K., Degen, S.J., Waltz, S.E. Hepatology (2002) [Pubmed]
  8. Construction of a D2.B6-Fv-2r congenic mouse strain: nonlethality of the homozygous Fv-2' genotype. Dizik, M., Elliott, R.W., Lilly, F. J. Natl. Cancer Inst. (1981) [Pubmed]
  9. Chromosomal assignment of two murine genes controlling susceptibility to spleen focus formation by Rauscher leukemia virus. Heller, E., Pluznik, D.H. Exp. Hematol. (1984) [Pubmed]
  10. Fv-2 locus controls the proportion of erythropoietic progenitor cells (BFU-E) synthesizing DNA in normal mice. Suzuki, S., Axelrad, A.A. Cell (1980) [Pubmed]
  11. Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein results in the induction of arginase activity in murine peritoneal macrophages. Morrison, A.C., Correll, P.H. J. Immunol. (2002) [Pubmed]
  12. The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse. Muraoka, R.S., Sun, W.Y., Colbert, M.C., Waltz, S.E., Witte, D.P., Degen, J.L., Friezner Degen, S.J. J. Clin. Invest. (1999) [Pubmed]
  13. Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. Peace, B.E., Hill, K.J., Degen, S.J., Waltz, S.E. Exp. Cell Res. (2003) [Pubmed]
  14. Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene. Hoatlin, M.E., Kozak, S.L., Lilly, F., Chakraborti, A., Kozak, C.A., Kabat, D. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  15. Resistance to friend virus-induced erythroleukemia in W/W(v) mice is caused by a spleen-specific defect which results in a severe reduction in target cells and a lack of Sf-Stk expression. Subramanian, A., Teal, H.E., Correll, P.H., Paulson, R.F. J. Virol. (2005) [Pubmed]
  16. Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons. Forgie, A., Wyatt, S., Correll, P.H., Davies, A.M. Development (2003) [Pubmed]
  17. Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide. Morrison, A.C., Wilson, C.B., Ray, M., Correll, P.H. J. Immunol. (2004) [Pubmed]
  18. Cross-talk between the proto-oncogenes Met and Ron. Follenzi, A., Bakovic, S., Gual, P., Stella, M.C., Longati, P., Comoglio, P.M. Oncogene (2000) [Pubmed]
  19. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Ni, S., Zhao, C., Feng, G.S., Paulson, R.F., Correll, P.H. Mol. Cell. Biol. (2007) [Pubmed]
  20. Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Iwama, A., Okano, K., Sudo, T., Matsuda, Y., Suda, T. Blood (1994) [Pubmed]
  21. Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system. Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N., Suda, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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