Disease relevance of Hearing Disorders

• Prevalence of COCH mutations worldwide is unknown, as there is no systematic screening effort for late-onset hearing disorders; however, to date, COCH mutations have been found on four continents and the possibility of COCH playing an important role in presbycusis and disorders of imbalance has been considered [1].
• The standard treatment for many hearing disorders is glucocorticoid therapy, although the cochlear mechanisms involved in steroid-responsive hearing loss are poorly understood [2].
• The study has investigated the relationship between the chromosomal aberration and ear and/or hearing disorders in 115 girls/women with Turner syndrome (TS) [3].
• Nonsyndromic low-frequency sensorineural hearing loss (LFSNHL) comprises a group (DFNA1, DFNA6, DFNA14, and DFNA38) of hearing disorders affecting only frequencies below 2000 Hz, and is often associated with tinnitus [4].
• These positive results suggest the autoimmune mouse may be useful for studies of steroid-responsive mechanisms of the cochlea in autoimmune sensorineural hearing loss, as well as any hearing disorder in which steroid therapy is currently used [5].

High impact information on Hearing Disorders

• Such hearing disorders are often permanent and can be caused by therapeutic agents, such as aminoglycoside antibiotics and cisplatin, or by aging, loud sounds, infections and mechanical injury (1) [6].
• A third group, including Coch-5B2 and an ear-specific connexin, comprises proteins whose human equivalents are candidates to account for hearing disorders [7].
• The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging [8].
• For the group that failed at 30 dB hearing level, 80% of those who were abnormal at follow-up were considered to have conductive hearing disorders and 20% had mild sensorineural hearing impairments [9].
• No obvious morphological abnormalities were detected in Klotho mice, although no expression of Klotho protein was detected, and there was an apparent hearing disorder [10].

Chemical compound and disease context of Hearing Disorders

• In study 1, of 8,333 children examined for hearing disorders, 134 (1.6%) had received previous treatment with gentamicin [11].

Biological context of Hearing Disorders

• OBJECTIVES/HYPOTHESIS: Auditory neuropathy is a sensorineural hearing disorder characterized by absent or abnormal auditory brainstem responses and normal cochlear outer hair cell function as measured by otoacoustic emission recordings [12].

Anatomical context of Hearing Disorders

• The expression and localization of COL2A1 mRNA and protein was examined in human fetal cochlea to study the role of this gene in hearing and to begin to understand the pathogenesis of mutations in COL2A1 in hearing disorders [13].
• Evidence of serum antibodies against inner ear tissues in the blood of patients with certain sensorineural hearing disorders [14].
• In normal mice, ADM is extruded by p-gp from the inner ear and auditory pathway, thus preventing hearing disorder [15].

Gene context of Hearing Disorders

• Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study [16].
• Recreational noise exposure and its effects on the hearing of adolescents. Part II: development of hearing disorders [17].
• Ear and hearing disorders in rural grade 2 (Sub B) schoolchildren in the western Cape [18].
• In combination with caloric testing, ABR is considered a valuable testing procedure in the audiological clinic and it may form the basis for submission to brain imaging examination when a suspicion of retrocochlear hearing disorder is raised [19].
• Eighteen patients with low-frequency hearing loss ( LFHL ), 10 males and 8 females with an average age of 27 years, were examined in order to classify their hearing loss, i.e. to find the topical site of the hearing lesion and to evaluate the aetiology of the hearing disorder [20].

Analytical, diagnostic and therapeutic context of Hearing Disorders

• OBJECTIVE: The purpose of this study was to determine the etiology of bilateral sensorineural hearing disorders in children and to evaluate the performed hearing tests by comparison of the results of the objective and subjective tests [21].

References