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MeSH Review

Hearing Disorders

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Disease relevance of Hearing Disorders


High impact information on Hearing Disorders

  • Such hearing disorders are often permanent and can be caused by therapeutic agents, such as aminoglycoside antibiotics and cisplatin, or by aging, loud sounds, infections and mechanical injury (1) [6].
  • A third group, including Coch-5B2 and an ear-specific connexin, comprises proteins whose human equivalents are candidates to account for hearing disorders [7].
  • The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging [8].
  • For the group that failed at 30 dB hearing level, 80% of those who were abnormal at follow-up were considered to have conductive hearing disorders and 20% had mild sensorineural hearing impairments [9].
  • No obvious morphological abnormalities were detected in Klotho mice, although no expression of Klotho protein was detected, and there was an apparent hearing disorder [10].

Chemical compound and disease context of Hearing Disorders


Biological context of Hearing Disorders


Anatomical context of Hearing Disorders


Gene context of Hearing Disorders


Analytical, diagnostic and therapeutic context of Hearing Disorders

  • OBJECTIVE: The purpose of this study was to determine the etiology of bilateral sensorineural hearing disorders in children and to evaluate the performed hearing tests by comparison of the results of the objective and subjective tests [21].


  1. Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction. Robertson, N.G., Cremers, C.W., Huygen, P.L., Ikezono, T., Krastins, B., Kremer, H., Kuo, S.F., Liberman, M.C., Merchant, S.N., Miller, C.E., Nadol, J.B., Sarracino, D.A., Verhagen, W.I., Morton, C.C. Hum. Mol. Genet. (2006) [Pubmed]
  2. Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Trune, D.R., Kempton, J.B., Gross, N.D. Hear. Res. (2006) [Pubmed]
  3. The influence of karyotype on the auricle, otitis media and hearing in Turner syndrome. Barrenäs, M.L., Nylén, O., Hanson, C. Hear. Res. (1999) [Pubmed]
  4. Confirmation of genetic homogeneity of nonsyndromic low-frequency sensorineural hearing loss by linkage analysis and a DFNA6/14 mutation in a Japanese family. Komatsu, K., Nakamura, N., Ghadami, M., Matsumoto, N., Kishino, T., Ohta, T., Niikawa, N., Yoshiura, K. J. Hum. Genet. (2002) [Pubmed]
  5. Steroid-responsive cochlear dysfunction in the MRL/lpr autoimmune mouse. Wobig, R.J., Kempton, J., Trune, D.R. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1999) [Pubmed]
  6. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Ernfors, P., Duan, M.L., ElShamy, W.M., Canlon, B. Nat. Med. (1996) [Pubmed]
  7. Molecular markers for cell types of the inner ear and candidate genes for hearing disorders. Heller, S., Sheane, C.A., Javed, Z., Hudspeth, A.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Bowers, W.J., Chen, X., Guo, H., Frisina, D.R., Federoff, H.J., Frisina, R.D. Mol. Ther. (2002) [Pubmed]
  9. Auditory brainstem responses and clinical follow-up of high-risk infants. Kramer, S.J., Vertes, D.R., Condon, M. Pediatrics (1989) [Pubmed]
  10. Expression of Klotho protein in the inner ear. Kamemori, M., Ohyama, Y., Kurabayashi, M., Takahashi, K., Nagai, R., Furuya, N. Hear. Res. (2002) [Pubmed]
  11. Vestibulotoxicity and ototoxicity of gentamicin in newborns at risk. Aust, G. The international tinnitus journal. (2001) [Pubmed]
  12. Familial auditory neuropathy. Wang, Q., Gu, R., Han, D., Yang, W. Laryngoscope (2003) [Pubmed]
  13. Expression and localization of COL2A1 mRNA and type II collagen in human fetal cochlea. Khetarpal, U., Robertson, N.G., Yoo, T.J., Morton, C.C. Hear. Res. (1994) [Pubmed]
  14. Evidence of serum antibodies against inner ear tissues in the blood of patients with certain sensorineural hearing disorders. Arnold, W., Pfaltz, R., Altermatt, H.J. Acta Otolaryngol. (1985) [Pubmed]
  15. Doxorubicin ototoxicity is induced in mice by combination treatment with cyclosporin A. Saito, T., Zhang, Z.J., Tokuriki, M., Shibamori, Y., Yamamoto, T., Noda, I., Ohtsubo, T., Saito, H. Acta Otolaryngol. (2001) [Pubmed]
  16. Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study. Andonopoulos, A.P., Naxakis, S., Goumas, P., Lygatsikas, C. Clinical and experimental rheumatology. (1995) [Pubmed]
  17. Recreational noise exposure and its effects on the hearing of adolescents. Part II: development of hearing disorders. Biassoni, E.C., Serra, M.R., Richtert, U., Joekes, S., Yacci, M.R., Carignani, J.A., Abraham, S., Minoldo, G., Franco, G. International journal of audiology. (2005) [Pubmed]
  18. Ear and hearing disorders in rural grade 2 (Sub B) schoolchildren in the western Cape. Prescott, C.A., Kibel, M.A. S. Afr. Med. J. (1991) [Pubmed]
  19. Clinical application of brain-stem audiometry. Sørensen, M., Christensen, B., Parving, A. Scandinavian audiology. (1988) [Pubmed]
  20. Inherited low-frequency hearing loss. A new mixed conductive/sensorineural entity? Parving, A. Scandinavian audiology. (1984) [Pubmed]
  21. Bilateral sensorineural hearing disorders in children: etiology of deafness and evaluation of hearing tests. Walch, C., Anderhuber, W., Köle, W., Berghold, A. Int. J. Pediatr. Otorhinolaryngol. (2000) [Pubmed]
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