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MeSH Review

Schistosomiasis mansoni

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Disease relevance of Schistosomiasis mansoni

  • Using an in vitro model of granuloma formation, we have shown that immune complexes (IC) isolated from sera of chronic intestinal schistosomiasis patients were able to reduce granulomatous reaction developed against soluble egg antigen-conjugated polyacrylamide beads [1].
  • Since involvement of IL-1 beta in the pathogenesis of severe granulomatous lesions could not be ruled out, 17 patients with intestinal schistosomiasis and 17 patients with hepatosplenic schistosomiasis were matched for intensity of infection and monitored 3-6 months after praziquantel therapy [2].

High impact information on Schistosomiasis mansoni


Chemical compound and disease context of Schistosomiasis mansoni


Gene context of Schistosomiasis mansoni

  • After anti-schistosomal therapy with praziquantel, mitogen-induced IL-2 and IFN-gamma activities became normal within 3 months in intestinal schistosomiasis, and within 6 months in the hepatosplenic patient group [12].
  • Three months after therapy, IL-1 beta was detectable in serum in an increased proportion of intestinal schistosomiasis patients [2].
  • The paper discusses the implications of these findings for efforts to promote regular treatment with praziquantel of people living in or near the Nile Delta who are at risk for intestinal schistosomiasis [13].


  1. Nitric oxide-mediated immune complex-induced prostaglandin E(2) production by peripheral blood mononuclear cells of humans infected with Schistosoma mansoni. Neves, S.M., Rezende, S.A., Goes, A.M. Cell. Immunol. (1999) [Pubmed]
  2. Altered generation of interleukin 1 in chronic human schistosomiasis mansoni. Zwingenberger, K., Richter, J., Taupitz, S., Vergetti Siqueira, J.G., Correia Dacal, A.R. Scand. J. Immunol. (1990) [Pubmed]
  3. Cytokine production in acute versus chronic human Schistosomiasis mansoni: the cross-regulatory role of interferon-gamma and interleukin-10 in the responses of peripheral blood mononuclear cells and splenocytes to parasite antigens. Montenegro, S.M., Miranda, P., Mahanty, S., Abath, F.G., Teixeira, K.M., Coutinho, E.M., Brinkman, J., Gonçalves, I., Domingues, L.A., Domingues, A.L., Sher, A., Wynn, T.A. J. Infect. Dis. (1999) [Pubmed]
  4. GM-CSF and TNF-alpha synergize to increase in vitro granuloma size of PBMC from humans induced by Schistosoma mansoni recombinant 28-kDa GST. Rezende, C.M., Goes, T.S., Goes, V.S., Azevedo, V., Leite, M.F., Goes, A.M. Immunol. Lett. (2004) [Pubmed]
  5. Down modulation of MHC surface molecules on B cells by suppressive immune complexes obtained from chronic intestinal schistosomiasis patients. Rezende, S.A., Gollob, K.J., Correa-Oliveira, R., Goes, A.M. Immunol. Lett. (1998) [Pubmed]
  6. Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men. Skelly, P.J., Secor, W.E., Reis, M.G., Ramos, E.A., Carmo, T.M., Peixoto, E.E., Harn, D.A. Am. J. Trop. Med. Hyg. (1994) [Pubmed]
  7. Somatostatin and intestinal schistosomiasis: therapeutic and neuropathological implications in host-parasite interactions. Chatterjee, S., De Man, J., Van Marck, E. Trop. Med. Int. Health (2001) [Pubmed]
  8. Cure rates and egg reduction in treatment of intestinal schistosomiasis with oxamniquine and praziquantel in Maniema, Zaire. Polderman, A.M., Gryseels, B., De Caluwe, P. Trans. R. Soc. Trop. Med. Hyg. (1988) [Pubmed]
  9. Chronic human schistosomiasis mansoni-schistosomal antigen, immunoglobulins and complement C3 detection in the liver. De Brito, T., Shimizu, S.H., Yamashiro, E., Da Silva, L.C. Liver (1985) [Pubmed]
  10. Effects of oral contraception on liver function tests and serum proteins in women with active schistosomiasis. Shaaban, M.M., Hammad, W.A., Falthalla, M.F., Ghaneimah, S.A., El-Sharkawy, M.M., Salim, T.H., Liao, W.C., Smith, S.C. Contraception. (1982) [Pubmed]
  11. Evaluation of pilot control trial of intestinal schistosomiasis in the Finchaa Sugar Estate, Ethiopia. Erko, B., Medhin, G., Balcha, F., Raje, S. Ethiop. Med. J. (2003) [Pubmed]
  12. Release of interleukin 2 and gamma interferon by peripheral mononuclear cells in human Schistosoma mansoni infection normalizes after chemotherapy. Zwingenberger, K., Irschick, E., Siqueira Vergetti, J.G., Correia Dacal, A.R., Janssen-Rosseck, R., Bienzle, U., Huber, C., Feldmeier, H. Scand. J. Immunol. (1989) [Pubmed]
  13. Factors affecting knowledge of the symptoms of schistosomiasis in two rural areas near Ismailia, Egypt. Mehanna, S., Winch, P.J., Rizkalla, N.H., el-Sayed, H.F., Abaza, S.M. Trop. Med. Int. Health (1997) [Pubmed]
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