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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, rev

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Disease relevance of Genes, rev


High impact information on Genes, rev

  • Mutation of the rev initiation codon (tat+ rev-) and (tat-rev-) resulted in no detectable expression of env products but expression of these proteins could be rescued by co-transfection of a cDNA encoding the rev gene [4].
  • Nuclear run-on assays revealed an approximately 10-fold increase in the transcriptional rate of the Rev gene during cycloheximide treatment [5].
  • The cycloheximide-induced increase in Rev gene expression was due to inhibition of protein synthesis since anisomycin caused a similar induction of Rev mRNA [5].
  • We hypothesize that this may be causally related to the accumulation of Rev mRNA (or the nascent Rev gene transcript), which could inhibit splicing to alpha 2 by hybridizing to complementary sequences, favoring alpha 1 mRNA production [5].
  • In addition, we show that the SIV rev gene is properly spliced from a single SIV subgenomic DNA fragment and that the Rev protein is expressed in recombinant Ad-SIV-infected human as well as monkey cells [6].

Chemical compound and disease context of Genes, rev


Gene context of Genes, rev

  • Using the rev gene of HIV as a model target, RNase protection assays and cell-free translation arrest showed that the PNA-OX26-SA conjugate maintained active recognition and inactivation of target mRNA, respectively [8].
  • To define the effect of the SIV rev gene on its gp160 expression, two SV40 constructs have been made: pBC17 is a rev+env+ construct, and pBD21 is a rev-env+ construct [9].


  1. Regulation of human immunodeficiency virus env expression by the rev gene product. Hammarskjöld, M.L., Heimer, J., Hammarskjöld, B., Sangwan, I., Albert, L., Rekosh, D. J. Virol. (1989) [Pubmed]
  2. Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K. Löwer, R., Tönjes, R.R., Korbmacher, C., Kurth, R., Löwer, J. J. Virol. (1995) [Pubmed]
  3. Coexpression of biologically active simian immunodeficiency virus (SIV) Rev and Env in an SV40 system: the SIV rev gene regulates env expression. Cheng, S.M., Blume, M., Lee, S.G., Hung, P.P., Hirsch, V.M., Johnson, P.R. Virology (1990) [Pubmed]
  4. Expression of human immunodeficiency virus 1 (HIV-1) envelope gene products transcribed from a heterologous promoter. Kinetics of HIV-1 envelope processing in transfected cells. Bird, C., Burke, J., Gleeson, P.A., McCluskey, J. J. Biol. Chem. (1990) [Pubmed]
  5. Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription. Lazar, M.A., Hodin, R.A., Cardona, G., Chin, W.W. J. Biol. Chem. (1990) [Pubmed]
  6. Coexpression of the simian immunodeficiency virus Env and Rev proteins by a recombinant human adenovirus host range mutant. Cheng, S.M., Lee, S.G., Ronchetti-Blume, M., Virk, K.P., Mizutani, S., Eichberg, J.W., Davis, A., Hung, P.P., Hirsch, V.M., Chanock, R.M. J. Virol. (1992) [Pubmed]
  7. High-performance liquid chromatographic analysis of phosphorothioate analogues of oligodeoxynucleotides in biological fluids. Bigelow, J.C., Chrin, L.R., Mathews, L.A., McCormick, J.J. J. Chromatogr. (1990) [Pubmed]
  8. Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. Boado, R.J., Tsukamoto, H., Pardridge, W.M. Journal of pharmaceutical sciences. (1998) [Pubmed]
  9. The simian immunodeficiency virus (SIV) rev gene regulates env expression. Cheng, S.M., Blume, M., Lee, S.G., Hung, P.P., Hirsch, V.M., Johnson, P.R. J. Med. Primatol. (1990) [Pubmed]
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