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Gene Review

HIV2gp6  -  rev protein

Human immunodeficiency virus 2

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Disease relevance of HIV2gp6


High impact information on HIV2gp6


Chemical compound and disease context of HIV2gp6

  • The human immunodeficiency virus type 1 rev protein binds with high affinity (Kd less than 1-3 nM) to a purine-rich "bubble" containing bulged GG and GUA residues on either side of a double-helical RNA stem-loop located toward the 5' end of rev-response element RNA [9].
  • Specific crosslinking was demonstrated between the Rev protein of HIV-1 (as a glutathione S-transferase fusion protein) and its RNA target, the Rev-responsive element [10].
  • It therefore appears that the Rev protein of EIAV, while analogous in function to Rev proteins defined in lentiviruses of primate, ovine, and caprine origin, is nevertheless distinguished by an entirely novel domain organization [11].
  • Evaluation of stilbene-containing RNA RBE sequences of varying length for their ability to bind the Rev protein of HIV-1 showed that a 22-nucleotide stilbenedicarboxamide conjugate bound Rev almost as well as a 94-base fragment of the Rev Responsive Element (RRE) [12].
  • This leucine-rich stretch of amino acids proved to be essential for the transactivating properties of HIV-1 Rev. Some mutants in the AD transdominantly inhibit the function of wild-type Rev protein very efficiently [13].

Biological context of HIV2gp6


Anatomical context of HIV2gp6


Associations of HIV2gp6 with chemical compounds


Other interactions of HIV2gp6


Analytical, diagnostic and therapeutic context of HIV2gp6


  1. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Zapp, M.L., Stern, S., Green, M.R. Cell (1993) [Pubmed]
  2. Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Yedavalli, V.S., Neuveut, C., Chi, Y.H., Kleiman, L., Jeang, K.T. Cell (2004) [Pubmed]
  3. Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro. Daly, T.J., Cook, K.S., Gray, G.S., Maione, T.E., Rusche, J.R. Nature (1989) [Pubmed]
  4. Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. Malim, M.H., Freimuth, W.W., Liu, J., Boyle, T.J., Lyerly, H.K., Cullen, B.R., Nabel, G.J. J. Exp. Med. (1992) [Pubmed]
  5. Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA. Fischer, U., Meyer, S., Teufel, M., Heckel, C., Lührmann, R., Rautmann, G. EMBO J. (1994) [Pubmed]
  6. Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev. Kjems, J., Frankel, A.D., Sharp, P.A. Cell (1991) [Pubmed]
  7. HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing. Powell, D.M., Amaral, M.C., Wu, J.Y., Maniatis, T., Greene, W.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. Zapp, M.L., Hope, T.J., Parslow, T.G., Green, M.R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs. Heaphy, S., Finch, J.T., Gait, M.J., Karn, J., Singh, M. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Preparation of oligoribonucleotides containing 4-thiouridine using Fpmp chemistry. Photo-crosslinking to RNA binding proteins using 350 nm irradiation. McGregor, A., Rao, M.V., Duckworth, G., Stockley, P.G., Connolly, B.A. Nucleic Acids Res. (1996) [Pubmed]
  11. Identification of the activation domain of equine infectious anemia virus rev. Fridell, R.A., Partin, K.M., Carpenter, S., Cullen, B.R. J. Virol. (1993) [Pubmed]
  12. Incorporation of a non-nucleotide bridge into hairpin oligonucleotides capable of high-affinity binding to the Rev protein of HIV-1. Nelson, J.S., Giver, L., Ellington, A.D., Letsinger, R.L. Biochemistry (1996) [Pubmed]
  13. The activation domain of simian immunodeficiency virus SIVmac239 Rev protein is structurally and functionally analogous to the HIV-1 Rev activation domain. Berchtold, S., Hornung, U., Aepinus, C. Virology (1995) [Pubmed]
  14. PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression. Zolotukhin, A.S., Michalowski, D., Bear, J., Smulevitch, S.V., Traish, A.M., Peng, R., Patton, J., Shatsky, I.N., Felber, B.K. Mol. Cell. Biol. (2003) [Pubmed]
  15. Regulation of HIV-1 gene expression. Cullen, B.R. FASEB J. (1991) [Pubmed]
  16. Intermolecular binding sites of human immunodeficiency virus type 1 Rev protein determined by protein footprinting. Jensen, T.H., Leffers, H., Kjems, J. J. Biol. Chem. (1995) [Pubmed]
  17. Location of the HIV-1 Rev protein during mitosis: inactivation of the nuclear export signal alters the pathway for postmitotic reentry into nucleoli. Dundr, M., Leno, G.H., Lewis, N., Rekosh, D., Hammarskjöid, M.L., Olson, M.O. J. Cell. Sci. (1996) [Pubmed]
  18. Transcomplementation of simian immunodeficiency virus Rev with human T-cell leukemia virus type I Rex. Krohn, K.J., Hakkarainen, K., Aavik, E., Dewhurst, S., Sadaie, R., Mullins, J.I. J. Virol. (1993) [Pubmed]
  19. The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells. Hamaia, S., Cassé, H., Gazzolo, L., Duc Dodon, M. J. Virol. (1997) [Pubmed]
  20. Gene therapy for AIDS using retroviral mediated gene transfer to deliver HIV-1 antisense TAR and transdominant Rev protein genes to syngeneic lymphocytes in HIV-1 infected identical twins. Morgan, R.A., Walker, R. Hum. Gene Ther. (1996) [Pubmed]
  21. Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. Clawson, G.A., Song, Y.L., Schwartz, A.M., Shukla, R.R., Patel, S.G., Connor, L., Blankenship, L., Hatem, C., Kumar, A. Cell Growth Differ. (1991) [Pubmed]
  22. Subcellular localization of rev-gene product in visna virus-infected cells. Mazarin, V., Gourdou, I., Querat, G., Sauze, N., Audoly, G., Vitu, C., Russo, P., Rousselot, C., Filippi, P., Vigne, R. Virology (1990) [Pubmed]
  23. Exchange of the basic domain of human immunodeficiency virus type 1 Rev for a polyarginine stretch expands the RNA binding specificity, and a minimal arginine cluster is required for optimal RRE RNA binding affinity, nuclear accumulation, and trans-activation. Nam, Y.S., Petrovic, A., Jeong, K.S., Venkatesan, S. J. Virol. (2001) [Pubmed]
  24. Phosphorylation of the rev gene product of human immunodeficiency virus type 1. Hauber, J., Bouvier, M., Malim, M.H., Cullen, B.R. J. Virol. (1988) [Pubmed]
  25. Dynamics of RNA-protein interactions in the HIV-1 Rev-RRE complex visualized by 6-thioguanosine-mediated photocrosslinking. Ping, Y.H., Liu, Y., Wang, X., Neenhold, H.R., Rana, T.M. RNA (1997) [Pubmed]
  26. Quantitative study of the control of HIV-1 gene expression. Hammond, B.J. J. Theor. Biol. (1993) [Pubmed]
  27. Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA. Daefler, S., Klotman, M.E., Wong-Staal, F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. Purification and characterization of recombinant Rev protein of human immunodeficiency virus type 1. Nalin, C.M., Purcell, R.D., Antelman, D., Mueller, D., Tomchak, L., Wegrzynski, B., McCarney, E., Toome, V., Kramer, R., Hsu, M.C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  29. The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein. Dundr, M., Leno, G.H., Hammarskjöld, M.L., Rekosh, D., Helga-Maria, C., Olson, M.O. J. Cell. Sci. (1995) [Pubmed]
  30. Selection and characterization of human immunodeficiency virus type 1 mutants that are resistant to inhibition by the transdominant negative RevM10 protein. Hamm, T.E., Rekosh, D., Hammarskjöld, M.L. J. Virol. (1999) [Pubmed]
  31. Influenza B and C virus NEP (NS2) proteins possess nuclear export activities. Paragas, J., Talon, J., O'Neill, R.E., Anderson, D.K., García-Sastre, A., Palese, P. J. Virol. (2001) [Pubmed]
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