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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ileal Diseases

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Disease relevance of Ileal Diseases


High impact information on Ileal Diseases

  • RESULTS: We show that NOD2/CARD15 mutations determine ileal disease only [5].
  • Biliary bilirubin concentrations correlated positively with the anatomic length and duration of ileal disease [6].
  • Multivariate model predicts that the probability of symptomatic relapse significantly decreases with mesalamine treatment, by increasing proportion of patients with ileal disease, with prolonged disease duration, and with surgically induced remission [7].
  • The results suggested that the hyperabsorption of oxalate in ileal disease cannot be accounted for solely by an increased absorbable oxalate pool associated with calcium-fatty acid complexation [8].
  • In CD, we found a negative association between ileal disease involvement and TLR1 S602I (P = .03, OR [95% CI] 0.522 [0.286-0.950]) [9].

Chemical compound and disease context of Ileal Diseases


Gene context of Ileal Diseases

  • We show a significant association of ileal involvement with CARD15 variants (OR = 1.8; p = 0.02), HLA-DRB1*0701 (OR = 1.9; p = 0.006) and DRB1*04 (OR = 1.7; p = 0.02) alleles and demonstrate the capacity of combined CARD15 and HLA-DRB1 genotyping to predict ileal disease in CD patients [12].
  • CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients [13].
  • Ileal disease associated with spinal irradiation for ankylosing spondylitis [14].
  • There are some notable epidemiological and phenotypic differences between Chinese CD with Caucasian CD including the lack of familial clustering, male predominance, and higher proportion of upper GIT involvement and lower frequency of isolated terminal ileal disease [15].
  • Ileal disease was found to have a significant influence on the Delta IgG of ASCA (P = 0.032) [16].

Analytical, diagnostic and therapeutic context of Ileal Diseases

  • The increase was more prominent and sustained in those with ileal disease (ileal resection or jujunoileal bypass); thus, 35 per cent of the orally administered oxalate eventually appeared in the urine in the group with ileal disease, 8 per cent in the group with stones (renal and absorptive hypercalciurias) and 9 per cent in the control group [8].


  1. CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Vermeire, S., Wild, G., Kocher, K., Cousineau, J., Dufresne, L., Bitton, A., Langelier, D., Pare, P., Lapointe, G., Cohen, A., Daly, M.J., Rioux, J.D. Am. J. Hum. Genet. (2002) [Pubmed]
  2. Bile composition in inflammatory bowel disease: ileal disease and colectomy, but not colitis, induce lithogenic bile. Pereira, S.P., Bain, I.M., Kumar, D., Dowling, R.H. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  3. Bacterial overgrowth in jejunal and ileal disease. Bjørneklett, A., Fausa, O., Midtvedt, T. Scand. J. Gastroenterol. (1983) [Pubmed]
  4. Urinary patterns of patients with renal stones associated with chronic inflammatory bowel disease. Trinchieri, A., Lizzano, R., Castelnuovo, C., Zanetti, G., Pisani, E. Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia. (2002) [Pubmed]
  5. The molecular classification of the clinical manifestations of Crohn's disease. Ahmad, T., Armuzzi, A., Bunce, M., Mulcahy-Hawes, K., Marshall, S.E., Orchard, T.R., Crawshaw, J., Large, O., de Silva, A., Cook, J.T., Barnardo, M., Cullen, S., Welsh, K.I., Jewell, D.P. Gastroenterology (2002) [Pubmed]
  6. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease. Brink, M.A., Slors, J.F., Keulemans, Y.C., Mok, K.S., De Waart, D.R., Carey, M.C., Groen, A.K., Tytgat, G.N. Gastroenterology (1999) [Pubmed]
  7. Mesalamine in the maintenance treatment of Crohn's disease: a meta-analysis adjusted for confounding variables. Cammà, C., Giunta, M., Rosselli, M., Cottone, M. Gastroenterology (1997) [Pubmed]
  8. Renal oxalate excretion following oral oxalate loads in patients with ileal disease and with renal and absorptive hypercalciurias. Effect of calcium and magnesium. Barilla, D.E., Notz, C., Kennedy, D., Pak, C.Y. Am. J. Med. (1978) [Pubmed]
  9. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. Pierik, M., Joossens, S., Van Steen, K., Van Schuerbeek, N., Vlietinck, R., Rutgeerts, P., Vermeire, S. Inflamm. Bowel Dis. (2006) [Pubmed]
  10. The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Rhodes, J.M., Middleton, P., Jewell, D.P. Scand. J. Gastroenterol. (1979) [Pubmed]
  11. Gallbladder bile composition in patients with Crohn 's disease. Lapidus, A., Akerlund, J.E., Einarsson, C. World J. Gastroenterol. (2006) [Pubmed]
  12. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Newman, B., Silverberg, M.S., Gu, X., Zhang, Q., Lazaro, A., Steinhart, A.H., Greenberg, G.R., Griffiths, A.M., McLeod, R.S., Cohen, Z., Fernández-Viña, M., Amos, C.I., Siminovitch, K. Am. J. Gastroenterol. (2004) [Pubmed]
  13. Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations. Lakatos, P.L., Lakatos, L., Szalay, F., Willheim-Polli, C., Osterreicher, C., Tulassay, Z., Molnar, T., Reinisch, W., Papp, J., Mozsik, G., Ferenci, P. World J. Gastroenterol. (2005) [Pubmed]
  14. Ileal disease associated with spinal irradiation for ankylosing spondylitis. Palmer, K.R., Willson, S.A., Palmer, J., Brew, D.S., Ball, P.A., Bamji, A. Am. J. Gastroenterol. (1983) [Pubmed]
  15. The epidemiology and phenotype of Crohn's disease in the Chinese population. Leong, R.W., Lau, J.Y., Sung, J.J. Inflamm. Bowel Dis. (2004) [Pubmed]
  16. Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn's patients and are not inducible in murine models of colitis. Müller, S., Styner, M., Seibold-Schmid, B., Flogerzi, B., Mähler, M., Konrad, A., Seibold, F. World J. Gastroenterol. (2005) [Pubmed]
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