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MeSH Review:

Genes, Intracisternal A-Particle

Xiao, G.H. et al., Hirsch, H.H. et al., Greenberg, R. et al., Lueders, K.K., Fehrmann, F. et al., et al.

Gwynn, Lueders, Sands, Birkenmeier,

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High impact information on Genes, Intracisternal A-Particle

For one tumor, the insertion was shown to be an endogenous retroviral element (intracisternal A-particle) [1].
Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene [1].
Comparative restriction mapping and DNA sequence analyses demonstrated that an intracisternal A-particle (IAP) element inserted approximately 2 kilobases 3' of an alpha 4-type myc gene to generate the alpha 25 gene copy [2].
In this study, we have identified and characterized a full-length rat intracisternal A-particle (IAP) element that has undergone an intronic transposition as the mechanism of inactivating the Tsc2 gene [3].
In this study, we analyzed the specific ER transport of the Gag polyprotein of the IAP element MIA14 [4].

Biological context of Genes, Intracisternal A-Particle

Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns [5].
Intracisternal A-particle (IAP) elements are present in multiple copies in the mouse and other rodent genomes [6].
A 784-bp fragment with 92% sequence homology to the intracisternal A-particle (IAP) element family was isolated from the latter cells [7].
The majority of type-II intracisternal A-particle (IAP) element clones isolated from a mouse genomic library also contained highly repetitive DNA sequences in addition to the moderately repetitive IAP elements [8].

Anatomical context of Genes, Intracisternal A-Particle

Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements [3].

Gene context of Genes, Intracisternal A-Particle

By sequence comparison of our clones with reported rodent IAP elements, we located the probable gag, pol and env gene regions [9].
Here we show that expression of the murine IAP element MIA14 yields three major translation products, corresponding to the Gag, Gag-PR, and Gag-PR-Pol polyproteins [10].

Analytical, diagnostic and therapeutic context of Genes, Intracisternal A-Particle

The ends of the inserted sequences were cloned by inverse PCR and revealed an intracisternal A-particle (IAP) element inserted near the 3' end of the intron [11].

References

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene. Hirsch, H.H., Nair, A.P., Moroni, C. J. Exp. Med. (1993) [Pubmed]
Acquisition of an intracisternal A-particle element by a translocated c-myc gene in a murine plasma cell tumor. Greenberg, R., Hawley, R., Marcu, K.B. Mol. Cell. Biol. (1985) [Pubmed]
Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements. Xiao, G.H., Jin, F., Yeung, R.S. Oncogene (1995) [Pubmed]
Transport of the intracisternal A-type particle Gag polyprotein to the endoplasmic reticulum is mediated by the signal recognition particle. Fehrmann, F., Jung, M., Zimmermann, R., Kräusslich, H.G. J. Virol. (2003) [Pubmed]
Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. Hawley, R.G., Shulman, M.J., Hozumi, N. Mol. Cell. Biol. (1984) [Pubmed]
Structural analysis of type II variants within the mouse intracisternal A-particle sequence family. Lueders, K.K., Mietz, J.A. Nucleic Acids Res. (1986) [Pubmed]
Differential expression of intracisternal A-particle transcripts in immunogenic versus tumorigenic S49 murine lymphoma cells. Braun, E., Rorman, E., Lueders, K.K., Bar-Sinai, A., Hochman, J. Virology (2000) [Pubmed]
Specific association between type-II intracisternal A-particle elements and other repetitive sequences in the mouse genome. Lueders, K.K. Gene (1987) [Pubmed]
Nucleotide sequence and molecular evolution of mouse retrovirus-like IAP elements. Aota, S., Gojobori, T., Shigesada, K., Ozeki, H., Ikemura, T. Gene (1987) [Pubmed]
Intracisternal A-type particles express their proteinase in a separate reading frame by translational frameshifting, similar to D-type retroviruses. Fehrmann, F., Welker, R., Kräusslich, H.G. Virology (1997) [Pubmed]
Intracisternal A-particle element transposition into the murine beta-glucuronidase gene correlates with loss of enzyme activity: a new model for beta-glucuronidase deficiency in the C3H mouse. Gwynn, B., Lueders, K., Sands, M.S., Birkenmeier, E.H. Mol. Cell. Biol. (1998) [Pubmed]

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