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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Embryonic Induction

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Disease relevance of Embryonic Induction


High impact information on Embryonic Induction

  • Interpretation of maps summarizing CAM distributions over a defined developmental epoch suggested a key role for both L-CAM and N-CAM in embryonic induction [2].
  • Is fundamental patterning of the head an early embryonic event, perhaps specified during primary embryonic induction or the consequence of neuroepithelial folding, brain growth, inductive interactions and/or spatially and temporally distributed extracellular matrix products [3]?
  • Since 1-octanol inhibited electrical communication between blastomeres at the 16- to 64-cell stage and also induced defects in formation of the archenteron, it is possible that gap junctions play a role in embryonic induction [4].
  • In mice, all of these genes have expression patterns indicative of involvement in embryonic induction (Chapman et al. (1996) Dev. Dyn., in press), and four (Tbx2-Tbx5) are represented as two cognate, linked gene pairs (Agulnik et al., (1996), Genetics, in press) [5].
  • E-cadherin, a calcium-dependent cell-cell adhesion molecule, is expressed in highly specific spatiotemporal patterns throughout metazoan development, notably at sites of embryonic induction [6].

Anatomical context of Embryonic Induction


Gene context of Embryonic Induction

  • The developmental expression of the integrated genes was examined by monitoring the embryonic induction of dopa decarboxylase enzyme activity (DDC) and by monitoring the developmental pattern of DDC activity from late third instar to eclosion [8].
  • The glp-1 gene is required for embryonic induction and continued germline proliferation; lin-12 is required for cells of equal developmental potential to adopt different fates [9].


  1. The stability of vitamin A-induced metaplasia of mouse vibrissa follicles in vitro. Hardy, M.H., Bellows, C.G. J. Invest. Dermatol. (1978) [Pubmed]
  2. Early epochal maps of two different cell adhesion molecules. Edelman, G.M., Gallin, W.J., Delouvée, A., Cunningham, B.A., Thiery, J.P. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  3. Patterning of connective tissues in the head: discussion report. Hall, B.K. Development (1988) [Pubmed]
  4. Functional gap junctions in the early sea urchin embryo are localized to the vegetal pole. Yazaki, I., Dale, B., Tosti, E. Dev. Biol. (1999) [Pubmed]
  5. Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity. Gibson-Brown, J.J., Agulnik, S.I., Chapman, D.L., Alexiou, M., Garvey, N., Silver, L.M., Papaioannou, V.E. Mech. Dev. (1996) [Pubmed]
  6. The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. Sorkin, B.C., Wang, M.Y., Dobeck, J.M., Albergo, K.L., Skobe, Z. J. Histochem. Cytochem. (2000) [Pubmed]
  7. Immunohistochemical localization of antioxidant enzymes during hamster kidney development. Oberley, T.D., Sempf, J.M., Oberley, L.W. Histochem. J. (1995) [Pubmed]
  8. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh, J.L., Gibbs, P.D., Timmons, P.M. Mol. Gen. Genet. (1985) [Pubmed]
  9. Genetic control of cellular interactions in Caenorhabditis elegans development. Kimble, J., Austin, J. Ciba Found. Symp. (1989) [Pubmed]
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