The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Paternal Age

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Paternal Age


High impact information on Paternal Age


Biological context of Paternal Age


Associations of Paternal Age with chemical compounds

  • There was a considerable variation for the indications advanced paternal age, amniocentesis for AFP or DNA, parental anxiety, a previous child with a congenital anomaly, abnormal maternal serum markers, and exposure to radiation/chemotherapy [8].

Gene context of Paternal Age

  • The authors' findings that sporadic cases were associated with advanced paternal age and that they all had mutations in FGFR2 are consistent with previous reports [9].
  • All molecularly characterized autosomal dominant HGP cases described so far result from de novo LMNA mutations, mostly originating on the paternal allele and are often linked with advanced paternal age [10].
  • Increased paternal age was associated with AD PSD but only in men [11].
  • Interestingly, a significant increase of mean paternal age (38.8 years, mean controls in France = 29.1 years, P less than 0.001) was found in this form of RP, a feature which is suggestive of new mutations [12].
  • RESULTS: Having 3 or more younger siblings, compared with none, produced an adjusted odds ratio (OR) for MS (with 95% confidence interval) of 0.80 (0.70-0.92) (adjusting for number of siblings, twins, maternal and paternal age, parental MS, sex, father's social class, county and year of birth) [13].

Analytical, diagnostic and therapeutic context of Paternal Age


  1. Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Wilkin, D.J., Szabo, J.K., Cameron, R., Henderson, S., Bellus, G.A., Mack, M.L., Kaitila, I., Loughlin, J., Munnich, A., Sykes, B., Bonaventure, J., Francomano, C.A. Am. J. Hum. Genet. (1998) [Pubmed]
  2. Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome. Tartaglia, M., Cordeddu, V., Chang, H., Shaw, A., Kalidas, K., Crosby, A., Patton, M.A., Sorcini, M., van der Burgt, I., Jeffery, S., Gelb, B.D. Am. J. Hum. Genet. (2004) [Pubmed]
  3. Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting. Farrer, L.A., Cupples, L.A., Kiely, D.K., Conneally, P.M., Myers, R.H. Am. J. Hum. Genet. (1992) [Pubmed]
  4. Predictors of IDDM recurrence risk in offspring of Danish IDDM patients. Danish IDDM Epidemiology and Genetics Group. Lorenzen, T., Pociot, F., Stilgren, L., Kristiansen, O.P., Johannesen, J., Olsen, P.B., Walmar, A., Larsen, A., Albrechtsen, N.C., Eskildsen, P.C., Andersen, O.O., Nerup, J. Diabetologia (1998) [Pubmed]
  5. Paternal age effect in fibrodysplasia ossificans progressiva. Rogers, J.G., Chase, G.A. J. Med. Genet. (1979) [Pubmed]
  6. A genetic study of torsion dystonia. Bundey, S., Harrison, M.J., Marsden, C.D. J. Med. Genet. (1975) [Pubmed]
  7. The relation of birth rank and parental age to the phenotype distributions of 14 genetic systems in an Australian population sample. Brackenridge, C.J., Case, J., Sheehy, A.J. Hum. Hered. (1976) [Pubmed]
  8. Variation in prenatal cytogenetic diagnosis: policies in 13 European countries, 1989-1991. EUROCAT Working Group. European Registration of Congenital Anomalies. Cornel, M.C. Prenat. Diagn. (1994) [Pubmed]
  9. FGFR2 mutations among Thai children with Crouzon and Apert syndromes. Shotelersuk, V., Mahatumarat, C., Ittiwut, C., Rojvachiranonda, N., Srivuthana, S., Wacharasindhu, S., Tongkobpetch, S. The Journal of craniofacial surgery. (2003) [Pubmed]
  10. Somatic and gonadal mosaicism in Hutchinson-Gilford progeria. Wuyts, W., Biervliet, M., Reyniers, E., D'Apice, M.R., Novelli, G., Storm, K. Am. J. Med. Genet. A (2005) [Pubmed]
  11. Epidemiology of presenile Alzheimer's disease in Scotland (1974-88) II. Exposures to possible risk factors. Whalley, L.J., Thomas, B.M., Starr, J.M. The British journal of psychiatry : the journal of mental science. (1995) [Pubmed]
  12. Clinical and genetic heterogeneity in retinitis pigmentosa. Kaplan, J., Bonneau, D., Frézal, J., Munnich, A., Dufier, J.L. Hum. Genet. (1990) [Pubmed]
  13. Parental age, family size, and risk of multiple sclerosis. Montgomery, S.M., Lambe, M., Olsson, T., Ekbom, A. Epidemiology (Cambridge, Mass.) (2004) [Pubmed]
  14. Paternal age and sporadic neurofibromatosis 1: a case-control study and consideration of the methodologic issues. Bunin, G.R., Needle, M., Riccardi, V.M. Genet. Epidemiol. (1997) [Pubmed]
WikiGenes - Universities