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MeSH Review

Hypothalamic Diseases

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Disease relevance of Hypothalamic Diseases


High impact information on Hypothalamic Diseases

  • The defect in ACTH secretion was apparently due to intrinsic pituitary rather than hypothalamic disease, because administration of lysine vasopressin did not stimulate ACTH release [6].
  • It was not possible to differentiate patients as having pituitary or hypothalamic disease based solely on the TRH test results [7].
  • This may be due to NTI per se, drugs administered for treatment of NTI, or associated pituitary or hypothalamic disease; the latter consideration may require evaluation of cortisol reserve, PRL, and/or gonadotropins [8].
  • If this were the case, the dynamics of PRL secretion in this instance would be similar to those in patients with stalk section, dopamine deficiency, or hypothalamic disease [9].
  • There was no systematic increase in ob-expression in obese children with hypothalamic disease compared to their healthy brothers and sisters [10].

Chemical compound and disease context of Hypothalamic Diseases


Gene context of Hypothalamic Diseases

  • OBJECTIVE: Insulin-induced hypoglycaemia is the standard method for assessment of the hypothalamo-pituitary-adrenal (HPA) axis of patients with pituitary or hypothalamic disease [13].
  • These are the transient DI syndromes due either to subclinical hypothalamic disease or to a disorder peculiar to pregnancy which is AVP-resistant but dDAVP-responsive; the latter analogue resists degradation by vasopressinase [14].

Analytical, diagnostic and therapeutic context of Hypothalamic Diseases


  1. Effects of human pancreatic tumour growth hormone releasing factor on growth hormone and somatomedin C levels in patients with idiopathic growth hormone deficiency. Borges, J.L., Blizzard, R.M., Gelato, M.C., Furlanetto, R., Rogol, A.D., Evans, W.S., Vance, M.L., Kaiser, D.L., MacLeod, R.M., Merriam, G.R., Loriaux, D.L., Spiess, J., Rivier, J., Vale, W., Thorner, M.O. Lancet (1983) [Pubmed]
  2. Repetitive infusion of gonadotropin-releasing hormone distinguishes hypothalamic from pituitary hypogonadism. Snyder, P.J., Rudenstein, R.S., Gardner, D.F., Rothman, J.G. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  3. An apparent cluster of congenital hypopituitarism in central Massachusetts: magnetic resonance imaging and hormonal studies. Brown, R.S., Bhatia, V., Hayes, E. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  4. Prolactin response to the dopamine antagonists sulpiride and domperidone. Further evidence for pituitary dopamine deficiency in hyperprolactinemic disorders of different etiology. Ferrari, C., Scarduelli, C., Rampini, P., Brambilla, G., Benco, R., Pistolesi, E., Paracchi, A., Mattei, A., Boghen, M., Crosignani, P.G. Gynecol. Obstet. Invest. (1983) [Pubmed]
  5. Hyperprolactinemia in sarcoidosis: incidence and utility in predicting hypothalamic involvement. Munt, P.W., Marshall, R.N., Underwood, L.E. Am. Rev. Respir. Dis. (1975) [Pubmed]
  6. Primary empty sella, hyperprolactinemia, and isolated ACTH deficiency after postpartum hemorrhage. Stacpoole, P.W., Kandell, T.W., Fisher, W.R. Am. J. Med. (1983) [Pubmed]
  7. Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children. Mehta, A., Hindmarsh, P.C., Stanhope, R.G., Brain, C.E., Preece, M.A., Dattani, M.T. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  8. Clinical review 86: Euthyroid sick syndrome: is it a misnomer? Chopra, I.J. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  9. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. Arafah, B.M., Nekl, K.E., Gold, R.S., Selman, W.R. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  10. Obese (ob) gene defects are rare in human obesity. Carlsson, B., Lindell, K., Gabrielsson, B., Karlsson, C., Bjarnason, R., Westphal, O., Karlsson, U., Sjöström, L., Carlsson, L.M. Obes. Res. (1997) [Pubmed]
  11. Endocrine evaluation of the infertile male. Snyder, P.J. Urol. Clin. North Am. (1978) [Pubmed]
  12. Chronic hypothermia and water intoxication associated with a neurodegenerative disease. Corbett, E.L., Sisodiya, S., Sarkar, D. Postgraduate medical journal. (1993) [Pubmed]
  13. A comparison between short ACTH and insulin stress tests for assessing hypothalamo-pituitary-adrenal function. Ammari, F., Issa, B.G., Millward, E., Scanion, M.F. Clin. Endocrinol. (Oxf) (1996) [Pubmed]
  14. Volume homeostasis and osmoregulation in human pregnancy. Davison, J.M., Lindheimer, M.D. Baillieres Clin. Endocrinol. Metab. (1989) [Pubmed]
  15. Growth hormone replacement inhibits renal and hepatic 11 beta-hydroxysteroid dehydrogenases in ACTH-deficient patients. Walker, B.R., Andrew, R., MacLeod, K.M., Padfield, P.L. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
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