Disease relevance of Vision Disorders

• A consecutive series of 58 diabetic eyes with fluorescein angiographically verified perifoveal edema and decreasing visual acuity and/or metamorphopsia was treated by orange dye laser photocoagulation in a perifoveal grid pattern [1].
• The diseases often result in encephalomyopathy, cardiomyopathy, vision disorders, dysacusis and metabolic disorders [2].

High impact information on Vision Disorders

• Zolpidem-induced macropsia in anorexic woman [3].
• Reversal of vision metamorphopsia (RVM) is a rare transient form of metamorphopsia described as an upside-down, 180 degrees rotation of the visual field in the coronal plane [4].
• After the perinatal period, boys had a 64% higher cumulative incidence of asthma, a 43% higher cumulative incidence of intellectual disability, a 22% higher incidence of mortality and a higher, but not statistically significant, incidence of epilepsy and vision disorders [5].
• Therefore, if visual acuity decreases or metamorphopsia develops in these patients, careful biomicroscopic examination and fluorescein/ICG angiography is advisable [6].
• Patients with Retinitis Pigmentosa (RP) show hemeralopia, restricted field of vision and reduced visual acuity, owing to the degeneration and proliferation of photoreceptors and a retinal pigment epithelium [7].

Gene context of Vision Disorders

• Mutations in GCAP1 that disrupt the Ca2+ regulation of Ret-GCs in vitro have been associated with severe human vision disorders [8].
• Bilateral symmetry of vision disorders in typical retinitis pigmentosa [9].

References